Monocyte expression of tissue factor and adhesion molecules: the link with accelerated coronary artery disease in patients with chronic renal failure

Al-Saady, N.; Leatham, E; Gupta, Sandeep; Kwan, Jonathan; Eastwood, J. B.; Seymour, Carol A.

doi:10.1136/hrt.81.2.134

Cited by 40 publications

(26 citation statements)

References 47 publications

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“…Al-Saady et al showed a hypercoagulable state in patients with chronic renal failure as a contributing factor for the increased cardiovascular and cerebrovascular event rate [16]. Consistent with with the presentresults, Kappelmayer et al…”

Section: Discussionsupporting

confidence: 92%

Short- and long-term effects of hemodialysis on platelet and monocyte activity markers of atherosclerosis in patients with end-stage renal disease

et al. 2018

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Section: Discussionsupporting

confidence: 92%

Short- and long-term effects of hemodialysis on platelet and monocyte activity markers of atherosclerosis in patients with end-stage renal disease

et al. 2018

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“…3 We demonstrated previously that monocytes of HIV-1-infected patients express high levels of the procoagulant TF and that TF expression is related to viremia and to plasma levels of both sCD14 and D-dimer products of fibrinolysis. 29 TF can initiate the extrinsic clotting pathway, [47][48][49] potentially linking monocyte activation to coagulation and thrombosis in HIV-1 disease.…”

Section: Discussionmentioning

confidence: 99%

Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome

Funderburg

Zidar

Shive

et al. 2012

Blood

186

231

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The mechanisms responsible for increased cardiovascular risk associated with HIV-1 infection are incompletely defined. Using flow cytometry, in the present study, we examined activation phenotypes of monocyte subpopulations in patients with HIV-1 infection or acute coronary syndrome to find common cellular profiles. Nonclassic (CD14+CD16++) and intermediate (CD14++CD16+) monocytes are proportionally increased and express high levels of tissue factor and CD62P in HIV-1 infection. These proportions are related to viremia, T-cell activation, and plasma levels of IL-6. In vitro exposure of whole blood samples from uninfected control donors to lipopolysaccharide increased surface tissue factor expression on all monocyte subsets, but exposure to HIV-1 resulted in activation only of nonclassic monocytes. Remarkably, the profile of monocyte activation in uncontrolled HIV-1 disease mirrors that of acute coronary syndrome in uninfected persons. Therefore, drivers of immune activation and inflammation in HIV-1 disease may alter monocyte subpopulations and activation phenotype, contributing to a pro-atherothrombotic state that may drive cardiovascular risk in HIV-1 infection.

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“…Appropriate inflammation can protect the body against viruses and other unfavorable factors (Keller et al, 2011), but excessive levels of inflammation are associated with increasing severity of CKD in human patients (Al-Saady et al, 1999;Oberg et al, 2004). We speculated that renal impairment in laying hens resulted from an increase in inflammation.…”

Section: Discussionmentioning

confidence: 99%

Effects of taurine and housing density on renal function in laying hens

Zhi-gang

Gao

et al. 2016

J. Zhejiang Univ. Sci. B

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This study investigated the putative protective effects of supplemental 2-aminoethane sulfonic acid (taurine) and reduced housing density on renal function in laying hens. We randomly assigned fifteen thousand green-shell laying hens into three groups: a free range group, a low-density caged group, and a high-density caged group. Each group was further divided equally into a control group (C) and a taurine treatment group (T). After 15 d, we analyzed histological changes in kidney cells, inflammatory mediator levels, oxidation and anti-oxidation levels. Experimental data revealed taurine supplementation, and rearing free range or in low-density housing can lessen morphological renal damage, inflammatory mediator levels, and oxidation levels and increase anti-oxidation levels. Our data demonstrate that taurine supplementation and a reduction in housing density can ameliorate renal impairment, increase productivity, enhance health, and promote welfare in laying hens.

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Monocyte expression of tissue factor and adhesion molecules: the link with accelerated coronary artery disease in patients with chronic renal failure

Abstract: Conclusion-This study has demonstrated a hypercoagulable state in patients with CRF. This was especially pronounced in the dialysis patients. These findings provide a possible explanation for the increased cardiovascular and cerebrovascular morbidity and mortality in these patients.

Cited by 40 publications

References 47 publications

Short- and long-term effects of hemodialysis on platelet and monocyte activity markers of atherosclerosis in patients with end-stage renal disease

Short- and long-term effects of hemodialysis on platelet and monocyte activity markers of atherosclerosis in patients with end-stage renal disease

Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome

Effects of taurine and housing density on renal function in laying hens

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