Monoamine Oxidase A Inhibits Lung Adenocarcinoma Cell Proliferation by Abrogating Aerobic Glycolysis

Huang, Yu‐Min; Zhao, Wei; Ouyang, Xiaoping; Feng, Weiwei; Tao, Yujian; Shi, Minhua

doi:10.3389/fonc.2021.645821

Cited by 5 publications

(4 citation statements)

References 41 publications

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“…This approach identified more than half the genes (17/27) in these BRCA samples that have recently been recognised for their tumour-suppressive capacities in a range of sporadic cancers, with others apparently underexplored ( Table S1 , Tab#2). Several prime examples are functionally linked to metabolism: monoamine oxidase A (MAOA) inhibits aerobic glycolysis and immunity in lung cancer [ 49 ]; Integral Membrane Protein 2A (ITM2A) in BRCA induces PD-1 and higher tumour infiltrating lymphocyte (TIL) infiltration [ 50 ]; and GRB2-associated binding protein 3 (GAB3) drives natural killer cell priming and expansion [ 51 ].…”

Section: Resultsmentioning

confidence: 99%

Establishing the Link between X-Chromosome Aberrations and TP53 Status, with Breast Cancer Patient Outcomes

Caramia,

Speed,

Shen

et al. 2023

Cells

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Ubiquitous to normal female human somatic cells, X-chromosome inactivation (XCI) tightly regulates the transcriptional silencing of a single X chromosome from each pair. Some genes escape XCI, including crucial tumour suppressors. Cancer susceptibility can be influenced by the variability in the genes that escape XCI. The mechanisms of XCI dysregulation remain poorly understood in complex diseases, including cancer. Using publicly available breast cancer next-generation sequencing data, we show that the status of the major tumour suppressor TP53 from Chromosome 17 is highly associated with the genomic integrity of the inactive X (Xi) and the active X (Xa) chromosomes. Our quantification of XCI and XCI escape demonstrates that aberrant XCI is linked to poor survival. We derived prognostic gene expression signatures associated with either large deletions of Xi; large amplifications of Xa; or abnormal X-methylation. Our findings expose a novel insight into female cancer risks, beyond those associated with the standard molecular subtypes.

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Section: Resultsmentioning

confidence: 99%

Establishing the Link between X-Chromosome Aberrations and TP53 Status, with Breast Cancer Patient Outcomes

Caramia,

Speed,

Shen

et al. 2023

Cells

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“…Similar results can be observed in lung cancer. Monoamine oxidase A has a positive to poor prognosis and can promote aerobic glycolysis through HK2 [ 155 ]. In prostate cancer, increased monoamine oxidase A induces ROS-mediated apoptosis under androgen deprivation [ 156 ].…”

Section: Possible Connections Between Let-7 -Mediated Glycolysis and Autophagy In Cancer Progressionmentioning

confidence: 99%

The Metabolism Reprogramming of microRNA Let-7-Mediated Glycolysis Contributes to Autophagy and Tumor Progression

Liao

2021

IJMS

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Cancer is usually a result of abnormal glucose uptake and imbalanced nutrient metabolization. The dysregulation of glucose metabolism, which controls the processes of glycolysis, gives rise to various physiological defects. Autophagy is one of the metabolic-related cellular functions and involves not only energy regeneration but also tumorigenesis. The dysregulation of autophagy impacts on the imbalance of metabolic homeostasis and leads to a variety of disorders. In particular, the microRNA (miRNA) Let-7 has been identified as related to glycolysis procedures such as tissue repair, stem cell-derived cardiomyocytes, and tumoral metastasis. In many cancers, the expression of glycolysis-related enzymes is correlated with Let-7, in which multiple enzymes are related to the regulation of the autophagy process. However, much recent research has not comprehensively investigated how Let-7 participates in glycolytic reprogramming or its links to autophagic regulations, mainly in tumor progression. Through an integrated literature review and omics-related profiling correlation, this review provides the possible linkage of the Let-7 network between glycolysis and autophagy, and its role in tumor progression.

