Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients

Bolayir, Aslı; Gökçe, Şeyda Figül; Çiğdem, Burhanettin; Bolayır, Hasan Ata; Yıldız, Özlem; Bolayır, Ertuğrul; Topaktaş, Suat

doi:10.1016/j.pjnns.2017.08.011

Cited by 80 publications

(80 citation statements)

References 25 publications

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“…By the way inhibiting the inflammatory response, infarct size begins to be smaller (21,22). Bolayir et al showed that higher monocyte counts' prognosis in acute CVD was worse than lower monocyte counts (6). In our study we also found that higher monocyte levels were related with poor prognosis too.…”

Section: Discussionsupporting

confidence: 70%

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Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?

Tekin

Avcı

Nar

et al. 2020

J Basic Clin Health Sci

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Background: We investigated the association of monocyte to high-density lipoprotein cholesterol (HDL) ratio (MHR), neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ratio (LMR) with prognostic value and infarct types in patients with acute ischemic cerebrovascular disease (CVD). Matherial and Methods: The study was carried out retrospectively in 223 patients, but after the exclusion criterion, 150 patients with acute ischemic CVD were included to the study. The complete blood count and lipid profile were examined at the admission of the patients. For initial neurologic status, National Institutes of Health Stroke Scale (NIHSS) score and for following-up, modified Rankin Scale (mRS) score were evaluated. After the etiological investigations and neuroimaging, infarct types were defined. Results: We found that as the NIHSS score increased, LMR values decreased and NLR values increased statistically (p=0.02, p=0.013). Additionally, statistical significant differences were determined between MHR values and mRS scores (p=0.045). According to the results of regression analysis, it was observed that the increase of MHR was statistically significant on the MRS of people with cardioembolic infarction (p=0.004, StB=0.383). Conclusion: Our study provides, LMR and NLR values are related with the initial neurologic state, and they would be prognostic markers for the neurological deficit of acute cerebrovascular disease. MHR can be a follow-up marker for CVD and also a predictable marker for cardioembolic infarct type.

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Section: Discussionsupporting

confidence: 70%

“…There is one study available in the literature that examines the MHR value and mortality in acute ischemic cerebrovascular disease. In this study, high MHR values have been shown to be independent predictors of mortality after acute CVD (6). However, the relationship between infarct subtypes and MHR has not been studied yet.…”

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confidence: 71%

Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?

Tekin

Avcı

Nar

et al. 2020

J Basic Clin Health Sci

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“…It has been shown that high monocyte count and low HDL-C levels may be relevant to inflammation (Acikgoz et al, 2017;Bolayir et al, 2017;Kundi et al, 2015;You et al, 2017;Yucetas, Kadihasanoglu, Karabay, Erkan, & Ozbek, 2017) and oxidative stress (Acikgoz et al, 2017), and it has been reported that the MHR is a new prognostic marker in several CVDs (Karataş et al, 2016;M. S. Cetin et al, 2016;You et al, 2017).…”

Section: Mhr As a Prognostic Markermentioning

confidence: 99%

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

Ganjali

Gotto

Ruscica

et al. 2018

Journal Cellular Physiology

199

188

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Inflammation and lipid accumulation are two basic hallmarks of atherosclerosis as a chronic disease. Inflammation not only is a local response but can also be considered as a systemic process followed by an elevation of inflammatory mediators. Monocytes are a major source of proinflammatory species during atherogenesis. In atherosclerosis, modified low-density lipoproteins (LDLs) are removed by macrophages; these are recruited in the vessel wall, inducing the release of inflammatory cytokines in inflamed tissue. Hence, inflammatory cholesterol ester-loaded plaque is generated. High-density lipoprotein-cholesterol (HDL-C) exhibits antiatherosclerotic effects by neutralizing the proinflammatory and pro-oxidant effects of monocytes via inhibiting the migration of macrophages and LDL oxidation in addition to the efflux of cholesterol from these cells. Furthermore, HDL plays a role in suppressing the activation of monocytes and proliferation-differentiation of monocyte progenitor cells. Thus, accumulation of monocytes and reduction of HDL-C may participate in atherosclerosis and cardiovascular diseases (CVD). Given that the relationship between the high number of monocytes and low HDL-C levels has been reported in inflammatory disorders, this review focused on understanding whether the monocyte-to-HDL ratio could be a convenient marker to predict atherosclerosis development and progression, hallmarks of CV events, instead of the individual monocyte count or HDL-C level.

