Monocyte to high-density lipoprotein cholesterol ratio and serum uric acid in Chinese adults: a cross-sectional study

Li, Yuexi; Liu, Xiaoqin; Luo, Yuhan

doi:10.1186/s12902-022-00966-z

Cited by 9 publications

(6 citation statements)

References 48 publications

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“…These inflammatory cytokines could potentially enhance the activity of xanthine oxidase through the upregulation of its gene expression, resulting in an increase in UA production 33 . HDL-C has been confirmed as a protective factor against the elevation of serum uric acid in multiple studies, primarily due to its anti-inflammatory effects 18 , 34 , 35 . HDL inhibits endothelial inflammation and reduces the expression of key cellular adhesion molecules 36 .…”

Section: Discussionmentioning

confidence: 98%

Association of platelet to high-density lipoprotein cholesterol ratio with hyperuricemia

Yan,

Hu,

et al. 2024

Sci Rep

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The platelet/high-density lipoprotein ratio (PHR) has been identified as a significant indicator of inflammation and a hypercoagulable state, demonstrating a strong link with the severity of nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS). However, its correlation with hyperuricemia has not yet been documented. This study utilized a cross-sectional design, analyzing data collected from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2016 in the United States. The platelet/high-density lipoprotein ratio (PHR) was determined by dividing the number of platelets (PLT) by the level of high-density lipoprotein cholesterol (HDL-C). We employed multivariable logistic regression analyses, generalized additive models, and subgroup analyses to investigate the correlation between PHR and hyperuricemia. The study revealed a hyperuricemia prevalence of 18.56%. Analysis indicated a significant positive correlation between PHR and the risk of hyperuricemia (OR 1.11, 95% CI 1.08, 1.14). This correlation remained consistent across different subgroups including age, ethnicity, gender, and body mass index (BMI). Smooth curve fitting demonstrated a saturation effect between PHR and the risk of hyperuricemia. PHR is positively correlated with hyperuricemia and may serve as a novel biomarker for predicting the onset of this condition. Additionally, targeted interventions to improve PHR might help reduce the incidence of hyperuricemia.

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Section: Discussionmentioning

confidence: 98%

Association of platelet to high-density lipoprotein cholesterol ratio with hyperuricemia

Yan,

Hu,

et al. 2024

Sci Rep

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“…Monocytehigh-density lipoprotein ratio (MHL) is a recently described inflammatory marker for atherosclerotic disease and metabolic syndrome. A recent report highlighted the linear correlation of MHL with hyperuricemia irrespective of age, gender, BMI, blood pressure, and low-density lipoprotein (13).…”

Section: N Discussion and Conclusionmentioning

confidence: 99%

Acute severe gouty arthritis secondary to isotretinoin toxicity in a young male: a case report

Meena,

Kumar,

Bohra

2023

Reumatismo

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Acute gouty arthritis is a recognized complication of hyperuricemia and one of the most common forms of inflammatory arthritis in adults. Drug-induced hyperuricemia is increasingly prevalent in clinical practice. Diuretics, antitubercular medications, and immunosuppressants are the common drugs associated with hyperuricemia. Oral isotretinoin is the drug of choice for different forms of severe acne and is rarely associated with hyperuricemia. We present the case of a 30-year-old male with severe acne vulgaris who was prescribed isotretinoin and later presented with acute gout. The patient developed hyperuricemia and swelling of the right first metatarsophalangeal joint within two months of isotretinoin commencement. There was a second episode of similar joint swelling three months later, parallel to the isotretinoin rechallenge. The dose of isotretinoin was reduced with the addition of febuxostat. The patient did not develop further episodes and remained symptom-free without urate-lowering therapy.

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“…Elevate TG can lead to a high level of free fatty acid production and utilization, which could accelerate the decomposition of adenosine triphosphate, and this process increased the production of uric acid and causes its abnormal rise in blood [38]. Second, many studies have confrmed that HDL-C is a protective factor against serum uric acid elevation in general [39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Higher Atherogenic Index of Plasma Is Associated with Hyperuricemia: A National Longitudinal Study

Xu,

Ma,

Wang

et al. 2024

International Journal of Endocrinology

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Background. The association between atherogenic index of plasma (AIP) and hyperuricemia remains indistinct. This study was aimed to examine the relationship between AIP and hyperuricemia among the middle-aged and the elderly Chinese population. Methods. Datasets were retrieved from the China Health and Retirement Longitudinal Study (CHARLS) survey conducted in 2011 and 2015. 13,021 participants in the CHARLS in 2011 and 7,017 participants involved both in 2011 and 2015 were included, respectively. The measurement of AIP and hyperuricemia was based on the test of fasting blood. Association between AIP and hyperuricemia was assessed by logistic regression, and the nonlinear association was examined by restricted cubic splines (RCS). The cutoff point of AIP was calculated using receiver operator curve (ROC). 1 : 1 propensity score matching (PSM) was adopted to further explore the relationship between AIP and hyperuricemia. Results. In the section of a cross-sectional study, a positive association between AIP and hyperuricemia was found. The odds ratios (ORs) of hyperuricemia were 1.00 (reference), 1.52 (1.10–2.10), 1.80 (1.31–2.47), and 3.81 (2.84–5.11). Nonlinear association was not detected using RCS analysis. There were 664 hyperuricemia cases during the four years follow-up. The hyperuricemia prevalence was 9.5%. In the fully adjusted longitudinal analysis, the ORs for hyperuricemia across the quartiles of AIP were 1.00 (reference), 1.00 (0.74–1.37), 1.59 (1.20–2.11), and 2.55 (1.94–3.35), respectively. In the longitudinal analysis after PSM, the OR of hyperuricemia were 1.91 (1.45, 2.51) and 1.92 (1.45, 2.54) in the univariate and multivariate model, respectively. Conclusion. AIP can predict the prevalence of hyperuricemia in the Chinese middle-aged and elderly population.

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Monocyte to high-density lipoprotein cholesterol ratio and serum uric acid in Chinese adults: a cross-sectional study

Cited by 9 publications

References 48 publications

Association of platelet to high-density lipoprotein cholesterol ratio with hyperuricemia

Association of platelet to high-density lipoprotein cholesterol ratio with hyperuricemia

Acute severe gouty arthritis secondary to isotretinoin toxicity in a young male: a case report

Higher Atherogenic Index of Plasma Is Associated with Hyperuricemia: A National Longitudinal Study

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