1985
DOI: 10.1073/pnas.82.21.7409
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Monoclonal antibody that defines human myoepithelium.

Abstract: We have isolated a mouse monoclonal antibody that, upon immunohistochemical localization in frozen sections, displays specificity for human myoepithelial cells in the resting mammary gland, sweat glands, and salivary glands. Furthermore, this antibody was strongly and homogeneously reactive with frozen sections of 3 of 60 breast carcinoma specimens. Using immunolocalization techniques in conjunction with polyacrylamide gel electrophoresis, we have determined that the reactivity of this monoclonal antibody is d… Show more

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Cited by 90 publications
(37 citation statements)
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References 16 publications
(11 reference statements)
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“…A landmark paper in 1985 reported the first reliable staining of the basal/myoepithelial lineage within the human breast (Dairkee et al 1985). Surprisingly, a fraction of cancer cells also stained with the keratin 14 antibody in a subset of breast carcinomas, but the majority displayed a luminal staining pattern.…”
Section: Cytokeratin Staining Patterns In Normal and Neoplastic Breasmentioning
confidence: 99%
See 1 more Smart Citation
“…A landmark paper in 1985 reported the first reliable staining of the basal/myoepithelial lineage within the human breast (Dairkee et al 1985). Surprisingly, a fraction of cancer cells also stained with the keratin 14 antibody in a subset of breast carcinomas, but the majority displayed a luminal staining pattern.…”
Section: Cytokeratin Staining Patterns In Normal and Neoplastic Breasmentioning
confidence: 99%
“…Surprisingly, a fraction of cancer cells also stained with the keratin 14 antibody in a subset of breast carcinomas, but the majority displayed a luminal staining pattern. This mixed phenotype provided the first evidence for multilineage evolution within the tumor (Dairkee et al 1985). Based on genome-wide gene expression profiling of breast tumors, we now know that these carcinomas belong to the basal-like subtype of breast cancers, which are assumed to be stem cell-derived or to have acquired properties of stem cells during transformation (Sørlie et al 2001).…”
Section: Cytokeratin Staining Patterns In Normal and Neoplastic Breasmentioning
confidence: 99%
“…In head and neck squamous cell carcinomas, the p63 locus is often amplified, suggesting an oncogenic role (23). However, in other types of tumors, basal epithelial markers like p63 and keratin 14 are lost (24)(25)(26), and ΔNp63 has been found to suppress EMT in prostate and bladder cancer cells (27,28). Surprisingly, in one report, ΔNp63α and ΔNp63β were found to inhibit, whereas ΔNp63γ promoted, EMT in MCF10A mammary epithelial cells (29).…”
mentioning
confidence: 99%
“…Moreover, loss of keratin 14-positive cells in transplantable sublines of mouse mammary carcinoma has been recently reported by the authors to be accompanied by the acquisition of lung-colonizing capability and patchy type IV collagen surrounding cancer nests (10). Keratin 14 has been thought to be identified only in cryostat sections (3,11,17), but it can now be seen in methacarn-fixed, dewaxed and actinasepretreated sections. In this paper, correlations among the immunolocalizations of some cytokeratins, muscle actin and type IV collagen are investigated in serial sec- Table 2.…”
mentioning
confidence: 99%