Monoclonal Autoantibody Against a Cryptic Epitope on Tissue-Adherent Low-Density Lipoprotein for Molecular Imaging in Atherosclerosis

Khamis, Ramzi; Hartley, Adam; Caga-Anan, Mikhail; Pandey, Samata; Marceddu, Cinzia; Kojima, Chiari; Chang, Shang‐Hung; Boyle, Joseph J.; Johnson, Jason L.; Björkbacka, Harry; Guo, Liang; Finn, Aloke V.; Virmani, Renu; Nilsson, Jan; Haskard, Dorian O.

doi:10.1016/j.jcmg.2022.02.023

Cited by 2 publications

(2 citation statements)

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“…Oxidized low density lipoprotein (ox-LDL) is the main target of molecular imaging of atherosclerosis and plays an important role in the formation of plaque. [83] Oxidized low-density lipoprotein (ox-LDL) is more easily recognized by the scavenger receptor of macrophages than the natural LDL, leading to the imbalance of lipid metabolism in macrophages. [84,85] In addition, the level of oxidized low density lipoprotein also reflects the vulnerability of plaque.…”

Section: Targeted Imaging Of Lipidsmentioning

confidence: 99%

“…Endothelial dysfunction weak acid environment pH PCN-NP-HPZ [59] NO and eNOX NO DHP-4 [127] NO-QA 5 [128] APNO-5 [65] NO NS1 [34] The macrophages engulf ox-LDL active oxygen H 2 O 2 BSAÀ Cy-Mito [72] Au@MnO 2 @Raman reporter [129] NATPA [73] HClO MTBÀ B-CF 3 [75] NB 4 OH [76] S-ClO [130] O 2 *À RSPN [79] Gol ROS [131] ONOO À Mito-WQPhOH [82] MOÀ E2 [132] LDL LDL LO9 [83] ox-LDL LO1 [93] endothelial cell ICAM-1 RB700 [133] CD36 Ru(bpy) 3 @SiO 2 -SiO 2 [122] UCNPs@SiO 2 -CD36) [134] MMR MMR-NIRF [123] MMR-Lobe-Cy [135] myeloperoxidase FD-301 [102] heMAMP [50] Foam cell formation foam cell osteopontin UCNP-anti-OPN [125] TPZ/IR780@HAS•OPN [136] foam cell PM-PAAO-UCNPs [126] lipid LDs CNÀ N2 [94] CN-PD [137] lipid microenvironment LDs-DM [95] IND [138] extracellular matrix MMP2 AuNRs-Abs [46] cysteine protease P-ICG2-PS Lip [103] senescent cell β-galactosidase BODÀ L-βGa [104] ChemBioChem Through the differences between the response signals from different fluorophores and markers, we can carry out statistical analysis of the data, and then obtain a two-dimensional fluorescence spectrum of the substance to be measured. In conclusion, the design of multicomponent detection and imaging probes for early evaluation of atherosclerosis will be a very promising direction.…”

Section: As Development Stagementioning

confidence: 99%

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Detection and Imaging of Active Substances in Early Atherosclerotic Lesions Using Fluorescent Probes

Zhang

et al. 2023

ChemBioChem

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Atherosclerosis (AS) is a vascular disease caused by chronic inflammation and lipids that is the main cause of myocardial infarction, stroke and other cardiovascular diseases. Atherosclerosis is often difficult to detect in its early stages due to the absence of clinically significant vascular stenosis. This is not conducive to early intervention or treatment of the disease. Over the past decade, researchers have developed various imaging methods for the detection and imaging of atherosclerosis. At the same time, more and more biomarkers are being found that can be used as targets for detecting atherosclerosis. Therefore, the development of a variety of imaging methods and a variety of targeted imaging probes is an important project to achieve early assessment and treatment of atherosclerosis. This paper provides a comprehensive review of the optical probes used to detect and target atherosclerosis imaging in recent years, and describes the current challenges and future development directions.

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Section: Targeted Imaging Of Lipidsmentioning

confidence: 99%