2013
DOI: 10.1016/j.mcn.2013.07.001
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Monocytes and macrophages as biomarkers for the diagnosis of megalencephalic leukoencephalopathy with subcortical cysts

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Cited by 18 publications
(27 citation statements)
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“…S3a,d). In macrophages from two MLC patients, each carrying a different MLC1 mutation (see Materials and methods), MLC1 immunoreactivity was almost undetectable in the plasma membrane, as previously reported (Petrini et al, 2013), and showed reduced colocalization with cytoplasmic organelle markers, particularly with Rab11 (Figs. S3b,c,e,f).…”
Section: Resultssupporting
confidence: 80%
“…S3a,d). In macrophages from two MLC patients, each carrying a different MLC1 mutation (see Materials and methods), MLC1 immunoreactivity was almost undetectable in the plasma membrane, as previously reported (Petrini et al, 2013), and showed reduced colocalization with cytoplasmic organelle markers, particularly with Rab11 (Figs. S3b,c,e,f).…”
Section: Resultssupporting
confidence: 80%
“…MLC1 expression is enriched in astrocytic processes contacting capillaries and meninges and in cerebellar Bergmann glia 15, 16, 17, 18. GlialCAM shows a similar expression pattern, and is also expressed in oligodendrocytes 17, 19.…”
Section: Introductionmentioning
confidence: 97%
“…14,15 Depletion of MLC1 in lymphoblasts and astrocytes reduces volumeregulated anion channel currents (VRAC) and slows the regulatory volume decrease after cell swelling. 14,15 Depletion of MLC1 in lymphoblasts and astrocytes reduces volumeregulated anion channel currents (VRAC) and slows the regulatory volume decrease after cell swelling.…”
mentioning
confidence: 99%
“…In humans, MLC1 is exclusively expressed in cells of astroglial lineage and leukocytes. 14,15 Depletion of MLC1 in lymphoblasts and astrocytes reduces volumeregulated anion channel currents (VRAC) and slows the regulatory volume decrease after cell swelling. 16 Despite emerging insights into the role of MLC1 in brain ionwater homeostasis, the pathomechanisms underlying MLC are still poorly understood.…”
mentioning
confidence: 99%