Monoclonal Antibodies against <i>Helicobacter pylori</i> Cross‐React with Human Tissue

Ko, Gyung Hyuck; Park, Heung Bae; Shin, Myoung Keun; Park, Cheol Keun; Lee, Jeong-Hee; Youn, Hee Shang; Cho, Myung Je; Lee, Woo Kon; Rhee, Kwang Ho

doi:10.1111/j.1523-5378.1997.tb00090.x

Cited by 53 publications

(35 citation statements)

References 20 publications

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“…Some H. pylori infected patients have an autoantibody response [36,37]. According to the data of Appelmelk et al [38] and Ko et al [39], H. pylori infection may be implicated in extra-digestive diseases and particularly in autoimmune response against epithelial cells of various organs. Antigenic mimicry is a hypothetical mechanism explaining the cross-reaction between antigens of H. pylori and cells of various host tissues such as kidney tubular cells, ductal cells of the salivary glands, follicles of the thyroid gland, etc.…”

Section: Resultsmentioning

confidence: 99%

Association between Helicobacter pylori infection and the presence of anti-sperm antibodies

Dimitrova-Dikanarova

Lazarov

Tafradjiiska-Hadjiolova

et al. 2016

Biotechnology & Biotechnological Equipment

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The aim of this study was to investigate the possible association between serum anti-Helicobacter pylori antibodies and anti-sperm antibodies (ASA) in patients with gastroduodenal diseases caused by H. pylori, infertile patients positive for ASA and healthy fertile blood donors as controls. Serum ASA were studied by sperm agglutination tests, sperm immobilization test and ELISA against sperm antigens (ELISAsp). Serum IgG anti-H. pylori antibodies were detected by ELISA (ELISAHp). The tests revealed significantly higher incidence of ASA in patients with gastroduodenal diseases compared to the controls (P < 0.0001). The median levels of both types of antibodies were significantly higher in infertile patients than in patients with upper gastroduodenal diseases in all tests applied (sperm agglutination and immobilization tests P < 0.0001; ELISAsp P D 0.006; ELISAHp, P D 0.0008). Significant linear correlation was found between anti-H. pylori antibodies and ASA detected by sperm immobilization test (r D 0.613, P D 0.05) in the group of patients with gastroduodenal disease, as well as a weak linear correlation was established between anti-H. pylori antibodies and ASA in ELISAsp (r D 0.275, P D 0.0051) in the same group. These results suggest that H. pylori infection may play a role in the induction of ASA.

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Section: Resultsmentioning

confidence: 99%

Association between Helicobacter pylori infection and the presence of anti-sperm antibodies

Dimitrova-Dikanarova

Lazarov

Tafradjiiska-Hadjiolova

et al. 2016

Biotechnology & Biotechnological Equipment

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“…It has been demonstrated that antibodies against H. pylori may also react with some extra-gastric tissues, such as glomerular capillary walls, ductal cells of the salivary glands and renal tubular cells (Ko et al, 1997), but there is no proof of cross-reactivity between platelet antigen and the bacterium at present.…”

Section: Discussionmentioning

confidence: 99%

Effect of Helicobacter pylori eradication on platelet recovery in Japanese patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura

et al. 2002

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Summary. The prevalence of Helicobacter pylori infection and the effect of its eradication on platelet count in 48 Japanese patients with autoimmune thrombocytopenic purpura (AITP), including 40 chronic idiopathic thrombocytopenic purpura (ITP) and eight secondary AITP, were investigated. H. pylori infection was found in 25 ITP patients (62AE5%) and in two secondary AITP (25%). H. pylori eradication was obtained in 19 of 19 infected ITP patients (100%), who were not in remission (platelets < 100 · 10 9 /l) at the time of infection assessment. During follow-up (median 14AE8 months), 12 of 19 H. pylori-eradicated patients (63AE2%) showed a significant increase in platelet count accompanied by a significant decrease of plateletassociated immunoglobulin G (IgG). This response was maintained in all responding patients throughout the follow-up period. However, two infected patients with secondary AITP did not show platelet increase after eradication. The assessment of H. pylori infection and its eradication should be attempted in ITP as this approach could be an effective strategy, at least for some of these patients.

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“…The pathogenic mechanism underlying this relationship is still to be clarified. However, it has been demonstrated that antibodies against H. pylori also react with some extragastric tissues [4], so that molecular mimicry could be responsible for autoimmunity in infected patients [5,6].…”

Section: Introductionmentioning

confidence: 99%

Platelet response to Helicobacter pylori eradication therapy in adult chronic idiopathic thrombocytopenic purpura seems to be related to the presence of anticytotoxin-associated gene A antibodies

Scandellari

Allemand

Vettore

et al. 2009

Blood Coagulation &Amp; Fibrinolysis

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The aims of this study were to assess the prevalence of Helicobacter pylori infection in chronic idiopathic thrombocytopenic purpura adult patients and investigate the platelet response after eradication. To minimize the confounding effect of concomitant idiopathic thrombocytopenic purpura therapies, patients were eligible for the prospective study if they had 20-100 x 10/l platelets, and no requirement for treatment for thrombocytopenia or no change of doses of ongoing medications for at 3 months before inclusion.Helicobacter pylori infection was assessed in 62 patients using a stool antigen test, and the infection was present in 52% of patients. Immunoglobulin G antibodies against the cytotoxin-associated gene A protein were detected in 53% of infected patients. All patients underwent sampling for specific platelet autoantibodies, 37.5% of H. pylori-positive and 33% of H. pylori-negative patients had detectable platelet autoantibodies. Sixteen eligible H. pylori-positive patients were submitted to the eradication therapy and followed in the prospective study. We considered 14 H. pylori-negative patients as control group. Platelet response was defined as an incremental increase above 50% from baseline platelet count. A positive response was observed in 43% patients after 6 months of follow-up. Eradicated responder and nonresponder patients were comparable for all main clinical features but not for anticytotoxin-associated gene A antibodies (83 vs. 12.5%, P = 0.026).Given the good cost-benefit ratio, we believe that all idiopathic thrombocytopenic purpura patients should be screened for H. pylori infection and eradication treatment should be considered, particularly for patients who are also found positive for anticytotoxin-associated gene A antibodies.

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Monoclonal Antibodies against Helicobacter pylori Cross‐React with Human Tissue

Abstract: It is believed that the autoimmune reaction might be involved in the pathogenesis of chronic gastritis due to H. pylori infection, and that the autoimmune reaction induced by H. pylori infection might also be involved in the pathogenesis of various diseases in other organs.

Cited by 53 publications

References 20 publications

Association between Helicobacter pylori infection and the presence of anti-sperm antibodies

Association between Helicobacter pylori infection and the presence of anti-sperm antibodies

Effect of Helicobacter pylori eradication on platelet recovery in Japanese patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura

Platelet response to Helicobacter pylori eradication therapy in adult chronic idiopathic thrombocytopenic purpura seems to be related to the presence of anticytotoxin-associated gene A antibodies

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