Monoamine oxidase A (MAO A) inhibitors decrease glioma progression

Kushal, Swati; Wang, Weijun; Vaikari, Vijaya Pooja; Kota, Rajesh; Chen, Kevin; Yeh, Tzu-Shao; Jhaveri, Niyati; Groshen, Susan; Olenyuk, Bogdan; Chen, Thomas C.; Hofman, Florence M.; Shih, Jean C.

doi:10.18632/oncotarget.7283

Cited by 68 publications

(91 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It finally leads to mitochondrial biogenesis, metabolic reprogramming, and tumor cell differentiation [104]. 3Сlorgyline alone or with TMZ acts as monoamine oxidase A inhibitor and reduces tumor growth [125]. (4) TCA clomipramine and SSRIs directly interact with complex III of respiratory chain, decreasing O2 consumption and stimulating reactive oxygen species generation.…”

Section: Mitochondria Are the Central Hub Of The "Intrinsic" Apoptotimentioning

confidence: 99%

In Search of a Breakthrough Therapy for Glioblastoma Multiforme

Vasilev

Sofi

et al. 2018

Neuroglia

View full text Add to dashboard Cite

Glioblastoma multiforme (GBM) is an extremely malignant type of brain cancer which originates from astrocytes or their precursors. Glioblastoma multiforme cells share some features with astrocytes but are characterized by highly unstable genomes with multiple driver mutations and aberrations. Effective therapies for GBM are lacking and hardly any progress has been made in the last 15 years in terms of improving the outcomes for patients. The lack of new especially targeted anti-GBM medications has prompted scientists in academia around the world to test whether any of the currently approved drugs might be used to fight this devastating disease. This approach is known as repurposing. Dozens of drugs have been reported to have anti-GBM properties in vitro but there is no solid evidence for the clinical efficacy of any of them. Perhaps the most interesting group of those repurposed are tricyclic antidepressants but the mechanism of their action on GBM cells remains obscure. In this brief review we consider various approaches to repurpose drugs for therapy of GBM and highlight their limitations. We also pay special attention to the mitochondria, which appear to be intimately involved in the process of apoptosis and could be a focus of future developments in search of a better treatment for patients suffering from GBM.

show abstract

Section: Mitochondria Are the Central Hub Of The "Intrinsic" Apoptotimentioning

confidence: 99%

In Search of a Breakthrough Therapy for Glioblastoma Multiforme

Vasilev

Sofi

et al. 2018

Neuroglia

View full text Add to dashboard Cite

show abstract

“…In most cell types in the body, an enzyme was discovered by Mary Bernheim in the liver and was called the name of the tyramine oxide [16]. MAO plays a crucial role in some mental and neurological disorders, including depression disease [17].…”

Section: Introductionmentioning

confidence: 99%

The effect of Aloe Vera extract on Acetylcholinesterase AchE and Monoamine Oxidase MAO enzymes

Shaker

2019

MJS

View full text Add to dashboard Cite

Abstract The aim of this study is to evaluate the inhibitory potency of ethanol extracts of Aloe vera plant on Acetylcholinesterase AchE and Monoamine Oxidase MAO enzymes activities in vitro .Enzyme kinetic studies using ( Michaelis-Menten and Lineweaver-Burk equations ) were used to establish the type of inhibition. The Aloe vera extract showed a significantly higher percentage of inhibition. The activity observed in this study tends to validate some of the traditional claims of using Aloe vera as a functional food, and used as a treatment for many diseases that are related to the nervous system and it has no side effects such as some medications الخلاصة الهدف من هذه الدراسة تقييم فعالية مثبطة في مستخلص الإيثانول من نبات الاوليفيرا على نشاط الانزيمات أسيتيل كولين استريز و أوكسيديز احادي الامين في المختبر . استخدمت الدراسات الحركية الإنزيمية باستخدام معادلات (مايكل مينتين و لينويفر- بورك ) لتحديد نوع التثبيط. وأظهرت مستخلصات الاوليفيرا أعلى نسبة تثبيط بشكل ملحوظ. ان النشاط الذي لوحظ في هذه الدراسة يميل إلى التحقق من صحة بعض المطالبات التقليدية في استخدام الاوليفيرا كغذاء وظيفي ، وتستخدم كعلاج لكثير من الأمراض التي ترتبط بالجهاز العصبي وليس لها أي آثار جانبية ملحوظة كما في بعض الأدوية

