Monocyte subsets involved in the development of systemic lupus erythematosus and rheumatoid arthritis

Hirose, Sachiko; Lin, Qingshun; Ohtsuji, Mareki; Nishimura, Hiroyuki; Verbeek, J. Sjef

doi:10.1093/intimm/dxz036

Cited by 67 publications

(52 citation statements)

References 116 publications

(128 reference statements)

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“…Abnormalities of monocyte subsets have been reported in many studies and was associated with a wide range of diseases and related to disease prognosis (Hirose et al, 2019;Nabatanzi et al, 2019). Our study found that syphilis patients demonstrate changes in monocyte subpopulations, of which intermediate monocytes were significantly increased.…”

Section: Discussionsupporting

confidence: 64%

Treponemapallidum Dysregulates Monocytes and Promotes the Expression of IL-1β and Migration in Monocytes Through the mTOR Signaling Pathway

Liu

Jiang

et al. 2020

Front. Cell. Infect. Microbiol.

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Section: Discussionsupporting

confidence: 64%

Treponemapallidum Dysregulates Monocytes and Promotes the Expression of IL-1β and Migration in Monocytes Through the mTOR Signaling Pathway

Liu

Jiang

et al. 2020

Front. Cell. Infect. Microbiol.

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“…There was also a trend toward an increased absolute number of classical monocytes in flare compared with remission (P = 0.08), but there was no change in the absolute number of nonclassical monocytes between flare and remission ( Figure 4, E and F). Classical monocytes tend to be more proinflammatory in function, although both monocyte subsets have been shown to promote inflammation and contribute to pathogenesis in autoimmune diseases such as SLE and rheumatoid arthritis (20).…”

Section: Resultsmentioning

confidence: 99%

Type I IFN response associated with mTOR activation in the TAFRO subtype of idiopathic multicentric Castleman disease

Pai¹,

Japp²,

Gonzalez³

et al. 2020

JCI Insight

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“…Monocytes were the prominent differentially expressed cells. These are important components of the innate immune system; they have an antigen presentation capacity and produce several inflammatory cytokines in SLE [19]. Monocytes accounted for approximately 4% of blood leukocytes in healthy mice and over 50% in lupus-prone mice [20].…”

Section: Discussionmentioning

confidence: 99%

Immune cell infiltration characteristics and related core genes in lupus nephritis: results from bioinformatic analysis

Cao

Tang

2019

Preprint

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Background Lupus nephritis (LN) is a common complication of systemic lupus erythematosus that presents a high risk of end-stage renal disease. In the present study, we used CIBERSORT and gene set enrichment analysis (GSEA) of gene expression profiles to identify immune cell infiltration characteristics and related core genes in LN. Results Datasets from the Gene Expression Omnibus, GSE32591 and GSE113342, were downloaded for further analysis. The GSE32591 dataset, which included 32 LN glomerular biopsy tissues and 14 glomerular tissues from living donors, was analyzed by CIBERSORT. Different immune cell types in LN were analyzed by the Limma software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis based on GSEA were performed by clusterProfiler software. Lists of core genes were derived from Spearman correlation between the most significant GO term and differentially expressed immune cell gene from CIBERSORT. GSE113342 was employed to validate the association between selected core genes and clinical manifestation. Five types of immune cells revealed important associations with LN, and monocytes emerged as having the most prominent differences. GO and KEGG analyses indicated that immune response pathways are significantly enriched in LN. The Spearman correlation indicated that 15 genes, including FCER1G, CLEC7A, MARCO, CLEC7A, PSMB9, and PSMB8 , were closely related to clinical features. Conclusions This study is the first to identify immune cell infiltration with microarray data of glomeruli in LN by using CIBERSORT analysis and provides novel evidence and clues for further research of the molecular mechanisms of LN.

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Monocyte subsets involved in the development of systemic lupus erythematosus and rheumatoid arthritis

Abstract: The diverse roles of monocytes in SLE and RA

Cited by 67 publications

References 116 publications

Treponemapallidum Dysregulates Monocytes and Promotes the Expression of IL-1β and Migration in Monocytes Through the mTOR Signaling Pathway

Treponemapallidum Dysregulates Monocytes and Promotes the Expression of IL-1β and Migration in Monocytes Through the mTOR Signaling Pathway

Type I IFN response associated with mTOR activation in the TAFRO subtype of idiopathic multicentric Castleman disease

Immune cell infiltration characteristics and related core genes in lupus nephritis: results from bioinformatic analysis

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