Monocyte-derived microparticles may be a sign of vascular complication in patients with lung cancer

Kanazawa, Shigenori; Nomura, Shosaku; Kuwana, Midori; Muramatsu, M; Yamaguchi, Kazuyuki; Fukuhara, Shirou

doi:10.1016/s0169-5002(02)00441-5

Cited by 59 publications

(39 citation statements)

References 24 publications

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“…[30][31][32] However, MPs are also released from damaged or inflamed tissues into the blood, providing potential strategies on disease diagnosis. 33,34 Cytoskeletal alteration is a key event involved in the generation of MPs through cellular membrane bubbling and shedding. Therefore, signals that cause the cytoskeletal change might be potential to produce MPs by cells.…”

Section: Discussionmentioning

confidence: 99%

Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression

Chen

et al. 2016

OncoImmunology

105

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Despite identification of macrophages in tumors (tumor-associated macrophages, TAM) as potential targets for cancer therapy, the origin and function of TAM in the context of malignancy remain poorly characterized. Here, we show that microparticles (MPs), as a by-product, released by tumor cells act as a general mechanism to mediate M2 polarization of TAM. Taking up tumor MPs by macrophages is a very efficient process, which in turn results in the polarization of macrophages into M2 type, not only leading to promoting tumor growth and metastasis but also facilitating cancer stem cell development. Moreover, we demonstrate that the underlying mechanism involves the activation of the cGAS/STING/TBK1/STAT6 pathway by tumor MPs. Finally, in addition to murine tumor MPs, we show that human counterparts also possess consistent effect on human M2 polarization. These findings provide new insights into a critical role of tumor MPs in remodeling of tumor microenvironment and better understanding of the communications between tumors and macrophages.

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Section: Discussionmentioning

confidence: 99%

Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression

Chen

et al. 2016

OncoImmunology

105

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“…These particles circulate in the blood and have the ability to mediate both inflammation and thrombosis [25][26][27][28][29][30] . Increased numbers of circulating MPs have been reported in a wide range of diseases 25) , including acute coronary syndrome 31) , infectious diseases 32) , diabetes mellitus 33) , uremia 34) and hematologic 35,36) and other malignancies 37,38) . However, it is not currently known whether MPs may be used as biomarkers for predicting the presence of CRS and/or cardiorenal disease (CRD).…”

Section: Blood Sampling For Biochemistry Blood Cell Count Study and mentioning

confidence: 99%

Levels of Circulating Microparticles in Patients with Chronic Cardiorenal Disease

Chen

Wallace

et al. 2015

JAT

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Aim: Cardiac and renal diseases are common disorders that frequently coexist. We tested the hypothesis that the levels of circulating endothelial-derived apoptotic microparticles (EDA-MPs; CD31 CD42b AN V ) and platelet-derived apoptotic microparticles (PDA-MPs; CD31 CD42b AN V ) are useful biomarkers for predicting the presence of cardiorenal disease (CRD). Methods: A total of 68 patients with chronic kidney disease (CKD) and angina pectoris (CKD-AP) undergoing cardiac catheterization were prospectively enrolled into group 1, 10 patients with coronary artery disease (CAD) without CKD were enrolled into group 2 (CAD CKD ) and 10 patients without CAD and CKD were enrolled into group 3 (CAD CKD ). Results: The serum creatinine levels were significantly higher, whereas the estimated glomerular filtration rates (eGFRs) were significantly lower, in group 1 than in the other two groups (all p 0.02). The circulating levels of EDA-MPs and PDA-MPs did not differ between the patients with and without CKD (all p 0.2). However, the circulating levels of EDA-MPs and PDA-MPs were significantly higher in group 2 than in groups 1 and 3 (all p 0.03). In addition, differences were noted in the circulating EDA-MP and PDA-MP levels between groups 1 and 3, although without statistical significance (all p 0.09). Meanwhile, among the CKD patients, the subgroup analysis showed that the levels of MPs were significantly higher in those with CAD than in those without (all p 0.001), while a multivariate analysis demonstrated that CAD was the only factor independently predictive of high levels of circulating EDA-MPs and PDA-MPs (p 0.033). Conclusions:The link with increased circulating levels of MPs is more consistent in patients with CAD than in those with CKD. J Atheroscler Thromb, 2015; 22: 247-256.

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“…Accumulating published data demonstrates that numbers of circulating MPs are increased in a wide range of diseases [14, 24–30], including LC [31]. We also recently demonstrated that circulating levels of MPs are significantly increased in LC patients, and circulating levels of endothelial-derived apoptotic MPs (EDAp-MPs) are significantly associated with different LC cell types [32].…”

Section: Introductionmentioning

confidence: 99%

Circulating Endothelial-Derived Activated Microparticle: A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer

Wang

Tseng

Hsiao

et al. 2014

BioMed Research International

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Background. This study tested the hypothesis that circulating microparticles (MPs) are useful biomarkers for predicting one-year mortality in patients with end-stage non-small cell lung cancer (ES-NSCLC). Methods and Results. One hundred seven patients were prospectively enrolled into the study between April 2011 and February 2012, and each patient received regular follow-up after enrollment. Levels of four MPs in circulation, (1) platelet-derived activated MPs (PDAc-MPs), (2) platelet-derived apoptotic MPs (PDAp-MPs), (3) endothelial-derived activated MPs (EDAc-MPs), and (4) endothelial-derived apoptotic MPs (EDAp-MPs), were measured just after the patient was enrolled into the study using flow cytometry. Patients who survived for more than one year were categorized into group 1 (n = 56) (one-year survivors) and patients who survived less than one year were categorized into group 2 (n = 51) (one-year nonsurvivors). Male gender, incidence of liver metastasis, progression of disease after first-line treatment, poor performance status, and the Charlson comorbidity index were significantly higher in group 2 than in group 1 (all P < 0.05). Additionally, as measured by flow cytometry, only the circulating level of EDAc-MPs was found to be significantly higher in group 2 than in group 1 (P = 0.006). Multivariate analysis demonstrated that circulating level of EDAc-MPs along with brain metastasis and male gender significantly and independently predictive of one-year mortality (all P < 0.035). Conclusion. Circulating EDAc-MPs may be a useful biomarker predictive of one-year morality in ES-NSCLC patients.

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Monocyte-derived microparticles may be a sign of vascular complication in patients with lung cancer

Cited by 59 publications

References 24 publications

Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression

Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression

Levels of Circulating Microparticles in Patients with Chronic Cardiorenal Disease

Circulating Endothelial-Derived Activated Microparticle: A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer

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