Monoclonal Antibodies Targeting Ion Channels and Their Therapeutic Potential

Haustrate, Aurélien; Hantute-Ghesquier, Aline; Prevarskaya, Natalia; Lehen’kyi, V’yacheslav

doi:10.3389/fphar.2019.00606

Cited by 24 publications

(22 citation statements)

References 88 publications

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“…Moreover, TRP channels could be potential candidates for therapeutic targets, especially since they are usually expressed on the cell surface, which makes them accessible to small-molecule inhibitors and biological molecules, such as monoclonal antibodies and fusion proteins [158][159][160]. Given the fact that some TRP channels are ubiquitously expressed, the delivery of TRP channel inhibitors to the tumor sites could be supported by cancer cell-specific drug delivery systems that are currently being developed [161].…”

Section: Discussionmentioning

confidence: 99%

TRP Channels in Digestive Tract Cancers

Stokłosa

Borgström

Kappel

et al. 2020

IJMS

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Cancers of the digestive tract are among the most prevalent types of cancer. These types of cancers are often diagnosed at a late stage, which results in a poor prognosis. Currently, many biomedical studies focus on the role of ion channels, in particular transient receptor potential (TRP) channels, in cancer pathophysiology. TRP channels show mostly non-selective permeability to monovalent and divalent cations. TRP channels are often dysregulated in digestive tract cancers, which can result in alterations of cancer hallmark functions, such as enhanced proliferation, migration, invasion and the inability to induce apoptosis. Therefore, TRP channels could serve as potential diagnostic biomarkers. Moreover, TRP channels are mostly expressed on the cell surface and ion channel targeting drugs do not need to enter the cell, making them attractive candidate drug targets. In this review, we summarize the current knowledge about TRP channels in connection to digestive tract cancers (oral cancer, esophageal cancer, liver cancer, pancreatic cancer, gastric cancer and colorectal cancer) and give an outlook on the potential of TRP channels as cancer biomarkers or therapeutic targets.

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Section: Discussionmentioning

confidence: 99%

TRP Channels in Digestive Tract Cancers

Stokłosa

Borgström

Kappel

et al. 2020

IJMS

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“…This means that these drugs are not subjected to efflux pumps, bypassing this major chemoresistance mechanism. Membrane localization is also an invaluable opportunity for the use of selective monoclonal antibodies [208].…”

Section: Concluding Remarks and Perspectivesmentioning

confidence: 99%

Emerging Roles for Ion Channels in Ovarian Cancer: Pathomechanisms and Pharmacological Treatment

Altamura

Greco

Carratù

et al. 2021

Cancers

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Ovarian cancer (OC) is the deadliest gynecologic cancer, due to late diagnosis, development of platinum resistance, and inadequate alternative therapy. It has been demonstrated that membrane ion channels play important roles in cancer processes, including cell proliferation, apoptosis, motility, and invasion. Here, we review the contribution of ion channels in the development and progression of OC, evaluating their potential in clinical management. Increased expression of voltage-gated and epithelial sodium channels has been detected in OC cells and tissues and shown to be involved in cancer proliferation and invasion. Potassium and calcium channels have been found to play a critical role in the control of cell cycle and in the resistance to apoptosis, promoting tumor growth and recurrence. Overexpression of chloride and transient receptor potential channels was found both in vitro and in vivo, supporting their contribution to OC. Furthermore, ion channels have been shown to influence the sensitivity of OC cells to neoplastic drugs, suggesting a critical role in chemotherapy resistance. The study of ion channels expression and function in OC can improve our understanding of pathophysiology and pave the way for identifying ion channels as potential targets for tumor diagnosis and treatment.

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“…The following section will focus biological treatments that specifically target ion channels and nociception in peripheral nerves. Monoclonal antibodies (mAbs) represent a rapidly growing class of biological drugs [55]. Whether mAbs injected locally or delivered orally and systemically, they are becoming an important arsenal in precision medicine and targeted cancer therapy [56][57][58].…”

Section: Emerging Biological Treatments For Oamentioning

confidence: 99%

“…Whether mAbs injected locally or delivered orally and systemically, they are becoming an important arsenal in precision medicine and targeted cancer therapy [56][57][58]. Many of the recently developed mAbs are characterized by their high specificity and affinity for the target antigen, which is often present on the cell surface [55]. This is why it is crucially important to learn more about the surfaceome and membranome of chondrocytes and other cell types within the synovial joint, which has been an active area of research in our laboratory for the last few years [59,60].…”

Section: Emerging Biological Treatments For Oamentioning

confidence: 99%

Neuroscience and Neuroimmunology Solutions for Osteoarthritis Pain: Biological Drugs, Growth Factors, Peptides and Monoclonal Antibodies Targeting Peripheral Nerves

Mobasheri¹

2020

Preprint

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Neuroscience is a vast discipline that deals with the anatomy, biochemistry, molecular biology, physiology and pathophysiology of central and peripheral nerves. Advances made through basic, translational, and clinical research in the field of neuroscience have great potential for long-lasting and beneficial impacts on human health. The emerging field of biological therapy is intersecting with the disciplines of neuroscience and rheumatology, creating new horizons for interdisciplinary and applied research. Biological drugs, growth factors, neuropeptides and monoclonal antibodies are being developed and tested for the treatment of painful arthritic and rheumatic diseases. This concise communication focuses on the solutions provided by the fields of neuroscience and neuroimmunology for real-world clinical problems in the field of rheumatology, focusing on synovial joint pain and the emerging biological treatments that specifically target pathways implicated in osteoarthritis pain in peripheral nerves.

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Monoclonal Antibodies Targeting Ion Channels and Their Therapeutic Potential

Cited by 24 publications

References 88 publications

TRP Channels in Digestive Tract Cancers

TRP Channels in Digestive Tract Cancers

Emerging Roles for Ion Channels in Ovarian Cancer: Pathomechanisms and Pharmacological Treatment

Neuroscience and Neuroimmunology Solutions for Osteoarthritis Pain: Biological Drugs, Growth Factors, Peptides and Monoclonal Antibodies Targeting Peripheral Nerves

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