Monocyte regulation by gut microbial signals

Kolypetri, Panayota; Weiner, Howard L.

doi:10.1016/j.tim.2023.05.006

Cited by 4 publications

(2 citation statements)

References 118 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, the products of gut microbiome (LPS, flagellin, etc.) in the blood can regulate the functions of trafficking monocytes [ 58 ]. In NDs, transplantation of the faecal microbiome from healthy donors has been shown to ameliorate microglial reactivity and functional impairments in both AD and PD mice, and decrease the levels of circulating blood inflammatory monocytes in AD mice [ 59 ].…”

Section: Pathways By Which the Gut Microbiome Communicates With The B...mentioning

confidence: 99%

Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside

Ma,

Li,

et al. 2024

Transl Neurodegener

View full text Add to dashboard Cite

The aetiologies and origins of neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD), are complex and multifaceted. A growing body of evidence suggests that the gut microbiome plays crucial roles in the development and progression of neurodegenerative diseases. Clinicians have come to realize that therapeutics targeting the gut microbiome have the potential to halt the progression of neurodegenerative diseases. This narrative review examines the alterations in the gut microbiome in AD, PD, ALS and HD, highlighting the close relationship between the gut microbiome and the brain in neurodegenerative diseases. Processes that mediate the gut microbiome–brain communication in neurodegenerative diseases, including the immunological, vagus nerve and circulatory pathways, are evaluated. Furthermore, we summarize potential therapeutics for neurodegenerative diseases that modify the gut microbiome and its metabolites, including diets, probiotics and prebiotics, microbial metabolites, antibacterials and faecal microbiome transplantation. Finally, current challenges and future directions are discussed.

show abstract

Section: Pathways By Which the Gut Microbiome Communicates With The B...mentioning

confidence: 99%

Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside

Ma,

Li,

et al. 2024

Transl Neurodegener

View full text Add to dashboard Cite

show abstract

“…The apoptosis rate of Ly6C High monocytes from NOD1 − / − mice is higher compared to wild-type monocytes. 74 …”

Section: Gut Microbiota and Hematopoiesismentioning

confidence: 99%

Ecological insights into hematopoiesis regulation: unraveling the influence of gut microbiota

Zheng,

Wei,

2024

Gut Microbes

View full text Add to dashboard Cite

The gut microbiota constitutes a vast ecological system within the human body, forming a mutually interdependent entity with the host. In recent years, advancements in molecular biology technologies have provided a clearer understanding of the role of the gut microbiota. They not only influence the local immune status and metabolic functions of the host’s intestinal tract but also impact the functional transformation of hematopoietic stem cells (HSCs) through the gut-blood axis. In this review, we will discuss the role of the gut microbiota in influencing hematopoiesis. We analyze the interactions between HSCs and other cellular components, with a particular emphasis on the direct functional regulation of HSCs by the gut microbiota and their indirect influence through cellular components in the bone marrow microenvironment. Additionally, we propose potential control targets for signaling pathways triggered by the gut microbiota to regulate hematopoietic function, filling crucial knowledge gaps in the development of this research field.

show abstract