Monocyte to high-density lipoprotein cholesterol ratio is predictive of in-hospital and five-year mortality in ST-segment elevation myocardial infarction

Açi̇kgöz, Sadık Kadri; Açıkgöz, Eser; Şensoy, Barış; Topal, Salih; Aydoğdu, Sinan

doi:10.5603/cj.a2016.0026

Cited by 48 publications

(62 citation statements)

References 17 publications

(20 reference statements)

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“…42,43 Although the data on the MHR are limited, some studies revealed that MHR was also an important and valuable variable for cardiovascular events and MetS. 44,45 In another study, it was found that MetS can involve changes in blood parameters, and the lymphocyte to HDL-C ratio may be a useful marker of inflammation to assess the presence and severity of MetS. 14 In summary, in this study, two novel and independent hematological parameters were found.…”

Section: Discussionmentioning

confidence: 55%

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

Chen¹,

Chen²,

Tang³

et al. 2020

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Background: This study aimed to determine the optimal cutoff values and evaluate the associations of neutrophil to high-density lipoprotein cholesterol ratio (NHR) and lymphocyte to high-density lipoprotein cholesterol ratio (LHR) with metabolic syndrome (MetS), stratified by sex. Methods: A large-scale cross-sectional survey was conducted among 1401 adults from January to April 2018 in six communities in Wanzhai Town, Zhuhai City, on the southern coast of China. Receiver operating characteristics (ROC) analyses and logistic regression analysis were conducted to assess the optimal cutoff and value of NHR and LHR for predicting MetS. Results: Hematological parameters showed the correlation with the occurrence of MetS (red blood cells, hemoglobin, and white blood cells and subtypes). Binomial logistic regression analysis found that LHR (OR: 3.671; 95% CI: 2.385-5.651; p<0.001) and NHR (OR: 1.728; 95% CI: 1.353-2.207; p<0.001) can predict MetS in females, independent of confounding factors. Although LHR (OR: 1.571; 95% CI: 1.001-2.468; p=0.05) and NHR (OR: 1.163; 95% CI: 0.909-1.48; p<0.01) were independent risk factors for MetS in males after adjustment for age, current smoking, current alcohol use, physical activity, educational attainment, waist circumference, systolic pressure, diastolic pressure and hypersensitive C-reactive protein (hs-CRP), when further adjusted for fasting plasma glucose level, LHR and NHR, both lost their independence. ROC curves showed that LHR had the highest AUC for predicting MetS in females and NHR had the highest AUC in males. The cutoff points of LHR and NHR were 1.36 and 2.31 in females, and 1.96 and 3.38 in males. Conclusion: LHR and NHR may become valuable makers and have strong predictive power for predicting MetS, especially in females.

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Section: Discussionmentioning

confidence: 55%

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

Chen¹,

Chen²,

Tang³

et al. 2020

DMSO

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“…Previous studies have shown an association between high admission MHR with poorer cardiovascular outcomes among CKD patients [19], patients with atrial fibrillation [20], and ACS patients [22][23][24][25]. To the best of our knowledge, this is the first systematic review and meta-analysis demonstrating the impact of MHR with all cause mortality and major adverse cardiovascular events (MACE) among STEMI patients treated with primary PCI.…”

Section: Discussionmentioning

confidence: 81%

“…In this meta-analysis, it was showed that a high admission monocyte to HDL ratio (MHR) is associated with a higher risk of both in-hospital all cause mortality [RR 4.71, (95% CI 2.36 to 9.39)] and in-hospital MACEs [RR 1.90, (95% CI 1.44 to 2.50)]. Among STEMI patients treated with primary percutaneous coronary intervention, Karataş et al [23], Acikgoz et.al [24]., and Cicek et.al [25] demonstrated that high admission MHR values ere independently associated with higher rates of inhospital mortality and major adverse cardiovascular events such as ventricular arrhythmia (Ventricular Tachycardia or Fibrillation), re-infarction, cardiopulmonary resuscitation, and target vessel revascularization among patients with STEMI treated with primary PCI. In the study by Karatas et al [23], analysis showed MHR greater than 17.1 as a cutoff value for mortality and MHR greater than 20.4 as a cutoff value for MACE.…”

Section: Discussionmentioning

confidence: 99%

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Monocyte to High-Density Lipoprotein Ratio (MHR) as a predictor of mortality and Major Adverse Cardiovascular Events (MACE) among ST Elevation Myocardial Infarction (STEMI) patients undergoing primary percutaneous coronary intervention: a meta-analysis

et al. 2020

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Background: Monocyte to High Density Lipoprotein Ratio (MHR) is a new marker that has been associated with major adverse cardiovascular outcomes among STEMI patients. We sought to strengthen the association between MHR and mortality and major adverse cardiovascular events (MACEs) among STEMI patients who underwent primary percutaneous coronary intervention. Methods: Studies were included if they satisfied the following criteria:1) Observational Studies; 2) Adult patients with ST-elevation Myocardial Infarction (STEMI) who underwent primary percutaneous intervention (PCI); and 3) Reported data on mortality and major adverse cardiovascular events. Using MEDLINE, Clinical Key, Science Direct, Scopus, and Cochrane Central Register of Controlled Trials databases, a search for eligible studies was conducted until September 2017. Our primary outcome of interest was all-cause cardiovascular (CV) mortality. We also investigated the association between MHR and major adverse cardiovascular events (MACEs). Results: We identified 3 studies involving 2793 STEMI patients, showing that in STEMI patients who underwent primary PCI, a high admission MHR is associated with a significantly higher in-hospital mortality [RR 4.71, (95% CI 2.36 to 9.39, p < 0.00001] and in-hospital MACE [RR 1.90, (95% CI 1.44 to 2.50), p < 0.00001]. This significant association was not observed in long term mortality or MACE. Conclusion: A high admission MHR among STEMI patients who underwent primary PCI is associated with a higher in-hospital mortality and MACE. This novel marker can be used as an inexpensive and readily available tool for risk stratification.