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“…As MHR is an inexpensive and readily available parameter, it has become more widely used in recent years, and has been related to several clinical conditions (13)(14)(15)(16). The relationship between OSAS and MHR was first investigated by Atan et al in 2007, and it was determined that MHR could be a predictive marker in OSAS diagnosis (17).…”

Section: Discussionmentioning

confidence: 99%

The Monocyte/HDL Cholesterol Ratio in Obstructive Sleep Apnea Syndrome

Acat¹,

Yazici²

2018

meandros

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Objective: Obstructive sleep apnea syndrome (OSAS) is the most common condition among sleep-related respiratory disorders. The etiology is not clear. However, systemical and local inflammation in the respiratory tract of the patients has been acknowledged. Monocytes and macrophages play the critical role in the inflammation process. These cells participate in the release of the proinflammatory cytokines in inflammation sites. High-density lipoprotein (HDL) cholesterol is a molecule with an anti-inflammatory effect. Monocyte/HDL cholesterol ratio (MHR) is an inflammation marker being used recently. In our study, we aimed to compare inflammation marker levels between patients diagnosed with OSAS with subsequent polysomnography and the non OSAS group, determine the relationship between the severity of OSAS and MHR and, investigate the utility of the MHR for diagnosing OSAS. Materials and Methods: The data from the patients' files who had polysomnography due to OSAS symptoms in our unit between July 2017 and December 2017 have been retrospectively analyzed, and polysomnography results were recorded. Demographic data and the results of biochemistry and complete blood count (CBC) panels of patients with OSAS and who were not also were recorded. Results: Out of 147 patients who underwent polysomnography in the period identified, 104 were diagnosed with OSAS. Monocyte count and MHR values were significantly high (p<0,0001 in both) and HDL levels were significantly low (p=0,03) in OSAS group. There was also a moderately significant positive correlation between apnea-hypopnea index (AHI) and MHR (p<0,0001, r: 0,411). Conclusion: MHR may be a useful tool for diagnosing OSAS. Because of the positive correlation between MHR and AHI which represents the severity of the disease, MHR may be used for the classification of OSAS. Öz Amaç: Obstrüktif uyku apne sendromu (OSAS) uyku ile ilişkili solunum bozuklukları içerisinde en sık görülen hastalıktır. OSAS'ın etyolojisi kesin olarak bilinmemekle birlikte hastalarda sistemik ve havayolunda lokal inflamasyon varlığı gösterilmiştir. Monosit ve makrofajlar inflamasyonda rol alan önemli hücrelerdir. İnflamasyon bölgesinde proinflamatuar sitokinlerin salınmasında görev alırlar. Yüksek dansiteli lipoprotein (HDL) kolesterolü anti inflamatuar etkisi olan bir moleküldür. Monosit/HDL kolesterol oranı (MHO) yakın zamanda kullanılmaya başlanan bir inflamasyon belirtecidir. Çalışmamızda ünitemizde polisomnografi ile OSAS tanısı alanların ve almayanların Ad dress for Cor res pon den ce/Ya zış ma Ad re si:

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Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients

Abstract: Our study demonstrated that a high MHR value is an independent predictor of 30-day mortality in patients with AIS.

Cited by 80 publications

References 25 publications

Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?

Are Monocyte/HDL, Lymphocyte/Monocyte and Neutrophil/Lymphocyte Ratios Prognostic or Follow-up Markers in Ischemic Cerebrovascular Patients?

Monocyte‐to‐HDL‐cholesterol ratio as a prognostic marker in cardiovascular diseases

The Monocyte/HDL Cholesterol Ratio in Obstructive Sleep Apnea Syndrome

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