Monocyte-platelet aggregates and platelet micro-particles in patients with post-hepatitic liver cirrhosis

Sayed, Douaa; Amin, Nabila F.; Galal, Ghada Moustafa

doi:10.1016/j.thromres.2009.12.002

Cited by 37 publications

(33 citation statements)

References 49 publications

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“…More recent flow cytometry analysis of platelet activation, as well as platelet-monocyte aggregates, is consistent with hyperactivation of platelets in cirrhosis [134,135].…”

Section: Thrombocytopathy In Liver Cirrhosismentioning

confidence: 63%

Patients with liver cirrhosis suffer from primary haemostatic defects? Fact or fiction?

Violi

Basili

Raparelli

et al. 2011

Journal of Hepatology

156

162

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Patients with cirrhosis can have abnormalities in laboratory tests reflecting changes in primary haemostasis, including bleeding time, platelet function tests, markers of platelet activation, and platelet count. Such changes have been considered particularly relevant in the bleeding complications that occur in cirrhosis. However, several studies have shown that routine diagnostic tests, such as platelet count, bleeding time, PFA-100, thromboelastography are not clinically useful to stratify bleeding risk in patients with cirrhosis. Moreover, treatments used to increase platelet count or to modulate platelet function could potentially do harm. Consequently the optimal management of bleeding complications is still a matter of discussion. Moreover, in the last two decades there has been an increased recognition that not only bleeding but also thrombosis complicates the clinical course of cirrhosis. Thus, we performed a literature search looking at publications studying both qualitative and quantitative aspects of platelet function to verify which primary haemostasis defects occur in cirrhosis. In addition, we evaluated the contribution of qualitative and quantitative aspects of platelet function to the clinical outcome in cirrhosis and their therapeutic management according to the data available in the literature. From the detailed analysis of the literature, it appears clear that primary haemostasis may not be defective in cirrhosis, and a low platelet count should not necessarily be considered as an automatic index of an increased risk of bleeding. Conversely, caution should be observed in patients with severe thrombocytopenia where its correction is advised if bleeding occurs and before invasive diagnostic and therapeutic procedures.

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“…More recent flow cytometry analysis of platelet activation, as well as platelet-monocyte aggregates, is consistent with hyperactivation of platelets in cirrhosis [134,135].…”

Section: Thrombocytopathy In Liver Cirrhosismentioning

confidence: 63%

Patients with liver cirrhosis suffer from primary haemostatic defects? Fact or fiction?

Violi

Basili

Raparelli

et al. 2011

Journal of Hepatology

156

162

View full text Add to dashboard Cite

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“…Portal hypertension, which causes thrombocytopenia, may entail a hemorrhagic diathesis. In addition, porto-systemic shunting and gut barrier disruption facilitate endotoxaemia and contribute to the hemorragic diathesis [60].…”

Section: Factors Tipping the Hemostatic Balance In Cirrhosismentioning

confidence: 99%

Hemostatic balance in patients with liver cirrhosis: Report of a consensus conference

Andriulli

Tripodi

Angeli

et al. 2016

Digestive and Liver Disease

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a b s t r a c tPatients with cirrhosis present with hemostatic alterations secondary to reduced availability of procoagulant and anti-coagulant factors. The net effect of these changes is a rebalanced hemostatic system. The Italian Association of the Study of the Liver (AISF) and the Italian Society of Internal Medicine (SIMI) promoted a consensus conference on the hemostatic balance in patients with cirrhosis. The consensus process started with the review of the literature by a scientific board of experts and ended with a formal consensus meeting in Rome in December 2014. The statements were graded according to quality of evidence and strength of recommendations, and approved by an independent jury. The statements presented here highlight strengths and weaknesses of current laboratory tests to assess bleeding and thrombotic risk in cirrhotic patients, the pathophysiology of hemostatic perturbations in this condition, and outline the optimal management of bleeding and thrombosis in patients with liver cirrhosis.

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“…Moreover, liver cirrhosis is associated with thrombocytopenia, which appears to be multifactorial following a reduced production, a splenic sequestration, or an increased destruction of platelets . Two early publications reported an inverse correlation between platelets and PEV counts, but recent publications did not . This discrepancy can be explained by the methods used to characterize PEVs.…”

Section: Chronic Liver Diseasesmentioning

confidence: 89%

Platelets and Platelet‐Derived Extracellular Vesicles in Liver Physiology and Disease

et al. 2019

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Beyond their role in hemostasis, platelets are proposed as key mediators of several physiological and pathophysiological processes of the liver, such as liver regeneration, toxic or viral acute liver injury, liver fibrosis, and carcinogenesis. The effects of platelets on the liver involve interactions with sinusoidal endothelial cells and the release of platelet‐contained molecules following platelet activation. Platelets are the major source of circulating extracellular vesicles, which are suggested to play key roles in platelet interactions with endothelial cells in several clinical disorders. In the present review, we discuss the implications of platelet‐derived extracellular vesicles in physiological and pathophysiological processes of the liver.

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Monocyte-platelet aggregates and platelet micro-particles in patients with post-hepatitic liver cirrhosis

Cited by 37 publications

References 49 publications

Patients with liver cirrhosis suffer from primary haemostatic defects? Fact or fiction?

Patients with liver cirrhosis suffer from primary haemostatic defects? Fact or fiction?

Hemostatic balance in patients with liver cirrhosis: Report of a consensus conference

Platelets and Platelet‐Derived Extracellular Vesicles in Liver Physiology and Disease

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