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“…Monocytes interact with platelets and endothelial cells, which initiates pro-thrombotic and pro-inflammatory process (3). Monocytes differentiate into macrophages at the site of inflammation (4). Macrophages remove oxidized low-density lipoproteins (LDLs) and release inflammatory cytokines and metalloproteinases in the inflamed tissue (5).…”

Section: Introductionmentioning

confidence: 99%

Monocyte Count to HDL-Cholesterol Ratio May Be a Novel Cardiometabolic Marker in Patients With Functional Adrenal Tumors

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et al. 2019

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Monosit sayısının HDL-Kolesterole oranı (MHO), kardiyovasküler hastalığı olan hastalarda yüksek bulunmuş ve kardiyovasküler risk faktörleri için belirteç olduğu gösterilmiş. Fonksiyonel adrenal tümör ve fonksiyonel olmayan adrenal adenomlu hastalarda bile kardiyovasküler hastalık riski artmaktadır. Bu çalışmada ilk olarak, MHO'nun adrenal tümörlü hastalarda yüksek olup olmadığı ve kardiyometabolik risk faktörleri ile ilişkisi araştırıldı. GEREÇ VE YÖNTEM: Çalışmaya fonksiyonel adrenal tümürü olan 24 hasta (10 Cushing sendromu, 12 feokromositoma ve 2 primer hiperaldosteronizm), fonksiyonel olmayan adrenal adenomlu hasta (n=33) ve kontrol olgusu (n=50) alındı. Antropometrik inceleme, hormon ve biyokimyasal sonuçlar, lipid paneli, açlık kan şekeri (AKŞ), kan basıncı (KB), tam kan sayımı, C-reaktif protein (hs-CRP) ve karotis intima-media kalınlığı (KIMK) karşılaştırıldı. BULGULAR: Ortalama yaş (51.14±2.03'e karşın 54.01±9.37 yıl), cinsiyet dağılımı (kadın 66.7 %'a karşın 73.8 %) ve vücut kitle indeksi (31.12±3.38'a karşın 30.46±2.96 kg/m2) adrenal tümör ve kontrol grubu arasında benzerdi (sırasıyla, p>0.05). MHO değeri fonksiyonel tümör grubunda, fonksiyonel olmayan adenom ve kontrol grubuna göre, yüksek bulundu (13.79±3.14, 10,19±2,84 vs 10.08±1.82, sırasıyla, p<0.05). MHO değeri fonksiyonel olmayan adenom ve kontrol grubu arasında benzer bulundu (p>0,05). MHO değeri sistolik KB (r=0.480; p<0.001), diyastolik KB (r=0.452; p<0.001), AKŞ (r=0.333; p=0.001), hs-CRP (r=0.538, p=0.001) ve idrar normetanefrin düzeyi (r=0.302; p=0.043) ile pozitif korele idi. Kardiyovasküler hastalığı olan fonksiyonel adrenal tümörlü hastalarda, kardiyovasküler hastalığı olmayan fonksiyonel adrenal tümörlü hastalara göre, MHR değeri yüksek bulundu (14.69±2.67'e karşın 11.84±2.57, p<0.05). SONUÇ: Monosit sayısının HDL-Kolesterole oranı fonksiyonel adrenal tümörlü hastalarda yüksek bulunurken; fonksiyonel olmayan adenomlu hastalarda yüksek değildi. Monosit sayısının HDL-Kolesterole oranı kardiyometabolik risk faktörleri olan AKŞ, KB ve hs-CRP ile korele idi. Monosit sayısının HDL-Kolesterole oranı, fonksiyonel adrenal tümörlü hastalarda kardiyovasküler risk faktörleri için prediktif belirteç olabilir.

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Monocyte to high-density lipoprotein cholesterol ratio is predictive of in-hospital and five-year mortality in ST-segment elevation myocardial infarction

Cited by 48 publications

References 17 publications

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

<p>Comparison of the Value of Neutrophil to High-Density Lipoprotein Cholesterol Ratio and Lymphocyte to High-Density Lipoprotein Cholesterol Ratio for Predicting Metabolic Syndrome Among a Population in the Southern Coast of China</p>

Monocyte to High-Density Lipoprotein Ratio (MHR) as a predictor of mortality and Major Adverse Cardiovascular Events (MACE) among ST Elevation Myocardial Infarction (STEMI) patients undergoing primary percutaneous coronary intervention: a meta-analysis

Monocyte Count to HDL-Cholesterol Ratio May Be a Novel Cardiometabolic Marker in Patients With Functional Adrenal Tumors

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