Monocyte Cytokine Production in an Elderly Population: Effect of Age and Inflammation

Roubenoff, Ronenn; Harris, Tamara B.; Abad, Leslie W.; Wilson, Peter W.F.; Dallal, Gerard E.; Dinarello, Charles A.

doi:10.1093/gerona/53a.1.m20

Cited by 374 publications

(249 citation statements)

References 39 publications

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“…Even though cytokine levels may differ in elderly patients, it seems unlikely that the greater age in this patient group is decisive for the observed mismatch in IL-1b and IL-1RA secretion. Population studies revealed increased production of IL-1RA from blood mononuclear cells in the elderly, whereas IL-1b levels remained unchanged on ageing [23].…”

Section: Discussionmentioning

confidence: 97%

Imbalanced secretion of IL-1 and IL-1RA in Chlamydia pneumoniae-infected mononuclear cells from COPD patients

Rupp

Kothe²,

Mueller³

et al. 2003

European Respiratory Journal

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Balanced secretion of pro-and anti-inflammatory cytokines is essential in limiting pulmonary inflammation in respiratory infections. It was hypothesised that, in acute infection with Chlamydia pneumoniae, mononuclear cells from chronic obstructive pulmonary disease (COPD) patients lack the opportunity to compensate for the inflammatory immune response by secreting adequate amounts of anti-inflammatory cytokines.Alveolar macrophages (AMs) and peripheral blood mononuclear cells (PBMCs) from eight COPD patients and eight healthy controls were infected with C. pneumoniae in order to determine interleukin (IL)-1b, IL-1 receptor antagonist (IL-1RA) and IL-8 expression and messenger ribonucleic acid levels.Secretion of IL-1b was significantly enhanced in AMs (six-fold) and PBMCs (four-fold) from COPD patients after infection with C. pneumoniae. Compared to the control group, release of its anti-inflammatory counterpart IL-1RA was diminished in COPD patients, resulting in a significantly higher IL-1b/IL-1RA ratio in C. pneumoniae-infected AMs and PBMCs from COPD patients.Mononuclear cells from chronic obstructive pulmonary disease patients have less capacity for balancing the pro-inflammatory immune response caused by Chlamydia pneumoniae infection than those from healthy controls. These findings suggest that, during acute exacerbation with intracellular pathogens, chronic obstructive pulmonary disease patients are predisposed to inflammatory changes in the lungs. Eur Respir J 2003; 22: 274-279.

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Section: Discussionmentioning

confidence: 97%

Imbalanced secretion of IL-1 and IL-1RA in Chlamydia pneumoniae-infected mononuclear cells from COPD patients

Rupp

Kothe²,

Mueller³

et al. 2003

European Respiratory Journal

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“…In fact, ox-LDL has also been shown to stimulate IL-6 expression (Massy et al 2000) and IL-1β release (Thomas et al 1994). Additionally, in vitro studies have shown that monocytes from elderly individuals are in a preactivated state; there is greater initial production of proinflammatory cytokines, but there is no difference in the peak levels of cytokines among elderly and younger subjects (Ahluwalia et al 2001;Roubenoff et al 1998). …”

Section: Discussionmentioning

confidence: 99%

Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women

Kim

Chae

Paik

et al. 2011

AGE

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Inappropriate interleukin-6 production is thought to play a role in the development of several age-related conditions including atherosclerosis. This study aimed to determine whether aging affects circulating interleukin-6 (IL-6) levels. Healthy, nonobese women (n = 208, 44.5 ± 0.70 years, 22.4 ± 0.17 kg/m 2 ) were categorized into four age groups (22-31, 32-41, 42-51, and 52-63 years; crosssectional study). Cytokine levels in serum and those produced from peripheral blood mononuclear cell (PBMC) were measured. The oldest group had the highest circulating levels of IL-6 and oxidized lowdensity lipoprotein (ox-LDL) and higher PBMC production of IL-6, tumor necrosis factor-α (TNF-α), and interleukin-1 alpha (IL-1β). Additionally, significant interactions between age and menopause were found for serum IL-6 (P=0.024), and TNF-α (P= 0.011) and IL-1β (P<0.001) produced from PBMCs. Serum IL-6 levels positively correlated with age, waist-hip ratio (WHR), systolic blood pressure, circulating levels of TNF-α, IL-1β, and ox-LDL, and urinary 8-epi-prostaglandin F 2 α. Multiple stepwise AGE (2012) 34:415-425

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“…The data regarding cytokine and chemokine secretion are ambiguous in several studies using human monocytes from aged or young individuals activated in vitro with mitogens or LPS. Although the majority of the studies indicate an increase in the levels of pro-inflammatory factors such as IL-6 and IL-8 (Ershler et al ., 1993;Clark & Peterson, 1994;O'Mahony et al ., 1998;Roubenoff et al ., 1998;Sadeghi et al ., 1999;Hasegawa et al ., 2000;Mariani et al ., 2002), others find decreased levels (Gon et al ., 1996;Beharka et al ., 2001) or no changes at all (Ahluwalia et al ., 2001). Differences in the genetic heterogeneity and health status of the test population, in addition to the experimental and assay conditions, may all contribute to the discrepancy in these results.…”

Section: Cytokine and Chemokine Secretionmentioning

confidence: 99%

Innate immunity in aging: impact on macrophage function

et al. 2004

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SummaryInnate and adaptive immune functions decline with age, leading to increased susceptibility to infectious diseases and cancer, and reduced responses to preventive vaccination in the elderly population. Macrophages function as 'pathogen sensors' and play an important role in the initiation of inflammatory responses, elimination of pathogens, manipulation of the adaptive immune response and reparation of damaged tissue. In this paper, we review the literature addressing the impact of aging on the macrophage population.

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Monocyte Cytokine Production in an Elderly Population: Effect of Age and Inflammation

Cited by 374 publications

References 39 publications

Imbalanced secretion of IL-1 and IL-1RA in Chlamydia pneumoniae-infected mononuclear cells from COPD patients

Imbalanced secretion of IL-1 and IL-1RA in Chlamydia pneumoniae-infected mononuclear cells from COPD patients

Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy nonobese women

Innate immunity in aging: impact on macrophage function

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