Monocyte Chemoattractant Protein-1 Concentration in Coronary Sinus Blood and Severity of Coronary Disease

Circulating chemokines in relation to coronary plaque characteristics on radiofrequency intravascular ultrasound and cardiovascular outcome

“…We found that higher plasma MCP-1 concentrations were associated with higher coronary plaque burden in patients who were admitted with stable angina pectoris. These findings are in line with a previous study that measured MCP-1 concentrations in blood from the coronary sinus and found that these levels were associated with the extent of coronary atherosclerosis as assessed on the coronary angiogram (Serrano-Martinez et al, 2003). Although we observed that high MCP-1 concentrations were associated with a more advanced plaque phenotype (i.e.…”

Intracoronary Monocyte Chemoattractant Protein 1 and Vascular Endothelial Growth Factor Levels Are Associated with Necrotic Core, Calcium and Fibrous Tissue Atherosclerotic Plaque Components: An Intracoronary Ultrasound Radiofrequency Study

“…Coronary sinus levels of MCP-1 and tissue expression of VEGF in human atherosclerotic plaques suggest a possible relationship between local concentrations of each of these biomarkers and the extent of atherosclerosis [19,20,21,23]. Of interest, in this regard, is our observation of associations between VEGF levels and plaque burden and between MCP-1 and VEGF levels and the degree of MLA stenosis.…”

Inflammatory Biomarkers in Acute Coronary Syndromes

“…9 Measurement of MCP-1 in the coronary sinus blood of patients with unstable angina demonstrated an association between MCP-1 levels and the extent of coronary atherosclerosis as assessed by the coronary angiogram. 10 Although levels of MCP-1 may be primarily a surrogate for atherosclerotic burden, MCP-1 remains a promising therapeutic target with a compelling pathophysiological role in atherothrombosis.…”