Monocyte chemoattractant protein–1 −2518 A/G single nucleotide polymorphism in Chinese Han patients with ocular Behçet's disease

Promoter –2518 single nucleotide polymorphism of monocyte chemoattractant protein-1 is associated with clinical severity in Behçet’s disease

“…The present study found slightly more frequent G allele than A allele in both BD patients and controls. This was also compatible with results from the recent Chinese Han study [12]. These findings might suggest larger regional or ethnic variation in prevalence of promoter -2518 polymorphism of MCP-1.…”

“…Second, there is a racial or ethnic heterogeneity of the G allele at position -2518 in MCP-1, suggesting that racial differences might lead to changes in MCP-1 production in response to various stimuli. Hou et al [12] did not demonstrate increased susceptibility of the GG genotype in the ocular form of BD. Third, although MCP-1 is a potent chemokine involved in the pathogenesis of BD, the relationship between MCP-1 and its receptor, CCR2, should be considered.…”

“…Some investigations on the influence of MCP-1 -2518 polymorphism on either the susceptibility or the clinical features in BD have been reported in different Asian populations [10,12]. However, the clinical effect of this polymorphism on BD severity has not been clearly determined.…”

“…Therefore, it is crucial to note that MCP-1 might be mostly related to the pathogenesis of BD. Based on the strong involvement of MCP-1 in the pathogenesis of BD, association between -2518 MCP-1 gene polymorphism and BD was found in both Chinese Han [12] and Korean populations [10].The Asian population with prominence of the G allele was quite different from the Western population with A allele dominance in the genotypic prevalence of promoter -2518 of the MCP-1 gene polymorphism [10,20]. The present study found slightly more frequent G allele than A allele in both BD patients and controls.…”

“…However, in the literature, there are contrasting findings showing no significant differences in serum MCP-1 levels between BD and either familial Mediterranean fever or healthy controls [11]. In two clinical studies, some relationship between polymorphism at promoter -2518 locus of the MCP-1 gene and a few clinical symptoms of BD, including ocular or gastrointestinal involvement, was demonstrated [10,12]. These findings may suggest an association between MCP-1 polymorphism and the presence of severe features in BD.…”