Monoamine oxidase type a: differences in selectivity towards l-norepinephrine compared to serotonin

MDMA (Ecstasy) Inhibition of MAO Type A and Type B: Comparisons with Fenfluramine and Fluoxetine (Prozac)

“…Monoamine oxidase A is an enzyme whose preferred substrate is serotonin (Garrick and Murphy 1982) and is localized in dopaminergic neurons (West lund et al 1985). Serotonin has recently been reported to promote the release of DA through the dopamine transporter by an exchange-diffusion mechanism (Ja cocks and Cox 1992).…”

“…[Neuropsychopharmacology 10: [231][232][233][234][235][236][237][238]1994] for serotonin is 1170 IlmollL (Fowler and Tipton 1982;Garrick and Murphy 1982). Monoamine oxidase A is inhibited by nanomolar concentrations of clorgyline (Johnston 1968).…”

“…Monoamine oxidase A is inhibited by nanomolar concentrations of clorgyline (Johnston 1968). Monoamine oxidase B (MAO-B) has a higher affinity for phenethylamine than MAO-A and is inhibited by nanomolar concentrations of deprenyl (Garrick and Murphy 1982;Yang and Neff 1974). Dopa mine (DA) is metabolized with equal affinity by both subtypes (Yang and Neff 1974).…”

The circadian rhythm of 5-HT biosynthetic and degradative enzymes in immortalized mouse neuroendocrine pineal cell line–a model for studying circadian rhythm

“…Human Placenta and fibroblasts express predominantly MAO A (Weyler and Salach, 1985;Bond and Cundall, 1977) and human platelets, lymphocytes and bovine liver express only MAO B (Donnelly and Murphy, 1977). In human placenta, both 5-HT and PEA can be oxidized by low concentration of clorgyline inhibitor (Garrick and Murphy, 1982). In bovine liver, both 5-HT and PEA can be oxidized by low concentration of deprenyl (Singer, 1979).…”

Bidirectional promoter of human monoamine oxidase A (MAO A) controlled by transcription factor Sp1

“…Furthermore, MAO A and B expression are also different during development. MAO A activity appears before MAO B activity in fetal brain (Lewinsohn et al, 1980) whereas MAO B activity is higher than MAO A in adult human brain (Garrick and Murphy, 1982).…”