Monoclonal Epstein‐Barr virus genomes but lack of EBV‐related protein expression in different types of gastric carcinoma

Ott, German; Kirchner, T.; Müller-Hermelink, H. K.

doi:10.1111/j.1365-2559.1994.tb01350.x

Cited by 74 publications

(63 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Clinicopathologic findings such as cardia location, diffuse histology and weak male predominance are different from those described in previous studies, 10,11,16,18,19 but similar to those conducted in Mexico 41 and to Mexican descendants living in the U.S. 42 suggesting unique characteristics of EBV-associated GC in Latin-America. Further research in other Latin-American countries will be necessary to confirm these findings.…”

Section: Factors Associated With Ebv Positive Casessupporting

confidence: 46%

Epstein‐Barr virus in gastric carcinoma is associated with location in the cardia and with a diffuse histology: A study in one area of Chile

et al. 2001

View full text Add to dashboard Cite

Epstein-Barr virus (EBV) has been associated with the most common form of stomach neoplasms, the gastric carcinoma (GC). The presence of EBV-encoded small RNAtype-1 (EBER-1), a marker for EBV infection was analyzed by in situ hybridization (ISH) in 185 formalin-fixed and paraffinembedded cases of GC from a high risk region. We found 31 (16.8%) EBV-positive cases with no relationship to age. Although male predominance (19% in males and 12.5% in females) was observed, the gender difference did not achieve statistical significance. Odds ratio (OR) for cardia location was 5.4 (95% CI 1.7-17.3) when antrum was used as referent category and the effects of gender and age were taken into account. The proportion of EBV-positive cases in diffuse histology was higher than intestinal type (OR ‫؍‬ 4.8, 95% CI ‫؍‬ 2.0 -11.1). Our findings are contrary to a previously accepted hypothesis, that high-risk countries for GC have low rates of EBV-associated GC. In addition, our findings regarding location, histology and weak male predominance are different from what has been described in Asian and European countries, but similar to those described in Mexico and Mexican descendants living in the U.S. suggesting unique characteristics of EBV-associated GC in Latin-America.

show abstract

Section: Factors Associated With Ebv Positive Casessupporting

confidence: 46%

Epstein‐Barr virus in gastric carcinoma is associated with location in the cardia and with a diffuse histology: A study in one area of Chile

et al. 2001

View full text Add to dashboard Cite

show abstract

“…The frequency of EBV-positive gastric carcinomas can reach up to 18% (19,21,23,(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39), as reported in Germany (39). In Eastern countries, e.g., Japan, China and Taiwan, EBV-positive gastric cancer comprises 5.6 to 13.5% of cases (19,21,(29)(30)(31)(32)(33)(34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil

Lopes

Bacchi

Oliveira

et al. 2004

Braz J Med Biol Res

View full text Add to dashboard Cite

Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, and most people have serological evidence of previous viral infection at adult age. EBV is associated with infectious mononucleosis and human cancers, including some lymphomas and gastric carcinomas. Although EBV was first reported in lymphoepithelioma-like gastric carcinoma, the virus was also found in conventional adenocarcinomas. In the present study, 53 gastric carcinomas diagnosed in São Paulo State, Brazil, were evaluated for EBV infection by non-isotopic in situ hybridization with a biotinylated probe (Biotin-AGACACCGTCCTCACCACCC GGGACTTGTA) directed to the viral transcript EBER-I, which is actively expressed in EBV latently infected cells. EBV infection was found in 6 of 53 (11.32%) gastric carcinomas, mostly from male patients (66.7%), with a mean age of 59 years old. Most EBV-positive tumors were in gastric antrum. Two EBV-positive tumors (33.3%) were conventional adenocarcinomas, whereas four (66.7%) were classified as lymphoepithelioma-like carcinomas. EBV infection in gastric carcinomas was reported elsewhere in frequencies that range from 5.6% (Korea) up to 18% (Germany). In Brazil, a previous work found EBV infection in 4 of 80 (5%) gastric carcinomas, whereas another study found 4.7 and 11.2% of EBV-positive gastric carcinomas of Brazilians of Japanese origin or not, respectively. In the present study, the frequency of EBV-positive gastric carcinomas is similar to that reported in other series, and the clinicopathologic characteristics of these EBV-positive tumors are in agreement with the data in the literature. Correspondence

