Monoamine system disruption induces functional somatic syndromes associated symptomatology in mice

Nagakura, Yukinori; Ohsaka, Nana; Azuma, Ryutarou; Takahashi, Saeri; Takebayashi, Yuuka; Kawasaki, Saori; Murai, Shuhei; Miwa, Masaya; Saito, Hiroko

doi:10.1016/j.physbeh.2018.07.007

Cited by 17 publications

(11 citation statements)

References 64 publications

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“…After the mice became stationary, the body weight was recorded from the digital display of the weighing scale once it had stabilized. Body weight was measured for up to six days after the third reserpine injection (n = 6) [31].…”

Section: Body Weightmentioning

confidence: 99%

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Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model

et al. 2020

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Background Fibromyalgia patients experience cardiovascular complications in addition to musculoskeletal pain. This study aimed to investigate the cardiac effects of a prolonged shallow water gait in a fibromyalgia-induced young mouse model. Methods To produce a fibromyalgia mouse model, wild-type mice were administered an intraperitoneal injection of reserpine once a day for three days, and two primary experiments were performed. First, three types of gait tests were performed before and after the reserpine injections as follows: (i) 5 minutes of free gait outside the water, (ii) 1 minute of free gait in shallow warm water, and (iii) 5 minutes of free gait in shallow warm water. Second, electrocardiogram recordings were taken before and after the three gait tests. The average heart rate and heart rate irregularity scores were analyzed. Results Exercise-induced cardiac arrhythmia was observed at 1-minute gait in shallow water during the acute stage of induced FM in young mice. Further, both cardiac arrhythmia and a decrease in HR have occurred at 5-minute gait in shallow water at the same mice. However, this phenomenon was not observed in the wild-type mice under any test conditions. Conclusion Although a short-term free gait in shallow warm water may be advantageous for increasing the motor activity of FM-model mice, we should be aware of the risk of prolonged and excessive exercise-induced cardiac arrhythmia. For gait exercises in shallow water as a treatment in FM patients. We suggest a gradual increase in exercise duration may be warranted.

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Section: Body Weightmentioning

confidence: 99%

“…The temperature-sensitive probe was connected to equipment that indicated a digital temperature scale. Rectal temperatures were taken for six days after inducing FM in the model mice (n = 6) [31].…”

Section: Rectal Temperaturementioning

confidence: 99%

Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model

et al. 2020

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“…A previous study reported that the metabolites of serotonin, dopamine, and noradrenaline in the cerebrospinal fluid (CSF) were lower in patients with FM, suggesting that catecholamine levels may be lower in the brain (47). Consistently, the animal model of FM with repeated reserpine administration replicated human FM symptoms and displayed decreases in catecholamines in the brain and spinal cord (29,34,35,48,49). The present study also replicated characteristic symptoms of human patients with FM and the animal model of FM reported in previous studies.…”

Section: Reproduction Of the Fm Modelmentioning

confidence: 74%

“…First, patients with FM often present with eating disorders and/or bodyweight loss (50,51). Previous animal studies also reported that the FM mouse model displayed the lowest bodyweight 3 days after the first injection (31,48). After the reserpine administration, access to food was reduced, eating time was extended, and food intake was sharply reduced (52).…”

Section: Reproduction Of the Fm Modelmentioning

confidence: 99%

Involvement of Parvalbumin-Positive Neurons in the Development of Hyperalgesia in a Mouse Model of Fibromyalgia

