Monocyte-Plasmablast Crosstalk during Dengue

Green, Angela M.; Harris, Eva

doi:10.1016/j.chom.2014.06.011

Cited by 9 publications

(12 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…mCD169 seems to be a general biomarker of acute viral infections since it has been found in patients with HIV (16, 18,19), EBV (20), RSV (21), CMV (22), Dengue (23,24), Zika (25), noroviruses (26), Lassa and Marburg (27). Here, high levels of mCD169 have been observed for the first time for Flu A virus.…”

Section: Discussionmentioning

confidence: 66%

“…Ability of nCD64 to discriminate between bacterial and non-bacterial infections has been largely demonstrated for years (17), whereas mCD169 increase after infection by viruses has only been described recently. mCD169 seems to be a general biomarker of acute viral infections since it has been found in patients with HIV (16,18,19), EBV (20), RSV (21), CMV (22), Dengue (23,24), Zika (25), noroviruses (26), Lassa and Marburg (27). Here, high levels of mCD169 have been observed for the first time for Flu A virus.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

CD64 and CD169 could help differentiate bacterial from viral infections in Emergency Department

Bourgoin

Soliveres²,

Barbaresi³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The identification of a bacterial, viral or even non-infectious cause is essential in the management of febrile syndrome in the emergency department (ED) setting, especially in epidemic contexts such as flu or CoVID-19. Objectives: The aim of this study was to assess discriminative performances of two biomarkers, CD64 on neutrophils (nCD64) and CD169 on monocytes (mCD169), using a new flow cytometry procedure, in patients presenting with fever to the ED. Human leucocyte antigen-DR on monocytes (mHLA-DR), HLA-ABC ratio (rHLA-ABC), and CD64 on monocytes (mCD64) were also assessed. Methods: 85 adult patients presenting with potential infection were included during the 2019 flu season in the ED of La Timone Hospital. They were divided into four diagnostic outcomes according to their clinical records: no-infection, bacterial infection, viral infection and co-infection. Results: mCD169 was elevated in patients suffering from Flu A virus or Respiratory Syncytial Virus, while nCD64 was mainly found elevated in subjects with Streptococcus pneumoniae. In total, 38 (45%) patients were diagnosed with bacterial infections, 11 (13%) with viral infections and 29 (34%) with co-infections. nCD64 and mCD169 showed 90% and 80% sensitivity, and 78% and 91% specificity, respectively, for identifying patients with bacterial or viral infections. Other biomarkers had lower discriminative performances. Conclusions: nCD64 and mCD169 have potential for accurately distinguishing bacterial and acute viral infections. Combined in an easy and rapid flow cytometry procedure, they constitute a potential improvement for infection management in the ED setting, and could even help for the triage of patients during emerging epidemics.

show abstract

Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

CD64 and CD169 could help differentiate bacterial from viral infections in Emergency Department

Bourgoin

Soliveres²,

Barbaresi³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…14 Ability of nCD64 to discriminate between bacterial and nonbacterial infections has been largely demonstrated for years, 17 whereas mCD169 increase after infection by viruses has only been described recently. mCD169 seems to be a general biomarker of acute viral infections since it has been found in patients with HIV, 16,18,19 EBV, 20 RSV, 21 CMV, 22 dengue, 23,24 Zika, 25 noroviruses, 26 Lassa, and Marburg. 27 Here, high levels of mCD169 have been observed for the first time for Flu A virus.…”

Section: Discussionmentioning

confidence: 99%

CD169 and CD64 could help differentiate bacterial from CoVID‐19 or other viral infections in the Emergency Department

et al. 2021

View full text Add to dashboard Cite

The identification of a bacterial, viral, or even noninfectious cause is essential in the management of febrile syndrome in the emergency department (ED), especially in epidemic contexts such as flu or CoVID‐19. The aim was to assess discriminative performances of two biomarkers, CD64 on neutrophils (nCD64) and CD169 on monocytes (mCD169), using a new flow cytometry procedure, in patients presenting with fever to the ED during epidemics. Eighty five adult patients presenting with potential infection were included during the 2019 flu season in the ED of La Timone Hospital. They were divided into four diagnostic outcomes according to their clinical records: no‐infection, bacterial infection, viral infection and co‐infection. Seventy six patients with confirmed SARS‐CoV‐2 infection were also compared to 48 healthy volunteers. For the first cohort, 38 (45%) patients were diagnosed with bacterial infections, 11 (13%) with viral infections and 29 (34%) with co‐infections. mCD169 was elevated in patients with viral infections, with a majority of Flu A virus or Respiratory Syncytial Virus, while nCD64 was elevated in subjects with bacterial infections, with a majority of Streptococcus pneumoniae and Escherichia coli . nCD64 and mCD169 showed 90% and 80% sensitivity, and 78% and 91% specificity, respectively, for identifying patients with bacterial or viral infections. When studied in a second cohort, mCD169 was elevated in 95% of patients with SARS‐CoV‐2 infections and remained at normal level in 100% of healthy volunteers. nCD64 and mCD169 have potential for accurately distinguishing bacterial and acute viral infections. Combined in an easy and rapid flow cytometry procedure, they constitute a potential improvement for infection management in the ED, and could even help for triage of patients during emerging epidemics.

show abstract

“…Likewise, the AZD1222-induced changes among peripheral immune cell proportions are reminiscent of viral infections. For instance, short-term enrichments of pro-inflammatory monocytes have been observed in patients infected with Dengue or human immunodeficiency virus, respectively 25,26 . Both, the enrichment of CD4 + effector memory T cells re-expressing RA (TEMRA) and terminally differentiated cytotoxic CD8 + T cells have been associated with human cytomegalovirus [27][28][29] .…”

Section: Figure Discussionmentioning

confidence: 99%

Single-Dose SARS-CoV-2 Vaccination With BNT162b2 and AZD1222 Induce Disparate Th1 Responses and IgA Production

Müller

Volzke

Subin

et al. 2021

Preprint

View full text Add to dashboard Cite

While vaccination programs against SARS-CoV-2 are globally ongoing, disparate strategies for the deployment of spike antigen show varying effectiveness. In order to explore this phenomenon, we sought to compare the early immune responses against AZD1222 and BNT162b2. SARS-CoV-2 seronegative participants received a single dose of either vaccine and were analyzed for immune cell, effector T cell and antibody dynamics. AZD1222 induced transient leukopenia and major changes among innate and adaptive subpopulations. Both vaccines induced spike protein specific effector T cells which were dominated by Th1 responses following AZD1222 vaccination. A significant reduction of anti-inflammatory T cells upon re-stimulation was also restricted to AZD1222 vaccinees. While IgM and IgG were the dominant isotypes elicited by AZD1222, BNT162b2 led to a significant production of IgG and IgA. Our results suggest that the strategy for spike antigen delivery impacts on how and to what extent immune priming against the main SARS-CoV-2 antigen proceeds.

show abstract

Monocyte-Plasmablast Crosstalk during Dengue

Cited by 9 publications

References 10 publications

CD64 and CD169 could help differentiate bacterial from viral infections in Emergency Department

CD64 and CD169 could help differentiate bacterial from viral infections in Emergency Department

CD169 and CD64 could help differentiate bacterial from CoVID‐19 or other viral infections in the Emergency Department

Single-Dose SARS-CoV-2 Vaccination With BNT162b2 and AZD1222 Induce Disparate Th1 Responses and IgA Production

Contact Info

Product

Resources

About