Monocyte-to-Lymphocyte Ratio Was an Independent Factor of the Severity of Spinal Tuberculosis

Chen, Liyi; Liu, Chong; Liang, Tuo; Ye, Zhen; Huang, Shengsheng; Chen, Jiarui; Sun, Xuhua; Yi, Ming; Jiang, Jie; Chen, Tianyou; Li, Hao; Chen, Wu‐Hua; Guo, Hao; Yao, Yuanlin; Liao, Shijie; Yu, Chaojie; Wu, Shaofeng; Fan, Binguang; Gan, Zhaoping; Zhan, Xinli

doi:10.1155/2022/7340330

Cited by 13 publications

(16 citation statements)

References 43 publications

(42 reference statements)

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“…11,41 Numerous inflammatory cytokines and chemokines, including interleukin1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-6 (IL-2), tumor necrosis factor-α (TNF-α), interferon-γ, and monocyte chemotactic protein-1 (MCP1), have been reported to be elevated in serum and ocular samples (vitreous and atrial fluid) of DR patients. 42 Hatori et al discovered that long-term use of nonsteroidal antiinflammatory drugs (NSAIDs) such as sulindac would be effective in preventing the progression of mild DR. 43 There is growing evidence that inflammation plays a significant role in the onset and progression of DR. 11 Numerous studieshave [14][15][16][17][18][19][20][21][22][23] demonstrated that NLR, PLR, and MLR are potential inflammatory biomarkers for tumors, cardiovascular disease, ankylosing spondylitis, rheumatoid arthritis, and inflammatory bowel disease. In addition, there is mounting evidence connecting them to the progression of DM and its complications.…”

Section: Discussionmentioning

confidence: 99%

“…20,21 Finally, it has been indicated that MLR is a prognostic factor in patients with cancer and tuberculosis. 22,23 Intriguingly, mounting evidence reveals that these inflammatory markers are also prognostic factors for DM and related complications. [24][25][26] As easily accessible and inexpensive inflammatory markers, the blood cellassociated inflammatory indices may hold promise as a new diagnostic tool for DR.…”

Section: Introductionmentioning

confidence: 99%

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The Platelet-to-Lymphocyte Ratio Predicts Diabetic Retinopathy in Type 2 Diabetes Mellitus

Zeng¹,

Chen²,

Qiu³

et al. 2022

DMSO

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Introduction As a severe and specific neurovascular complication of type 2 diabetes mellitus (T2DM), diabetic retinopathy (DR) remains the leading cause of vision loss and preventable blindness in adults aged 20 to 74. The pathogenesis of DR is not completely understood, however, studies indicate that chronic inflammation plays a significant role. Emerging evidence suggests that the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the monocyte-to-lymphocyte ratio (MLR) are novel potential inflammatory response markers. The purpose of this study was to investigate the relationships between the NLR, PLR, MLR, and DR. Patients and Methods 290 patients who had been diagnosed with T2DM participated in the study. Patients were categorized into three groups: 142 control subjects with T2DM, 124 subjects with nonproliferative diabetic retinopathy (NPDR), and 24 patients with proliferative diabetic retinopathy (PDR). Characteristics, laboratory data, as well as NLR, PLR and MLR levels of the study groups were compared. Results In patients with DR, the median NLR, PLR, and MLR were significantly higher than in patients without DR (p = 0.012, p < 0.001, and p = 0.043, respectively). In the post hoc analysis, there was no correlation between the severity of retinopathy and the increase in NLR or PLR. Multiple logistic regression revealed that the PLR was an independent risk factor for DR (odds ratio [OR]: 1.020, 95% confidence interval [CI]: 1.010–1.029 p = 0.026). Based on the receiver operating characteristic (ROC) curve, the cutoff value of PLR as an indicator for diagnosing DR was estimated to be 129.65, with a sensitivity and specificity of 53.4% and 76.1%, respectively, and an area under the curve of 0.668 (95% CI: 0.605–0.730, p < 0.001). Conclusion Our findings suggest that PLR may be an independent risk factor for evaluating DR in type 2 diabetes patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Platelet-to-Lymphocyte Ratio Predicts Diabetic Retinopathy in Type 2 Diabetes Mellitus

Zeng¹,

Chen²,

Qiu³

et al. 2022

DMSO

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“…They believed that MLR might predict active spinal tuberculosis and be associated with TS severity. 36 Liu et al also found that NEU, MONO, PLR, and other indicators can differentiate TS from PS. 37 In this study, we also analyzed the blood test results of patients with TS and PS.…”

