Monoclonality of Asynchronous Bilateral Lymphoma of the Testis

Leite, Kátia Ramos Moreira; Garicochea, Bernardo; Srougi, Miguel; Dzik, Carlos; Nesralhah, Luciano; Moura, Ricardo Pereiro de; Simpson, Andrew; Darini, Elaine; Carvalho, Claudia M.; Câmara-Lopes, Luiz H.

doi:10.1159/000020378

Cited by 12 publications

(6 citation statements)

References 15 publications

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“…Immunophenotypic features in PTL are similar to those reported for the same histological categories arising in lymph nodes or other extranodal organs. Monoclonal lymphoid cells have been shown in controlateral testis in PTL patients, suggesting that bilateral testicular involvement is a pattern of a disease of the same origin [12]. Similarly to those reported for extranodal marginal zone lymphoma, somatic hypermutations of immunoglobulin heavy-chain gene have been described in PTL, indicating a possible antigen-driven stimulation in these lymphomas [13].…”

Section: Pathologymentioning

confidence: 52%

Primary testicular lymphoma

Vitolo

Ferreri²,

Zucca

2008

Critical Reviews in Oncology/Hematology

105

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Section: Pathologymentioning

confidence: 52%

Primary testicular lymphoma

Vitolo

Ferreri²,

Zucca

2008

Critical Reviews in Oncology/Hematology

105

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“…Non-Hodgkin B-cell lymphoma is the most common testicular malignancy in men older than 60 years (45). At US, testicular lymphoma is hypoechoic and hypervascular, similar to both seminoma and epididymo-orchitis (46) (Fig 15).…”

Section: Lymphomamentioning

confidence: 99%

Testicular Seminoma and Its Mimics:From the Radiologic Pathology Archives

Marko¹,

Wolfman²,

Aubin³

et al. 2017

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Testicular seminoma is the most common malignant tumor of the testis. It classically manifests as a painless mass. Radiologic evaluation with high-frequency ultrasonography (US) is critical for diagnosis. Seminomas are usually homogeneously hypoechoic masses at US. In challenging cases, magnetic resonance (MR) imaging may help confirm that a mass is intratesticular and provide data for local staging. Computed tomography (CT) provides valuable information for staging, including the presence and size of retroperitoneal lymph nodes. Testicular seminoma is treated with radical inguinal orchiectomy and is highly curable even at advanced stages of disease. Several neoplastic and nonneoplastic conditions may mimic testicular seminoma at imaging. Benign mimics include segmental infarction, hematoma, infection, epidermoid cyst, adrenal rests, sarcoidosis, splenogonadal fusion, and sex cord-stromal tumors. Malignant mimics include nonseminomatous germ cell tumors, lymphoma, and metastases. These conditions are individually reviewed with emphasis on features that allow differentiation from seminoma. Spermatocytic tumor, formerly known as spermatocytic seminoma, accounts for only 1% of testicular tumors. It is distinct from classic seminoma, with unique histologic, molecular, and genetic features. It affects an older patient population than classic seminoma and demonstrates indolent clinical behavior. Radiologists serve a key role in diagnosis, staging, and surveillance of patients with seminoma. A thorough knowledge of related clinical, radiologic, and pathologic findings will help the radiologist contribute to high-quality interdisciplinary care of affected patients.

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“…The testes may be affected by systemic hematologic diseases such as leukemia and lymphoma or may be affected by metastasizing extratesticular solid tumors. Non‐Hodgkin B‐cell lymphoma is the most frequent testicular malignancy in patients older than 60 years, which is typically unilateral and usually painless (Figure ) . The testicular manifestations of lymphomas and leukemias present on US images as unifocal or multifocal hypoechoic and hypervascularized lesions .…”

Section: Secondary Testicular Tumorsmentioning

confidence: 99%

Overview of ultrasound applications for assessing scrotal disorders

Schwarze

Marschner

Rübenthaler

et al. 2019

J of Ultrasound Medicine

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The scrotum may be affected by a plethora of different disorders such as infections, vasculopathies, trauma, and manifestations of primary and secondary malignant masses. In addition to the patient's medical history and clinical examination, ultrasound represents the imaging modality of choice to assess scrotal disorders. Timeconsuming contrast-enhanced ultrasound and elastography can provide further information to distinguish between benign and malignant testicular mass lesions. The following invited Special Communication gives a comprehensive overview of differential diagnoses of the scrotum and their corresponding sonomorphologic correlates based on representative cases of the Interdisciplinary Ultrasound Center of the University Hospital Munich.

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Monoclonality of Asynchronous Bilateral Lymphoma of the Testis

Cited by 12 publications

References 15 publications

Primary testicular lymphoma

Primary testicular lymphoma

Testicular Seminoma and Its Mimics:From the Radiologic Pathology Archives

Overview of ultrasound applications for assessing scrotal disorders

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