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“…[18] Additionally, MAOA which catalyzes the oxidative deamination of dopamine, serotonin, and the other amines is overexpressed in NSCLC, [19] while another study suggested that MAOA is downregulated in LUAD. [20] Thus, we speculate that the NRCRGs model might exist prognostic value for patients with LUAD. In this study, we integrated the genomic information of LUAD patients from multiple datasets to develop and validate a 3 NRCRGs prognostic model named “Neurotransmitter release cycle (NRC) score.” Furthermore, the NRC score constructed based on the prognostic model was associated with immunotherapy-related anti-cancer immunity and inflamed TME characteristics.…”

Section: Introductionmentioning

confidence: 98%

Neurotransmitter release cycle-related genes predict the prognosis of lung adenocarcinoma

Wang

et al. 2022

Medicine

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Because of the limitations of therapeutic approaches, patients suffering from lung adenocarcinoma (LUAD) have unsatisfactory prognoses. Studies have shown that neurotransmitters participated in tumorigenesis and development. In LUAD, the expression of neurotransmitter release cycle-related genes (NRCRGs) has been reported to be disordered. This study aimed to study the correlation between NRCRGs and LUAD. In this study, based on the Cancer Genome Atlas cohort, consensus clustering analyses were performed on ten neurotransmitter release cycle-related (NRCR) differentially expressed genes. Neurotransmitter release cycle (NRC) scores were derived by the Least Absolute Shrinkage and Selection Operator-Cox regression model constituted by 3 NRCRGs. Univariate and multivariate Cox regression analyses were performed to evaluate the prognosis value of the NRC score. In addition, single-Sample Gene Set Enrichment Analysis and CIBERSORT were conducted in the Cancer Genome Atlas cohort. Finally, gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses were also performed. As a result, the NRC-low group showed a good prognosis instead of the NRC-high group. NRC score was identified to be an independent prognosis factor for LUAD. In general, the NRC score based on the prognostic model was found to be closely correlated with immunotherapyrelated anti-cancer immunity and inflamed tumor microenvironment. Functional enrichment results demonstrated that differentially expressed genes between 2 NRC groups were closely correlated with DNA replication, cell-substrate adhesion, Golgi vesicle transport, MAPK signal pathway, and many others. Novel biomarkers were offered for predicting the prognoses of LUAD patients. The NRC score might contribute to guiding LUAD patients with immunotherapy selection.Abbreviations: APM = antigen processing machinery, AUC = area under curve, DEGs = differentially expressed genes, EMT = epithelial to mesenchymal transition, FDR = false discovery rate, GEO = the Gene Expression Omnibus, GO = gene ontology, ICPGs = immune checkpoint genes, ICPs = immune checkpoints, ICR = immunologic constant of rejection, KEGG = Kyoto Encyclopedia of Genes and Genomes, LASSO = the Least Absolute Shrinkage and Selection Operator, LUAD = Lung adenocarcinoma, M3R = muscarinic receptors, NRC = neurotransmitter release cycle, NRCR = neurotransmitter release cyclerelated, NRCRGs = neurotransmitter release cycle-related genes, NSCLC = non-small cell lung cancer, NTRs = neurotransmitter receptors, OSs = overall survivals, TCGA = The Cancer Genome Atlas, TME = tumor microenvironment.

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Monoamine Oxidase A Inhibits Lung Adenocarcinoma Cell Proliferation by Abrogating Aerobic Glycolysis

Cited by 5 publications

References 41 publications

Establishing the Link between X-Chromosome Aberrations and TP53 Status, with Breast Cancer Patient Outcomes

Establishing the Link between X-Chromosome Aberrations and TP53 Status, with Breast Cancer Patient Outcomes

The Metabolism Reprogramming of microRNA Let-7-Mediated Glycolysis Contributes to Autophagy and Tumor Progression

Neurotransmitter release cycle-related genes predict the prognosis of lung adenocarcinoma

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