Monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity in combat-related posttraumatic stress disorder

Pivac, Nela; Knežević, Jelena; Kozarić‐Kovačić, Dragica; Deželjin, Martina; Mustapić, Maja; Rak, Davor; Matijević, Tanja; Pavelić, Jasminka; Mück‐Šeler, Dorotea

doi:10.1016/j.jad.2007.01.017

Cited by 44 publications

(38 citation statements)

References 51 publications

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“…Although MDD is signifi cantly associated with the Met allele of BDNF in male subjects (Verhagen et al 2010), our results showed no signifi cant association between the BDNF polymorphism and MDD in veterans with PTSD, compared to veterans with PTSD without any comorbidity. These data are in line with the evidence that particular peripheral markers, such as concentrations of plasma cortisol, cerebrospinal fl uid corticotrophin releasing hormone, platelet serotonin, and activity of platelet monoamine oxidase and plasma dopamine beta hydroxylase, are higher in psychotic compared to non-psychotic PTSD (Sautter et al 2003;Hamner et al 2004;Pivac et al 2006Pivac et al , 2007Braakman et al 2008Braakman et al , 2009Shevlin et al 2010). We might speculate that early intervention for this more severe subtype of PTSD, complicated with psychotic features, would be treatment with atypical antypsychotics as monotherapy, or as add-on therapy with antidepressants.…”

Section: Discussionsupporting

confidence: 85%

The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder

Pivac¹,

Kozarić‐Kovačić²,

Grubišić-Ilić³

et al. 2011

The World Journal of Biological Psychiatry

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Objectives. Psychotic symptoms frequently occur in veterans with combat-related posttraumatic stress disorder (PTSD). Brain-derived neurotrophic factor (BDNF) plays a major role in neurodevelopment, neuro-regeneration, neurotransmission, learning, regulation of mood and stress responses. The Met allele of the functional polymorphism, BDNF Val66Met, is associated with psychotic disorders. This study intended to assess whether the Met allele is overrepresented in unrelated Caucasian male veterans with psychotic PTSD compared to veteran controls. Methods. The BDNF Val66Met variants were genotyped in 576 veterans: 206 veterans without PTSD and 370 veterans with PTSD subdivided into groups with or without psychotic features. Results. Veterans with psychotic PTSD were more frequently carriers of one or two Met alleles of the BDNF Val66Met polymorphism than veterans with PTSD without psychotic features and veterans without PTSD. Conclusions. The study shows that veterans with psychotic PTSD carried more Met alleles of the BDNF Val66Met than non-psychotic veterans with PTSD or veterans without PTSD. The results might add further support to the hypothesis that psychotic PTSD is a more severe subtype of PTSD.

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Section: Discussionsupporting

confidence: 85%

The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder

Pivac¹,

Kozarić‐Kovačić²,

Grubišić-Ilić³

et al. 2011

The World Journal of Biological Psychiatry

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“…Platelet monoamine oxidase activity, which generates excessive amounts of free radicals while degrading catecholamines, was also elevated in patients with PTSD (Richardson, 1993). This may bear a relation to the depletion of catecholamines that has been observed in patients with PTSD (Pivac et al, 2007). These reports support the possibility that increased levels of oxidative stress may contribute to the development of PTSD and associated cognitive dysfunction.…”

Section: Oxidative Stress In Ptsdsupporting

confidence: 53%

Common biochemical defects linkage between post-traumatic stress disorders, mild traumatic brain injury (TBI) and penetrating TBI

Prasad¹,

Bondy

2015

Brain Research

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AnxietyPsychological damage a b s t r a c t Post-traumatic stress disorder (PTSD) is a complex mental disorder with psychological and emotional components, caused by exposure to single or repeated extreme traumatic events found in war, terrorist attacks, natural or man-caused disasters, and by violent personal assaults and accidents. Mild traumatic brain injury (TBI) occurs when the brain is violently rocked back and forth within the skull following a blow to the head or neck as in contact sports, or when in close proximity to a blast pressure wave following detonation of explosives in the battlefield. Penetrating TBI occurs when an object penetrates the skull and damages the brain, and is caused by vehicle crashes, gunshot wound to the head, and exposure to solid fragments in the proximity of explosions, and other combat-related head injuries. Despite clinical studies and improved understanding of the mechanisms of cellular damage, prevention and treatment strategies for patients with PTSD and TBI remain unsatisfactory. To develop an improved plan for treating and impeding progression of PTSD and TBI, it is important to identify underlying biochemical changes that may play key role in the initiation and progression of these disorders. This review identifies three common biochemical events, namely oxidative stress, chronic inflammation and excitotoxicity that participate in the initiation and progression of these conditions. While these features are separately discussed, in many instances, they overlap. This review also addresses the goal of developing novel treatments and drug regimens, aimed at combating this triad of events common to, and underlying, injury to the brain.

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“…It has been reported that lower platelet MAO-B activity might be induced by smoking (Oreland, 2004;Pivac et al 2006aPivac et al , 2007 and chronic alcohol abuse (Oreland, 2004). To exclude the effect of smoking, all female subjects included in the study were nonsmokers.…”

Section: Discussionmentioning

confidence: 99%

“…Platelet MAO-B activity might be affected by genetic factors (Oreland 2004). Polymorphism in intron 13 of MAO-B gene does not alter platelet MAO-B activity (Jansson et al 2005;Pivac et al 2005Pivac et al , 2007.…”

Section: Discussionmentioning

confidence: 99%

Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer's disease

Mück‐Šeler

Presečki

Mímica

et al. 2009

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity in combat-related posttraumatic stress disorder

Cited by 44 publications

References 51 publications

The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder

The association between brain-derived neurotrophic factor Val66Met variants and psychotic symptoms in posttraumatic stress disorder

Common biochemical defects linkage between post-traumatic stress disorders, mild traumatic brain injury (TBI) and penetrating TBI

Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer's disease

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