Monoamine Oxidase Inhibitors: Prescription and Patient Management

Sheehan, David V.; Claycomb, J B; Kouretas, Nicholas

doi:10.2190/uvvy-h0n2-b7v1-mhw0

Cited by 46 publications

(10 citation statements)

References 30 publications

(27 reference statements)

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“…Since the half-life of phenelzine is 11.6 hours [130] as compared to 0.5–1 hour for hydralazine [131], it might provide additional neuroprotection. Though phenelzine is not a direct vasodilator, as an MAOI it can have a transient effect on blood pressure [132]. Following SCI, when hypotensive effects are particularly undesirable, phenelzine could be used as an alternative to hydralazine.…”

Section: Acrolein As a Novel Therapeutic Target For Spinal Cord Inmentioning

confidence: 99%

Acrolein‐mediated injury in nervous system trauma and diseases

Shi

Rickett

Sun

2011

Molecular Nutrition Food Res

106

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Acrolein, an α,β-unsaturated aldehyde, is a ubiquitous pollutant that is also produced endogenously through lipid peroxidation. This compound is hundreds of times more reactive than other aldehydes such as 4-hydroxynonenal, is produced at much higher concentrations, and persists in solution for much longer than better known free radicals. It has been implicated in disease states known to involve chronic oxidative stress, particularly spinal cord injury and multiple sclerosis. Acrolein may overwhelm the anti-oxidative systems of any cell by depleting glutathione reserves, preventing glutathione regeneration, and inactivating protective enzymes. On the cellular level, acrolein exposure can cause membrane damage, mitochondrial dysfunction, and myelin disruption. Such pathologies can be exacerbated by increased concentrations or duration of exposure, and can occur in normal tissue incubated with injured spinal cord, showing that acrolein can act as a diffusive agent, spreading secondary injury. Several chemical species are capable of binding and inactivating acrolein. Hydralazine in particular can reduce acrolein concentrations and inhibit acrolein-mediated pathologies in vivo. Acrolein scavenging appears to be a novel effective treatment which is primed for rapid translation to the clinic.

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Section: Acrolein As a Novel Therapeutic Target For Spinal Cord Inmentioning

confidence: 99%

Acrolein‐mediated injury in nervous system trauma and diseases

Shi

Rickett

Sun

2011

Molecular Nutrition Food Res

106

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“…It is essential that all patients on MAOIs receive dietary and drug precautions (see Tables 1, 2). 9 In our experience, elderly patients comply well and rarely complain about such restrictions. A low tyramine diet is required, necessitating avoidance of foods such as fermented cheese, yogurt, beer, red wine, and excessive amounts of caffeine and chocolate.…”

Section: Precautions and Side Effects Of Maoismentioning

confidence: 66%

The Use of Monoamine Oxidase Inhibitors in the Treatment of Elderly, Depressed Patients

Jenike¹

1984

J American Geriatrics Society

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Depression is an extremely common illness in the elderly, and is, at times, refractory to the usual therapies. The elderly are also particularly prone to develop toxic side effects from standard antidepressive agents. Monoamine oxidase inhibitors are rarely used in this population, although much evidence and clinical experience would indicate that they can be extremely effective and non-toxic. This paper outlines the indications and precautions for use and side effects of monoamine oxidase inhibitors in the treatment of depression in elderly patients.

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“…An unexpected finding was that phenelzine showed a consistent trend to be superior to imipramine. Agoraphobic patients who had been on phenelzine and imipramine at different times during the course of their treatment usually reported that they found phenelzine to be more effective than imipramine (Sheehan et al, 1980b;Sheehan, 1985). Therefore, despite the potential dangers of hypertensive crisis, MAOIs still have clinical application for the treatment of certain types of depression.…”

Section: Discussionmentioning

confidence: 99%

High levels of tyramine in some Chinese foodstuffs

Sung

Lee

Young

et al. 1986

Human Psychopharmacology

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There are many reports regarding the risk of hypertensive crisis when tyramine-containing food is taken together with monoamine oxidase inhibitors (MAOIs). Thus, psychiatric patients taking MAOIs are routinely given dietary warning cards. However, most of these cards have been prepared according to assays of tyramine in Western food samples. We now report the detection of high levels of tyramine (ranging from 0.02 to 43.0pmol/g) in some common Chinese foods, including fermented bean curd, soy sauce and fermented soya bean.

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Monoamine Oxidase Inhibitors: Prescription and Patient Management

Cited by 46 publications

References 30 publications

Acrolein‐mediated injury in nervous system trauma and diseases

Acrolein‐mediated injury in nervous system trauma and diseases

The Use of Monoamine Oxidase Inhibitors in the Treatment of Elderly, Depressed Patients

High levels of tyramine in some Chinese foodstuffs

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