Monoamine oxidase inhibitors and histamine metabolism

Benedetti, Μ. Strolin; Ancher, J. F.; Sontag, N.

doi:10.1007/bf01978589

Cited by 6 publications

(2 citation statements)

References 20 publications

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“…This is also puzzling: clorgyline enhanced first of all histamine fluorescence, however, it is a specific MAO-A inhibitor and histamine is decomposed by MAO-B. Nevertheless, although the enzymes preferentially decompose their favorite substrates (Benedetti et al, 1980), in many cases they overlap, depending on the concentration of the enzyme and substrate (Goroshinskaia et al, 1986;Waldmeyer, 1987;Finberg et al, 1993;Shih and Chen, 1999).…”

Section: Resultsmentioning

confidence: 99%

Perinuclear localization of biogenic amines (serotonin and histamine) in rat immune cells

Csaba

Kovács

2006

Cell Biology International

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EDAC fixation, which polymerizes biogenic amines, and clorgyline, which blocks monoamine oxydase, were used to demonstrate the perinuclear and nuclear localization of histamine and serotonin (5-HT) of immune cells in rat peritoneal fluid and thymus. For detection, an immunocytochemical method combined with confocal microscopy was used. In peritoneal cells (lymphocytes) 5-HT formed spots around the nucleus, while histamine was localized diffusely. In thymocytes, 5-HT was distributed in patches, while histamine formed a garland around the nuclear envelope. Clorgyline enhanced the fluorescence and increased the number of fluorescent positive cells only for histamine, and then histamine-positive nuclei were also present. The results show that: (1) EDAC fixation demonstrates the presence of biogenic amines in immune cells, (2) using this fixation, the perinuclear localization of biogenic amines can be demonstrated, (3) the localization of the two amines is different and (4) the nuclear localization of histamine in thymocytes can be surmised and in mast cells (described previously) is proven again. The potential importance of the nuclear and near-nuclear localization of biogenic amines is discussed.

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Section: Resultsmentioning

confidence: 99%

Perinuclear localization of biogenic amines (serotonin and histamine) in rat immune cells

Csaba

Kovács

2006

Cell Biology International

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“…Although DAO was ®rst considered to be a cytoplasmic enzyme, there is recent evidence showing that DAO, as well as other tissue amine oxidases, can be membrane bound (endoplasmic reticulum) [25,64]. As histamine is an amine not only endogenous but also present in high amounts in some foods [72], DAO may be regarded as playing a role in xenobiotic metabolism.…”

Section: P L a S M A A N D T I S S U E A M I N E O X I D A S E S N O mentioning

confidence: 99%

Biotransformation of xenobiotics by amine oxidases

Benedetti

2001

Fundamemntal Clinical Pharma

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Although the cytochrome P450 (CYP) system ranks first in terms of catalytic versatility and the wide range of xenobiotics it detoxifies or activates to reactive intermediates, the contribution of amine oxidases and in particular of monoamine oxidases (MAOs) to the metabolism of xenobiotics is far from negligible but has been largely neglected. In this review on the involvement of amine oxidases in the metabolism of xenobiotics, the major characteristics reported for the CYP system (protein, reaction, tissue distribution, subcellular localisation, substrates, inhibitors, inducers, genetic polymorphism, impact of different physiopathological conditions on the activity, turnover) will be compared, whenever possible, with the corresponding characteristics of amine oxidases (MAOs in particular). The knowledge of the involvement of MAO-A, -B or both in the metabolism of a drug allows us to predict interactions with selective or non-selective MAO inhibitors (e.g. the metabolism of a drug deaminated by both forms of MAO is not necessarily inhibited in vivo by a selective MAO-A or -B inhibitor). If a drug is metabolized by MAOs, competitive interactions can occur with other drugs that are MAO substrates, e.g. with beta-adrenoceptor agonists and antagonists, prodrugs of dopamine, serotonin 5-HT1-receptor agonists as well as with primaquine, flurazepam and citalopram. Moreover, the knowledge of the involvement of MAOs in the metabolism of a drug may suggest possible, although not obligatory, interactions with tyramine-containing food or drink, with over the counter medicines sold to relieve the symptoms of coughs and colds (generally containing the indirectly-acting sympathomimetic amine phenylpropanolamine) or with phenylephrine-containing preparations. Finally, biotransformation by amine oxidases, as by CYP, does not always lead to detoxication but can produce toxic compounds.

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