Section: Discussionmentioning

confidence: 98%

A Predictive Clinical-Radiomics Nomogram for Differentiating Tuberculous Spondylitis from Pyogenic Spondylitis Using CT and Clinical Risk Factors

Wu¹,

Wei²,

Li³

et al. 2022

IDR

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Objective The study aimed to develop and validate a nomogram model with clinical risk factors and radiomic features for differentiating tuberculous spondylitis (TS) from pyogenic spondylitis (PS). Methods A total of 254 patients with TS (n = 141) or PS (n = 113) were randomly divided into training (n = 180) and validation (n = 74) groups. In addition, 43 patients (TS = 22 and PS = 21) were collected to construct a test cohort. t -test analysis, de-redundancy analysis, and minimum absolute shrinkage and selection operator (lasso) algorithm were utilized on the training set to obtain the optimal radiomics features from computed tomography (CT) for constructing the radiomics model and determine the radiomics score (Rad-score). Eight clinical risk predictors were identified to develop the clinical model. Combined with clinical risk predictors and Rad-scores, a nomogram model was constructed using multivariate logistic regression analysis. Results A total of 1781 features were extracted, and 12 optimal radiomic features were utilized to construct the radiomic model and determine the Rad-score. The combined clinical radiomics model revealed good discrimination performance in both the training cohort and the validation cohort (AUC = 0.891 and 0.830) and was superior to the clinical (AUC = 0.807 and 0.785) and radiomics (AUC = 0.796 and 0.811) models. The calibration curve and DCA also depicted that the nomogram had better clinical efficacy. The discriminative performance of the model is well validated in the test cohort (AUC=0.877). Conclusion The clinical radiomic nomogram could serve as a promising predictive tool for differentiating TS from PS, which could be helpful for clinical decision-making.

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“…At present, previous studies have reported the significant role of MLR in TB-related disease. Chen et al study showed that MLR was an independent factor in the diagnosis of spinal TB and was associated with the severity of spinal TB 22 . Choudhary et al study found that MLR was related to TB and declined with anti-TB treatment in HIV-infected children 23 .…”

Section: Discussionmentioning

confidence: 98%

Monocyte-to-lymphocyte ratio is significantly associated with positive QuantiFERON-TB Gold-In-Tube and adult survival: an observational study

Hua

Wang

2022

Sci Rep

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This study aimed to find significant factors associated with tuberculosis (TB) infection and disease development. The participants were from National Health and Nutrition Examination Survey (NHANES) and National Death Index (NDI). The tuberculosis infection was defined as a positive QuantiFERON-TB Gold-In-Tube (QFT-GIT). The Least Absolute Shrinkage and Selection Operator (LASSO) model was used to screen variables associated with QFT-GIT among 23 laboratory measures. Then the logistic regression analyses were performed to assess the independent factors, followed by a comprehensive nomogram model construction. Receiver operating characteristic (ROC) and Decision Curve (DCA) analyses were used to assess the performance of comprehensive model on QFT-GIT result and death risk. Of 5256 individuals included, 521 individuals had positive QFT-GIT. LASSO analysis indicated that 11 variables were associated with QFT-GIT result, and logistic regression analyses further found sodium and monocyte-to-lymphocyte ratio (MLR) were independent factors. After adjusting for potential confounders, the correlation of sodium and MLR with QFT-GIT result was still observed. The comprehensive model based on sodium, MLR, and important clinical characteristics can predict 0.8 probability of positive QFT-GIT and achieve more clinical net benefit. ROC analysis by training and validation sets showed the favorable prediction performance. Comprehensive model also presented favorable performance in evaluating the death risk of individuals with positive QFT-GIT. We also found MLR rather than sodium was independently related to the death risk. Both MLR itself and comprehensive model were all significantly related to the positive QFT-GIT and death risk, which might participate in the initiation and progression of tuberculosis infection.

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Monocyte-to-Lymphocyte Ratio Was an Independent Factor of the Severity of Spinal Tuberculosis

Cited by 13 publications

References 43 publications

The Platelet-to-Lymphocyte Ratio Predicts Diabetic Retinopathy in Type 2 Diabetes Mellitus

The Platelet-to-Lymphocyte Ratio Predicts Diabetic Retinopathy in Type 2 Diabetes Mellitus

A Predictive Clinical-Radiomics Nomogram for Differentiating Tuberculous Spondylitis from Pyogenic Spondylitis Using CT and Clinical Risk Factors

Monocyte-to-lymphocyte ratio is significantly associated with positive QuantiFERON-TB Gold-In-Tube and adult survival: an observational study

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