Monoclonal Antibodies against Human Milkfat Globule Membranes Useful in Carcinoma Research

Immunohistochemical expression of monoclonal antibody against epithelial membrane antigen in salivary gland tumors.

“…Recently several types of monoclonal antibodies to EMA have been used by the immunoperoxidase technique in normal and pathologic tissues and organs including neoplastic lesions. In the distribution profiles of the antigens, the differences are noted even within the same tissue (5,6,10,11,29). However, several types of mouse monoclonal antibodies (E29 and HMFG-2)) were bound in the same areas in tissue sections (9).…”

Serum CA 15-3 assay in the diagnosis and follow-up of breast cancer

“…A radioimmunometric assay based on two different monoclonal antibodies (115 D8 and DF3) has been introduced for a breast cancer-associated antigen CA 15-3 (Kufe et al, 1984;Hilkens et al, 1984). Preliminary clinical evidence indicates that in the follow-up of breast cancer CA 15-3 is more sensitive than CEA (Hayes et al, 1986;Wurz et al, 1986;Pons-Anicet et al, 1987).…”

Human Epithelial Related Antigen (hERA) in Salivary Glands and Their Tumors: Immunohistochemical Observations.

“…The monoclonal antibodies against MAM-3 and MAM-6 antigen, each specific for a different epitope determinant, have been investigated in mammary glands and their tumors [3,4], endometrial and endocervixia and their tumors [15] and skin adnexia and their tumors [16]. MAM-6 antigen recognized by monoclonal 115D8 antibody is seen in luminal and lateral borders of serous acinar cells in the normal gland.…”