Monoamine oxidase and agitation in psychiatric patients

Perković, Matea Nikolac; Štrac, Dubravka Švob; Erjavec, Gordana Nedić; Uzun, Suzana; Podobnik, Josip; Kozumplik, Oliver; Vlatković, Suzana; Pivac, Nela

doi:10.1016/j.pnpbp.2016.02.002

Cited by 19 publications

(9 citation statements)

References 168 publications

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“…It was assumed that the A allele of the MAO-B rs1799836 was associated with higher MAO-B activity [42,77] and, therefore, may result in lower subcortical dopamine levels. However, some studies reported higher enzyme activity in G allele carriers [78,79], while our previous studies reported no differences in platelet MAO-B activity in carriers of the A or G allele [80][81][82][83][84], questioning the hypothesis of its functionality. In addition, MAO-B rs1799836 was not found to be a functional polymorphism in a meta-analysis [19].…”

Section: Discussioncontrasting

confidence: 65%

The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia

Madžarac

Tudor

Šagud

et al. 2021

CIMB

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Negative symptoms of schizophrenia, including anhedonia, represent a heavy burden on patients and their relatives. These symptoms are associated with cortical hypodopamynergia and impaired striatal dopamine release in response to reward stimuli. Catechol-O-methyltransferase (COMT) and monoamine oxidase type B (MAO-B) degrade dopamine and affect its neurotransmission. The study determined the association between COMT rs4680 and rs4818, MAO-B rs1799836 and rs6651806 polymorphisms, the severity of negative symptoms, and physical and social anhedonia in schizophrenia. Sex-dependent associations were detected in a research sample of 302 patients with schizophrenia. In female patients with schizophrenia, the presence of the G allele or GG genotype of COMT rs4680 and rs4818, as well as GG haplotype rs4818-rs4680, which were all related to higher COMT activity, was associated with an increase in several dimensions of negative symptoms and anhedonia. In male patients with schizophrenia, carriers of the MAO-B rs1799836 A allele, presumably associated with higher MAO-B activity, had a higher severity of alogia, while carriers of the A allele of the MAO-B rs6651806 had a higher severity of negative symptoms. These findings suggest that higher dopamine degradation, associated with COMT and MAO-B genetic variants, is associated with a sex-specific increase in the severity of negative symptoms in schizophrenia patients.

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Section: Discussioncontrasting

confidence: 65%

The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia

Madžarac

Tudor

Šagud

et al. 2021

CIMB

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“…In addition, Snell et al (2002) showed that platelet MAO-B activity was significantly reduced in smokers compared to non-smokers in both males and females of different ethnic backgrounds [82]. The same association between MAO-B activity and smoking status was also reported in healthy subjects and various patients [64,80,85], although it was not investigated in patients with asthma.…”

Section: Discussionmentioning

confidence: 74%

Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma

Konjevod

Sreter²,

Popović‐Grle

et al. 2023

Biomolecules

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The complex role of the serotonin system in respiratory function and inflammatory diseases such as asthma is unclear. Our study investigated platelet serotonin (5-HT) levels and platelet monoamine oxidase B (MAO-B) activity, as well as associations with HTR2A (rs6314; rs6313), HTR2C (rs3813929; rs518147), and MAOB (rs1799836; rs6651806) gene polymorphisms in 120 healthy individuals and 120 asthma patients of different severity and phenotypes. Platelet 5-HT concentration was significantly lower, while platelet MAO-B activity was considerably higher in asthma patients; however, they did not differ between patients with different asthma severity or phenotypes. Only the healthy subjects, but not the asthma patients, carrying the MAOB rs1799836 TT genotype had significantly lower platelet MAO-B activity than the C allele carriers. No significant differences in the frequency of the genotypes, alleles, or haplotypes for any of the investigated HTR2A, HTR2C and MAOB gene polymorphisms have been observed between asthma patients and healthy subjects or between patients with various asthma phenotypes. However, the carriers of the HTR2C rs518147 CC genotype or C allele were significantly less frequent in severe asthma patients than in the G allele carriers. Further studies are necessary to elucidate the involvement of the serotonergic system in asthma pathophysiology.

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“…The maoB gene encodes MAOB in both the brain and platelets, so platelet-derived enzyme activity is sometimes regarded as a biological marker of psychopathology [56]. Increased platelet MAOB activity is associated with severe agitation [56] and decreased activity, with aggression-related personality traits [57] as well as with disinhibition in behavior and high impulsivity [58].…”

Section: Discussionmentioning

confidence: 99%

“…Increased platelet MAOB activity is associated with severe agitation [56] and decreased activity, with aggression-related personality traits [57] as well as with disinhibition in behavior and high impulsivity [58]. Ruchkin et al [58] hypothesized that low activity of platelet MAOB represents a nonspecific marker of predisposition to distress.…”

Section: Discussionmentioning

confidence: 99%

Changes in Gene Expression Profiles in Adult Rat Brain Structures after Neonatal Action of Dipeptidyl Peptidase-IV Inhibitors

et al. 2017

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Background: Previous studies have shown the development of emotional and motivational disorders, such as anxiety-depression-like disorders with increased aggression in adolescent and adult Wistar rats, occurs after neonatal exposure to the dipeptidyl peptidase-IV (DPP-IV, EC 3.4.14.5) inhibitors diprotin A and sitagliptin (postnatal days 5–18). Methods: In this study, using real-time PCR, we evaluated changes in the gene expression of serine protease DPP-IV and prolyl endopeptidase (PREP, EC 3.4.21.26; dpp4 and prep genes), monoamine oxidase А (maoA) and B (maoB), and serotonin transporter (SERT; sert) in the brain structures from 3-month-old rats after postnatal action of DPP-IV inhibitors diprotin A and sitagliptin. Results: Dpp4, sert, and maoB gene expression increased and maoA gene expression changed with a tendency to increase in the striatum of rats with neonatal sitagliptin action. The increase of maoA gene expression was also shown in the amygdala. An increase in prep gene expression was found in the striatum of rats with the neonatal action of diprotin A, and a decrease in maoB gene expression was observed in the amygdala. We detected a significant downward trend in sert gene expression in the frontal cortex and amygdala, as well as a tendency to increase in maoA gene expression in the hypothalamus. Discussion: These findings suggest that changes in the expression of the abovementioned genes are associated with the development of anxiety and depression, with increased aggression caused by the neonatal action of diprotin A and sitagliptin.

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Monoamine oxidase and agitation in psychiatric patients

Cited by 19 publications

References 168 publications

The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia

The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia

Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma

Changes in Gene Expression Profiles in Adult Rat Brain Structures after Neonatal Action of Dipeptidyl Peptidase-IV Inhibitors

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