“…Studies utilizing such compounds have revealed an important modulatory role for 5-HT on the behavioral effects of cocaine. For example, indirect 5-HT agonists such as SERT inhibitors or 5-HT releasers have been found to attenuate the behavioral-stimulant effects (Spealman, 1993;Howell and Byrd, 1995), reinforcing effects (Kleven and Woolverton, 1993;Glowa et al, 1997;Czoty et al, 2002;Negus et al, 2007), and reinstatement effects (Ruedi-Bettschen et al, 2010;Howell and Negus, 2014) of cocaine in nonhuman primates. Interestingly, some SERT inhibitors (e.g., fluoxetine, citalopram), which evoked saline-responding when administered alone, enhanced the discriminative stimulus effects of cocaine in both monkeys (Spealman, 1993;Schama et al, 1997) and rats (Cunningham and Callahan, 1991;Callahan and Cunningham, 1997).…”