Monocyte infiltration is an independent positive prognostic biomarker in vulvar squamous cell carcinoma
Ziena Abdulrahman,
Kim E. Kortekaas,
Marij J. P. Welters
et al.
Abstract:Background
Vulvar squamous cell carcinoma (VSCC) arises after an HPV infection or the mutation of p53 or other driver genes and is treated by mutilating surgery and/or (chemo) radiation, with limited success and high morbidity. In-depth information on the immunological make up of VSCC is pivotal to assess whether immunotherapy may form an alternative treatment.
Methods
A total of 104 patient samples, comprising healthy vulva (n = 27) and VSCC (n = … Show more
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