Monoclonal antibody Ber‐EP4 reliably discriminates between microcystic adnexal carcinoma and basal cell carcinoma

Krahl, Dieter; Sellheyer, Klaus

doi:10.1111/j.1600-0560.2006.00710.x

Cited by 82 publications

(64 citation statements)

References 41 publications

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“…32,33 Interestingly enough, while CD10 reportedly only stains the stromal cells in squamous cell carcinoma, we noted CD10 expression in the lesional cells in two cases (25%). 32 A more recent study by Krahl et al 26 indicates absence of BerEP4, a monoclonal antibody recognizing two glycopolypeptides (34 and 39 kDa) found in most human epithelial cells, in all c(13/13) cases of microcystic adnexal carcinoma, and presence in all (28/28) cases of infiltrative basal cell carcinoma, thus attesting to its utility in separating microcystic adnexal carcinoma from infiltrative basal cell carcinoma. 34 The utility of this antibody in distinguishing basal cell carcinoma and squamous cell carcinoma based upon its consistent expression in the former and absence in the latter is well documented.…”

Section: Discussionmentioning

confidence: 97%

“…However, studies investigating the utility of immunohistochemistry in the diagnosis of microcystic adnexal carcinoma are few and restricted both in the spectrum of lesions and antibodies studied (Table 1). [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] Thus, even though immunohistochemical comparisons of microcystic adnexal carcinoma vs infiltrative basal cell carcinoma and desmoplastic trichoepithelioma exist in the published literature, they are confined to a single stain; and to date, only two studies employing a panel of immunohistochemical stains are performed. 17,19,21,23,24,26 In addition, a comparative study of microcystic adnexal carcinoma with squamous cell carcinoma particularly squamous cell carcinoma with ductal differentiation has not, to our knowledge, been reported previously.…”

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confidence: 99%

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Microcystic adnexal carcinoma: an immunohistochemical reappraisal

Hoang

Dresser

Kapur³

et al. 2008

Modern Pathology

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Even though immunohistochemical comparisons of microcystic adnexal carcinoma vs infiltrative basal cell carcinoma and desmoplastic trichoepithelioma exist, they are mostly restricted to the use of a single stain. In addition, a comparison with squamous cell carcinoma has not been reported previously. In this study, we compare the expression of cytokeratin (CK) 15, CK7, CK20, CK903, carcinoembryonic antigen (CEA), CD10, CD15 and BerEP4 in 13 microcystic adnexal carcinoma, eight desmoplastic trichoepithelioma, 10 infiltrative basal cell carcinoma, and eight squamous cell carcinoma of which five exhibited ductal differentiation. We found that the majority of microcystic adnexal carcinoma (92%) and desmoplastic trichoepithelioma (100%) cases expressed CK15 while the infiltrative basal cell carcinoma and squamous cell carcinoma cases were all negative. Forty percent of infiltrative basal cell carcinoma expressed CK7; while only two microcystic adnexal carcinoma cases (15%) and one squamous cell carcinoma with ductal differentiation (12%) expressed CK7 in the remaining three tumor categories. None of the desmoplastic trichoepithelioma expressed CK7. All tumors were strongly positive for CK903. While the neoplastic cells were negative, luminal staining of ductal structures was noted for CK7, CD15 and CEA in some of the microcystic adnexal carcinoma, desmoplastic trichoepithelioma and squamous cell carcinoma with ductal differentiation cases. Sixty percent of infiltrative basal cell carcinoma, 31% of microcystic adnexal carcinoma, and 25% of squamous cell carcinoma express CD10. BerEP4 expression was noted in 38% of microcystic adnexal carcinoma, 57% of desmoplastic trichoepithelioma, 100% of infiltrative basal cell carcinoma, and 38% of squamous cell carcinoma. In conclusion, we found CK15 to be a useful marker in distinguishing microcystic adnexal carcinoma from infiltrative basal cell carcinoma and squamous cell carcinoma with ductal differentiation. Our experience indicates that microcystic adnexal carcinoma and desmoplastic trichoepithelioma have a similar immunohistochemical profile that is, CK15 þ and BerEP4 þ /À; thus, additional studies are needed to separate these two entities.

