Monoaminergic Multilocus Genetic Variants Interact with Stressful Life Events in Predicting Changes in Adolescent Anxiety Symptoms: A One-year Longitudinal Study

Cao, Cong; Sun, Kexin; Cao, Lili; Li, Feifei

doi:10.1007/s10964-021-01496-y

Cited by 4 publications

(3 citation statements)

References 48 publications

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“…Anxiety disorders are considered to be highly polygenic. The degree of gene expression is associated with the severity of the anxiety disorder, especially genes relevant to monoaminergic neurotransmission or stress axis function 144,145 . DNA methylation, histone modification, and noncoding RNA regulation play important roles in epigenetic mechanisms of anxiety disorders 146,147 .…”

Section: The Pathogenesis Of Anxietymentioning

confidence: 99%

“…The degree of gene expression is associated with the severity of the anxiety disorder, especially genes relevant to monoaminergic neurotransmission or stress axis function. 144 , 145 DNA methylation, histone modification, and noncoding RNA regulation play important roles in epigenetic mechanisms of anxiety disorders. 146 , 147 Unlike DNA sequence changes, the processes involved in the regulation of gene transcription and expression are reversible.…”

Section: The Pathogenesis Of Anxietymentioning

confidence: 99%

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Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms

Zhao,

Zhou,

Liu

et al. 2023

Anim Models and Exp Med

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Anxiety disorders have become one of the most severe psychiatric disorders, and the incidence is increasing every year. They impose an extraordinary personal and socioeconomic burden. Anxiety disorders are influenced by multiple complex and interacting genetic, psychological, social, and environmental factors, which contribute to disruption or imbalance in homeostasis and eventually cause pathologic anxiety. The selection of a suitable animal model is important for the exploration of disease etiology and pathophysiology, and the development of new drugs. Therefore, a more comprehensive understanding of the advantages and limitations of existing animal models of anxiety disorders is helpful to further study the underlying pathological mechanisms of the disease. This review summarizes animal models and the pathogenesis of anxiety disorders, and discusses the current research status to provide insights for further study of anxiety disorders.

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Section: The Pathogenesis Of Anxietymentioning

confidence: 99%

Section: The Pathogenesis Of Anxietymentioning

confidence: 99%

Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms

Zhao,

Zhou,

Liu

et al. 2023

Anim Models and Exp Med

View full text Add to dashboard Cite

show abstract

“…In parallel, the vast majority of reward-related Polygene × Environment interaction research has provided indirect evidence supporting that heightened RR may work as a plasticity factor. For instance, research indicates that individuals with high dopaminergic genetic composite scores are susceptible to both poor and supportive environments, exhibiting more and fewer psychiatric symptoms, including depression, anxiety, and aggressive behaviors (Cao et al, 2021; Davies et al, 2019; Stocker et al, 2017). Notably, many studies of differential susceptibility support a “domain general” susceptibility with respect to both development “inputs” (e.g., different stress types) and/or “outputs” (e.g., depression, aggression, cognition; Belsky & Pluess, 2009; Ellis et al, 2011).…”

mentioning

confidence: 99%

Heightened neural reward responsiveness functions as a plasticity factor moderating the association between childhood emotional abuse and young adult depressive symptoms: Evidence of differential susceptibility.

Yang,

Xu,

Cao

2024

Journal of Psychopathology and Clinical Science

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As a neural indicator of reward responsiveness (RR), reward positivity (RewP) has been demonstrated to moderate the association between stress exposure and depressive symptoms. However, extant research has primarily (a) focused on life stress rather than early maltreatment, (b) ignored the time-frequency components, and (c) has been based on a traditional perspective of diathesis stress. The present study aimed to comprehensively examine whether and how neurophysiological (RewP and its time-frequency decomposition components) and self-reported measures of RR interact with childhood emotional abuse on young adult depressive symptoms. The sample of 192 Chinese university students aged 18-25 (M age = 21.08 + 1.91 years; 59.4% girls) completed self-reported questionnaires of emotional abuse, depressive symptoms and RR. The RewP and its time-frequency components delta and theta were elicited via a monetary reward task. The results demonstrated that RewP significantly moderated the association between emotional abuse and young adult depressive symptoms in a differential susceptibility but not diathesis-stress manner. However, gain-related delta, loss-related theta, or self-reported RR did not drive such moderation effects. These findings were robust and survived a series of rigorous sensitivity analyses. The current findings provide preliminary evidence that heightened RewP may function as a plasticity factor moderating the association between early maltreatment exposure and depression, and highlight the effect specific to emotional abuse. However, caution should be paid to the generalizability of these findings in high-risk clinical samples, in light of the current highfunctioning sample features and low rates of high symptom and abuse levels. General Scientific SummaryReward positivity (RewP) has been identified as a reliable neuromarker of reward responsiveness and plays a key role in the pathology of depression. This study suggests that heightened RewP may be a plasticity factor and moderate the association between emotional abuse and young adult depressive symptoms in a differential susceptibility manner.

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Hypothalamic-pituitary-adrenal Axis Multilocus Genetic Variation, Childhood Parenting and Adolescent Anxiety Symptoms: Evidence of Cumulative Polygenic Plasticity

Cao

Yang

Sun

et al. 2022

J Youth Adolescence

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Monoaminergic Multilocus Genetic Variants Interact with Stressful Life Events in Predicting Changes in Adolescent Anxiety Symptoms: A One-year Longitudinal Study

Cited by 4 publications

References 48 publications

Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms

Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms

Heightened neural reward responsiveness functions as a plasticity factor moderating the association between childhood emotional abuse and young adult depressive symptoms: Evidence of differential susceptibility.

Hypothalamic-pituitary-adrenal Axis Multilocus Genetic Variation, Childhood Parenting and Adolescent Anxiety Symptoms: Evidence of Cumulative Polygenic Plasticity

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