Monocyte-derived IL12, CD86 (B7-2) and CD40L expression in relapsing and progressive multiple sclerosis

Filion, Lionel G.; Matusevičius, Darius; Graziani-Bowering, Gina M; Kumar, Ashok; Freedman, Mark S.

doi:10.1016/s1521-6616(02)00028-1

Cited by 59 publications

(40 citation statements)

References 35 publications

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“…CD40 was expressed on macrophages and microglia, whereas CD154 colocalized with the CD4 T-cell marker. 123 Expression of CD154 was found to be higher in peripheral blood monocytes isolated from secondary progressive MS compared with relapsing-remitting MS or healthy control subjects 129,130 and was reduced by IFN-γ treatment. 131 PBMCs from patients with SPMS produced more IL-12 and IFN-γ when restimulated in vitro compared with those from healthy control subjects.…”

Section: Cd40-cd154 In Msmentioning

confidence: 98%

Role of costimulatory pathways in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis

Chitnis

Khoury

2003

Journal of Allergy and Clinical Immunology

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Section: Cd40-cd154 In Msmentioning

confidence: 98%

Role of costimulatory pathways in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis

Chitnis

Khoury

2003

Journal of Allergy and Clinical Immunology

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“…In addition, CD40 ligation on dendritic cells leads these cells to maturation to express an antigen-presenting phenotype. CD40L has also been found to be expressed on a variety of other cell types such as platelets, B cells, mast cells, basophils and natural killer cells in many diseases [1], and CD40-CD40L interaction is involved in many autoimmune diseases, such as systemic lupus erythematosus [8], rheumatoid arthritis [9], systemic sclerosis [10], primary Sjögren’s syndrome [11], multiple sclerosis [12], inflammatory bowel diseases [13], chronic urticaria [14], and in allograft rejection [15]. Collectively, the disruption of the CD40-CD40L pathway is critically related to the manifestation of autoimmune diseases and has been considered as a promising therapeutic target.…”

Section: Introductionmentioning

confidence: 99%

Increased Serum Levels of Circulating CD40 Ligand in Patients with Bullous Pemphigoid: Preliminary Results

Watanabe

Ishiura²,

Nakashima³

et al. 2007

Dermatology

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Background: Autoimmune bullous diseases are characterized by autoantibodies against specific adhesion molecules of the skin and/or mucous membrane. While these autoantibodies are known to play a primary role in the disease manifestation, it remains unknown how disease-specific autoreactive B cells and autoantibodies are induced. Recent studies have indicated the importance of the CD40 and CD40 ligand (CD40L) receptor-ligand pair in the immunopathogenesis of autoimmune diseases. CD40L circulates in soluble form, and some reports suggest that serum soluble CD40L (sCD40L) levels are increased in various autoimmune diseases. Objectives: To determine serum sCD40L levels in patients with pemphigus vulgaris (PV) and bullous pemphigoid (BP), and to determine their correlation with clinical findings and laboratory findings. Patients and Methods: Sera from 10 PV patients, 35 BP patients and 12 normal controls were subjected to ELISA assays to measure serum levels of sCD40L, anti-desmoglein-3 antibody and anti-BP180 antibody. Results and Conclusions: Circulating sCD40L levels were significantly elevated in BP patients, but not in PV patients. Serum sCD40L levels increased in the early stage of disease onset and recurrence in BP patients. In conclusion, circulating sCD40L levels may be a useful marker for early activation of autoimmune diathesis and, furthermore, an effective therapeutic target in patients with BP.

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“…Among the genes in the consensus region of chromosome 5, IL12 outstands as a proinflammatory cytokine already described as relevant to MS 41 and TCF7 and ITK also mediate in T-cell activity. 42,43 RAB27 is an interesting candidate gene located in the small consensus of chromosome 18.…”

Section: Mhc Consensusmentioning

confidence: 99%

Intergenomic consensus in multifactorial inheritance loci: the case of multiple sclerosis

Serrano-Fernández

Ibrahim

et al. 2004

Genes Immun

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Genetic linkage and association studies define chromosomal regions, quantitative trait loci (QTLs), which influence the phenotype of polygenic diseases. Here, we describe a global approach to determine intergenomic consensus of those regions in order to fine map QTLs and select particularly promising candidate genes for disease susceptibility or other polygenic traits. Exemplarily, human multiple sclerosis (MS) susceptibility regions were compared for sequence similarity with mouse and rat QTLs in its animal model experimental allergic encephalomyelitis (EAE). The number of intergenomic MS/EAE consensus genes (295) is significantly higher than expected if the animal model was unrelated to the human disease. Hence, this approach contributes to the empirical evaluation of animal models for their applicability to the study of human diseases.

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Monocyte-derived IL12, CD86 (B7-2) and CD40L expression in relapsing and progressive multiple sclerosis

Cited by 59 publications

References 35 publications

Role of costimulatory pathways in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis

Role of costimulatory pathways in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis

Increased Serum Levels of Circulating CD40 Ligand in Patients with Bullous Pemphigoid: Preliminary Results

Intergenomic consensus in multifactorial inheritance loci: the case of multiple sclerosis

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