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Section: Discussionmentioning

confidence: 97%

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confidence: 99%

Microcystic adnexal carcinoma: an immunohistochemical reappraisal

Hoang

Dresser

Kapur³

et al. 2008

Modern Pathology

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“…86,90 In addition, CK15 stains positive in MAC and is negative in mBCC. 86,90 Reports are mixed regarding whether a subset of MACs may express Ber-Ep4, 53,91,92 and MACs may express p75NTR. 71 …”

Section: Microcystic Adnexal Carcinomamentioning

confidence: 99%

Histologic Mimics of Basal Cell Carcinoma

Stanoszek

Wang

Harms

2017

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Thus, misdiagnosis has significant potential to result in overtreatment or undertreatment. Objective.— To review key features distinguishing BCC from histologic mimics, including current evidence regarding immunohistochemical markers useful for that distinction. Data Sources.— Review of pertinent literature on BCC immunohistochemistry and differential diagnosis. Conclusions.— In most cases, BCC can be reliably diagnosed by histopathologic features. Immunohistochemistry may provide useful ancillary data in certain cases. Awareness of potential mimics is critical to avoid misdiagnosis and resulting inappropriate management.

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“…The nasopharyx is lined by nonkeratinizing squamous and respiratory-type mucosa that does not closely resemble the skin, although seromucinous glands can be found in the posterior pharynx. Ultimately, even in the absence of perfect homology across anatomic locales, the existence of a mucosal head and neck tumor which is analogous to MAC can likely be explained by a multipotent stem cell capable of a variety of lines of differentiation [15]. However, because adnexal structures do not reside in the mucosal head and neck, we prefer the term sclerosing microcystic adenocarcinoma for the tumors arising in these mucosal locales.…”

Section: Casementioning

confidence: 99%

Sclerosing Microcystic Adenocarcinoma of the Head and Neck Mucosa: A Neoplasm Closely Resembling Microcystic Adnexal Carcinoma

Mills

Policarpio-Nicholas

Agaimy

et al. 2016

Head and Neck Pathol

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Microcystic adnexal carcinoma (MAC) occurs predominantly in the centrofacial skin and has been only rarely reported in mucosal surfaces. We here present a 5 case series of tumors closely resembling MAC occurring in the mucosal surfaces of the head and neck, which we have termed sclerosing microcystic adenocarcinomas. These tumors showed a predilection for women (4:1) with an average patient age of 52.6 years (range 41-73 years). Location included the tongue (n = 2), the floor of the mouth (n = 2), and the nasopharynx/clivus (n = 1). One occurred after radiation therapy and another occurred in the setting of immune compromise. Immunohistochemistry highlighted a dual cell population with luminal cells showing positivity for high and low-molecular weight keratins and surrounding myoepithelial cells showing S100 and smooth muscle actin staining. No cases had nodal involvement, and the single patient with clinical follow-up was alive and free of disease 34 months after diagnosis and definitive radiochemotherapy. Differential diagnoses for all cases diverged from those provoked by MAC in the skin and included a variety of salivary gland neoplasms such as adenoid cystic carcinoma, polymorphous low grade adenocarcinoma, and mucoepidermoid carcinoma. Recognition of sclerosing microcystic adenocarcinoma in the head and neck mucosa is critical given its bland appearance and subtle infiltration pattern, infrequency of nodal involvement, and behavioral differences from the other entities on the differential.Keywords Sclerosing microcystic adnexal carcinoma Á Microcystic adnexal carcinoma Á MAC Á Head and neck Á Salivary gland carcinoma Á Mucosal

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Monoclonal antibody Ber‐EP4 reliably discriminates between microcystic adnexal carcinoma and basal cell carcinoma

Cited by 82 publications

References 41 publications

Microcystic adnexal carcinoma: an immunohistochemical reappraisal

Microcystic adnexal carcinoma: an immunohistochemical reappraisal

Histologic Mimics of Basal Cell Carcinoma

Sclerosing Microcystic Adenocarcinoma of the Head and Neck Mucosa: A Neoplasm Closely Resembling Microcystic Adnexal Carcinoma

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