et al. 2021

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Fibromyalgia (FM) presents as chronic systemic pain, which might be ascribed to central sensitization, in which pain information processing is amplified in the central nervous system. Since patients with FM display elevated gamma oscillations in the pain matrix and parvalbumin (PV)-positive neurons play a critical role in induction of gamma oscillations, we hypothesized that changes in PV-positive neurons are involved in hyperalgesia in fibromyalgia. In the present study, to investigate a role of PV-positive neurons in neuropathic pain, mice received reserpine administration for 3 consecutive days as an animal model of FM (RES group), while control mice received vehicle injections in the same way (VEH group). The mice were subjected to hot-plate and forced swim tests, and immuno-stained PV-positive neurons were counted in the pain matrix. We investigated relationships between PV-positive neuron density in the pain matrix and pain avoidance behaviors. The results indicated that the mice in the RES group showed transient bodyweight loss and longer immobility time in the forced swim test than the mice in the VEH group. In the hot-plate test, the RES group showed shorter response latencies and a larger number of jumps in response to nociceptive thermal stimulus than the VEH group. Histological examination indicated an increase in the density of PV-positive neurons in the primary somatosensory cortex (S1) in the RES group. Furthermore, response latencies to the hot-plate were significantly and negatively correlated with the density of PV-positive neurons in the S1. These results suggest a critical role for PV-positive neurons in the S1 to develop hyperalgesia in FM.

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“…In the case of mice, there is a range of protocols used. Reserpine is preferably administered subcutaneously 12 at 0.25 (de Souza et al, 2014;Peres Klein et al, 2016;Nagakura et al, 2018), 0.5 (Kaur et al, 2021;Schossler Garcia et al, 2021a), or 1 mg/kg (Xu et al, 2013;Liu et al, 2014;Brum et al, 2020) once daily for three consecutive days. Intraperitoneal administration at 0.5 mg/kg once daily for three consecutive days is also employed (Sousa et al, 2018).…”

Section: Protocol For Rim-induced Nociplastic Pain-associated Phenotypesmentioning

confidence: 99%

Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model

Nagakura

2022

J Pharmacol Exp Ther

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ABBREVIATIONS: AMPA, α-3-hydroxy-5-methyl-4-isoxazole propionic acid; ASIC, acid-sensing ion channel; ATP, adenosine triphosphate; AT -RvD1, aspirin-triggered resolvin D1; AT -RvD2, aspirin-triggered resolvin D2; BBG, brilliant blue G; 2-BFI, 2-(2-Benzofuranyl)-2-imidazoline; CaMKII, calmodulin-dependent protein kinase II; CAT, catalase; CNS, central nervous system; CoQ10, coenzyme Q10; CSF, cerebrospinal fluid; Cox, cyclooxygenase; DA, dopamine; DALBk, des-Arg 9 -[Leu 8 ]bradykinin; DRG, dorsal root of ganglia; EEG, electroencephalography; EPM, elevated plus maze; EZM, elevated zero maze; FM, fibromyalgia; FST, forced swimming test; GSH, glutathione; 5-HT, 5-hydroxytryptamine (serotonin); FAAH, fatty acid amide hydrolase; GABA, γ-aminobutyric acid; GluN2B, NMDA-type glutamate receptor subunit 2B; 11β-HA, hyperalgesia; HS, hypersensitivity; HSD, 11β-hydroxysteroid dehydrogenase; IASP, the International Association for the Study of Pain; IL, interleukin; iNOS, inducible nitric oxide synthase; KCC2, K + -Clco-transporter 2; LA, locomotor activity; LPO, lipid peroxide; MA, mechanical allodynia; MAO, monoamine oxidase; (m-CF3-PhSe) 2 , m-trifluoromethyl-diphenyl diselenide; MDA, malondialdehyde; Mfn, mitofusin; MWM, Morris water maze; NA, noradrenaline; Nav, voltage-dependent Na + channel; NF-κB, nuclear factor-κB; NGF, nerve growth factor; NLRP, nucleotide-binding oligomerization domain (NOD)-like receptor protein;

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Monoamine system disruption induces functional somatic syndromes associated symptomatology in mice

Cited by 17 publications

References 64 publications

Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model

Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model

Involvement of Parvalbumin-Positive Neurons in the Development of Hyperalgesia in a Mouse Model of Fibromyalgia

Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model

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