show abstract

“…Overexpression of MAOA has also been found in cholangiocarcinoma, Hodgkin's lymphoma and glioma. [12][13][14] A recent research result indicated that nonsmall cell lung cancer (NSCLC) tissues exhibited upregulation of MAOA compared with surrounding normal lung tissues. 15 Furthermore, a close relationship has been observed between increased MAOA expression in NSCLC tissues and Slug, N-cadherin and TWIST expression, EMT and the development of clinicopathological features of NSCLC such as later stage and lymph node metastasis.…”

Section: Introductionmentioning

confidence: 99%

Potential monoamine oxidase A inhibitor suppressing paclitaxel‐resistant non‐small cell lung cancer metastasis and growth

Yang

Zhao

et al. 2020

Thoracic Cancer

View full text Add to dashboard Cite

Background: High expression of monoamine oxidase A (MAOA) in nonsmall cell lung cancer (NSCLC) is related to epithelial-mesenchymal transition (EMT) and the development of clinicopathological features of NSCLC. Nevertheless, the role of MAOA in drug resistance still remains unclear. Hence, the aim of this article was to evaluate a previously synthesized MAOA inhibitor (G11) on inhibiting paclitaxel-resistant NSCLC metastasis and growth. Methods: First, MAOA expression level was evaluated in several NSCLC cell lines. An MTT assay was used to validate the inhibitory effect of G11 on NSCLC cells in vitro. Second, gene expression in G11-treated H460/PTX cells was analyzed by microarray gene expression. Third, transwell assay was performed to assess the invasion and metastasis of G11-treated A549/PTX and H460/PTX cells and western blot assay used to analyze vital protein expression level in G11-treated H460/PTX cells. Finally, the antimetastatic effect of G11 was tested in an NSCLC in vivo model. Results: Our data revealed that G11 significantly inhibited the viability of paclitaxel (PTX)-resistant NSCLC cell lines (A549/PTX and H460/PTX). G11 dramatically reduced the expression of MAOA in A549/PTX and H460/PTX cells, which exhibited relatively high MAOA expression levels. Additionally, G11 was found to hinder A549/PTX and H460/PTX cell migration and invasion. Furthermore, the in vivo study indicated that the coadministration of G11 and paclitaxel significantly suppressed tumor metastasis in H460/PTX lung metastasis models. Conclusions: These findings indicated G11 showed a moderate inhibitory effect on paclitaxel-resistant NSCLC metastasis and growth, and support further investigation on MAOA potentially as a promising therapeutic target for paclitaxel-resistant NSCLC treatment. Key points Significant findings of the study: • Inhibition of MAOA might contribute to the suppression of metastasis and growth in PTX-resistant NSCLC cells. What this study adds • This study explored the potential function of MAOA in drug-resistant NSCLC and might consider MAOA as a promising target for the treatment of drugresistant NSCLC.

show abstract

Monoamine oxidase A (MAO A) inhibitors decrease glioma progression

Cited by 68 publications

References 21 publications

In Search of a Breakthrough Therapy for Glioblastoma Multiforme

In Search of a Breakthrough Therapy for Glioblastoma Multiforme

The effect of Aloe Vera extract on Acetylcholinesterase AchE and Monoamine Oxidase MAO enzymes

Potential monoamine oxidase A inhibitor suppressing paclitaxel‐resistant non‐small cell lung cancer metastasis and growth

Contact Info

Product

Resources

About