Monoamide Derivatives of EDTA Incorporating Pendent Carboxylates or Pyridyls: Synthesis, Metal Binding, and Crystal Structure of a Dinuclear Ca²⁺ Complex Featuring Bridging Na⁺ Ions

Abstract

This is the peer reviewed version of the following article: Mulla, R. S., Pitarch-Jarque, J., Garcia-Espana, E., Desa, T. Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. AbstractEDTA is a powerful, cheap and widely-used chelating unit for a large range of metal ions.To link it covalently to other molecules, the formation of an amide bond using one of the carboxylates is an attractive and simple approach, even though it may compromise metal ion

On the Antibacterial Activity of Azacarboxylate Ligands: Lowered Metal Ion Affinities for Bis‐amide Derivatives of EDTA do not mean Reduced Activity

“…Two symmetrical bis‐amide derivatives of EDTA , AmGly 2 and AmPy 2 , have been prepared via novel routes and their activities in inhibiting bacterial growth have been evaluated and compared with that of EDTA , which is widely used as a bacteriostatic agent. The solid state structures of metal free AmGly 2 and its Mg 2+ complex Mg ( AmGly 2 )NO 3 have also been determined, with the latter adopting an extended polymeric structure not unlike previous EDTA amides studied …”