Monoamine innervation of bed nucleus of stria terminalis: An electron microscopic investigation

Phelix, Clyde F.; Liposits, Zsolt; Paull, Willis K.

doi:10.1016/0361-9230(92)90218-m

Cited by 121 publications

(94 citation statements)

References 60 publications

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“…This would facilitate DA release from A10dc neurons via ascending projections to the BSTld to sustain or enhance the activity of CRF neurons through D 1 -mediated DA neurotransmission. The observation that the BST has moderate to high levels of dopamine D 1 receptors (Savasta et al, 1986;Scibilia et al, 1992) and receives heavy dopaminergic inputs (present study) that make direct synaptic contact with CRF neurons (Phelix et al, 1992) supports the idea that DA plays a major role in controlling the activity of CRF neurons in the BSTld.…”

Section: Discussionsupporting

confidence: 85%

“…Potential sites of convergence between these systems may exist within the central nucleus of the amygdala (CeA) and the bed nucleus of the stria terminalis (BST), interconnected structures of the extended amygdala that share similar cytoarchitecture and afferent/efferent connections (Alheid et al, 1995). Both areas have a high density of CRF-containing neurons (Cassell et al, 1986;Moga et al, 1989) and receive dopaminergic inputs that make direct synaptic contact with CRF neurons (Phelix et al, 1992;Eliava et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Behavioral and Anatomical Interactions between Dopamine and Corticotropin-Releasing Factor in the Rat

Meloni¹,

Gerety²,

Knoll³

et al. 2006

J. Neurosci.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Behavioral and Anatomical Interactions between Dopamine and Corticotropin-Releasing Factor in the Rat

Meloni¹,

Gerety²,

Knoll³

et al. 2006

J. Neurosci.

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“…The extended amygdala, including CeA and BSTL, is an important mediator of the stress response, fear and anxiety, and the rewarding and aversive aspects of addictive drugs (Herman and Cullinan, 1997;Davis and Shi, 1999;Koob, 1999). Whereas norepinephine (NE) and serotonergic afferents Phelix et al, 1992) may contribute to cocaine's effects in these regions, the CeA and BSTL receive intense DA projections Freedman and Cassell, 1994). Activation of DA afferents to the extended amygdala is essential in mediating many of the actions of addictive drugs (Caine et al, 1995;Hurd et al, 1997;Epping-Jordan et al, 1998).…”

Section: Mechanisms Underlying Developmental Changes In Cocaine Responsementioning

confidence: 99%

Adolescent Maturation of Cocaine-Sensitive Neural Mechanisms

Cao

Lotfipour

Loughlin

et al. 2007

Neuropsychopharmacol

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Both clinical and animal studies have shown that adolescents undergo a late maturation of the central nervous system, which may underlie adolescent typical behaviors. In particular, decreased behavioral response to cocaine has been found in adolescents as compared to adults. In the present study, cocaine was used as a tool to explore adolescent brain maturation. Juvenile (postnatal day (P) 27), adolescent (P37), and adult (P90) male Sprague-Dawley rats were treated acutely with cocaine (750 mg/kg/injection Â 2, i.v.), and c-fos mRNA expression, a marker of neuronal activation, was evaluated by in situ hybridization. Cocaine-induced c-fos mRNA was similar across ages in the dorsal caudate putamen (CPu), nucleus accumbens, and lateral bed nucleus of the stria terminalis. In contrast, there was a diminished response in juvenile/adolescent ventral CPu and in juvenile central nucleus of the amygdala, and an increased response in juvenile/adolescent cortex. Further studies evaluated the mechanism of the late maturation of cocaine response in ventral CPu. No significant age differences were observed in regional dopamine (DA) transporter binding. Although striatal DA content was significantly reduced at P27 as compared to adult, there was no difference between dorsal and ventral subregions. In contrast, basal-and cocaineinduced extracellular DA overflow, as measured by in vivo microdialysis, was lower in juvenile ventral CPu than in the adults. This age difference was not observed in dorsal CPu. These findings suggest that impulse activity in DA afferents to ventral CPu is immature in adolescents. In conclusion, the present study showed that cocaine-sensitive neuronal circuits continue to mature during adolescence.

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“…Here we sought to determine whether cocaine selfadministration would produce specific alterations in the neuromodulatory effects of DA in the oval subregion of the bed nucleus of the stria terminalis (ovBST), which is characterized by a high density of tyrosine hydroxylase-positive terminals, DARPP-32, and D2-like DA receptors (D2Rs) (Deutch et al, 1988;Gustafson and Greengard, 1990;Schalling et al, 1990;Phelix et al, 1992;Scibilia et al, 1992;Freedman and Cassell, 1994;Hasue and Shammah-Lagnado, 2002;Meloni et al, 2006;Krawczyk et al, 2011). We have previously shown that DA causes a D2R-dependent reduction of GABA A -mediated inhibitory transmission in the ovBST of drug-naive rats (Krawczyk et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

A Switch in the Neuromodulatory Effects of Dopamine in the Oval Bed Nucleus of the Stria Terminalis Associated with Cocaine Self-Administration in Rats

Krawczyk¹,

Sharma²,

Mason³

et al. 2011

Journal of Neuroscience

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Chronic exposure to drugs of abuse alters brain reward circuits and produces functional changes in the dopamine (DA) system. However, it is not known whether these changes are directly related to drug-driven behaviors or whether they simply are adaptive responses to long-term drug exposure. Here, we combined the rat model of cocaine self-administration with brain slice electrophysiology to identify drug-use related alterations in the neuromodulatory effects of DA in the oval bed nucleus of the stria terminalis (ovBST), a robust DA terminal field. Long-Evans rats self-administered cocaine intravenously (0.75 mg/kg/injection) for an average of 15 d, on reward-lean or -rich schedules of reinforcement. Brain slice recordings conducted 20 h after the last self-administration session revealed a reversal of the neuromodulatory effect of DA on GABA A -IPSCs. Specifically, the effect of DA switched from a D2-mediated decrease in drug-naive rats to a D1-receptor-mediated increase in GABA A -IPSC in cocaine self-administering rats. Furthermore, the switch in DA modulation of GABA A -IPSC remained after a 30 d withdrawal period. In contrast, this switch was not observed after the acquisition phase of cocaine self-administration, when rats received cocaine passively, or in rats maintaining sucrose self-administration. Therefore, our study reveals a reversal in the effects of DA on inhibitory transmission, from reduction to enhancement, in the ovBST of cocaine selfadministering rats. This change was unique to voluntary intake of cocaine and maintained after a withdrawal period, suggesting a mechanism underlying the maintenance of cocaine self-administration and perhaps craving during drug-free periods.

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Monoamine innervation of bed nucleus of stria terminalis: An electron microscopic investigation

Cited by 121 publications

References 60 publications

Behavioral and Anatomical Interactions between Dopamine and Corticotropin-Releasing Factor in the Rat

Behavioral and Anatomical Interactions between Dopamine and Corticotropin-Releasing Factor in the Rat

Adolescent Maturation of Cocaine-Sensitive Neural Mechanisms

A Switch in the Neuromodulatory Effects of Dopamine in the Oval Bed Nucleus of the Stria Terminalis Associated with Cocaine Self-Administration in Rats

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