show abstract

“…Although MI was noted in a high percentage of gastric cancers with a positive family history (Akiyama et al, 1996;Keller et al, 1996;Ottini et al, 1997), germline or somatic mutations of the mismatch repetition and repair (MMR) genes were rarely reported (Akiyama et al, 1996;Keller et al, 1996). Thus, the mechanism leading to the mismatch repair failure in gastric carcinomas remains largely unknown.The association between EpsteinÐBarr virus (EBV) and gastric cancer also varies among different populations, with the highest positive association occurring in Caucasian populations (Shibata and Weiss, 1992;Ott et al, 1994) and a low association seen in the Japanese (Tokunaga et al, 1993). EBV is found in more than 80% of a specific histological variant of gastric carcinoma, variably termed lymphoepithelioma-like carcinoma (LELC), medullary or gastric carcinoma with lymphoid stroma (Nakamura et al, 1994).…”

mentioning

confidence: 99%

“…The association between EpsteinÐBarr virus (EBV) and gastric cancer also varies among different populations, with the highest positive association occurring in Caucasian populations (Shibata and Weiss, 1992;Ott et al, 1994) and a low association seen in the Japanese (Tokunaga et al, 1993). EBV is found in more than 80% of a specific histological variant of gastric carcinoma, variably termed lymphoepithelioma-like carcinoma (LELC), medullary or gastric carcinoma with lymphoid stroma (Nakamura et al, 1994).…”

mentioning

confidence: 99%

Microsatellite instability, Epstein–Barr virus, mutation of type II transforming growth factor β receptor and BAX in gastric carcinomas in Hong Kong Chinese

et al. 1999

View full text Add to dashboard Cite

Microsatellite instability (MI), the phenotypic manifestation of mismatch repair failure, is detectable in a wide variety of human cancers. It is particularly seen in patients with the hereditary non-polyposis colon cancer (HNPCC) syndrome, in which the affected individual is at risk of developing carcinoma both at an early age and at a range of sites such as the colon, endometrium, urinary tract and stomach (Aaltonen et al, 1993;Marra and Boland, 1995;Lynch et al, 1996). Germline mutation in one of the DNA mismatch repair genes is responsible for a significant proportion of individuals affected by this syndrome (Fishel et al, 1993;Bronner et al, 1994;Liu et al, 1994;Nicolaides et al, 1994;Papadopoulos et al, 1994). MI has also been detected in a variable proportion of the sporadic form of cancer arising in these organs (Eshleman and Markowitz, 1995).Although gastric cancer, worldwide, is deemed to be both the second most common malignancy and second leading cause of cancer death Pisani et al, 1993), the incidence varies markedly in different populations. The incidence of molecular genetic changes is known to vary; for example, the series of reports from high incidence areas such as Japan, Italy, Portugal and Korea show a range for MI varying from 15% to 39% (Han et al, 1993;Chong et al, 1994;Rhyu et al, 1994;Strickler et al, 1994;Lin et al, 1995;Chung et al, 1996;dos Santos et al, 1996;Ohue et al, 1996;Renault et al, 1996). Although MI was noted in a high percentage of gastric cancers with a positive family history (Akiyama et al, 1996;Keller et al, 1996;Ottini et al, 1997), germline or somatic mutations of the mismatch repetition and repair (MMR) genes were rarely reported (Akiyama et al, 1996;Keller et al, 1996). Thus, the mechanism leading to the mismatch repair failure in gastric carcinomas remains largely unknown.The association between EpsteinÐBarr virus (EBV) and gastric cancer also varies among different populations, with the highest positive association occurring in Caucasian populations (Shibata and Weiss, 1992;Ott et al, 1994) and a low association seen in the Japanese (Tokunaga et al, 1993). EBV is found in more than 80% of a specific histological variant of gastric carcinoma, variably termed lymphoepithelioma-like carcinoma (LELC), medullary or gastric carcinoma with lymphoid stroma (Nakamura et al, 1994). This variant is characterized by the presence of a poorly differentiated morphology, a circumscribed border, an intense lymphoid reaction and a better prognosis (Watanabe et al, 1976). The possible relationship between EBV, MI and LELC is largely unexplored except in one study from Japan, in which all eight EBV-associated gastric cancers were negative for MI (Chong et al, 1994).Previous data have shown that the mutator phenotype conferred by MI has a significant role in carcinogenesis, in which it targets Microsatellite instability, EpsteinÐBarr virus, mutation of type II transforming growth factor β receptor and BAX in gastric carcinomas in Hong Kong Chinese Summary Microsatellite instability (M...

show abstract

Monoclonal Epstein‐Barr virus genomes but lack of EBV‐related protein expression in different types of gastric carcinoma

Cited by 74 publications

References 30 publications

Epstein‐Barr virus in gastric carcinoma is associated with location in the cardia and with a diffuse histology: A study in one area of Chile

Epstein‐Barr virus in gastric carcinoma is associated with location in the cardia and with a diffuse histology: A study in one area of Chile

Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil

Microsatellite instability, Epstein–Barr virus, mutation of type II transforming growth factor β receptor and BAX in gastric carcinomas in Hong Kong Chinese

Contact Info

Product

Resources

About