Monoacylglycerol of 7,10-Dihydroxy-8(E)-octadecenoic Acid Enhances Antibacterial Activities against Food-Borne Bacteria

Abstract

Conversion of free fatty acids into monoacylglycerol gives rise to new structural properties, particularly amphipathic property. Therefore, monoacylglycerols are widely used in pharmaceutical and food industries and are also reported to facilitate better absorption into the human body. A functional fatty acid when transformed into a monoacylglycerol will possibly conserve both the original functionality and amphipathic property. The compound 7,10-dihydroxy-8(E)octadecenoic acid (DOD) was generated from oleic acid by Pseudomonas aeruginosa PR3 and was known to contain antimicrobial activities against a broad range of food-borne and plant pathogenic bacteria. Here, we attempted to convert DOD into its monoacylglycerol form using lipase for producing an amphipathic antibacterial agent. Consequently, the monoacylglycerol of DOD (DOD-MAG) was successfully produced by coincubating DOD, glycerol, and lipase at 30 °C. The maximum conversion yield reached 70% after 12 h of incubation. Antibacterial activity of DOD-MAG was enhanced by 8 times from the original activity of DOD against food-borne bacteria.

The role of volatile organic compounds for assessing characteristics and severity of non-cystic fibrosis bronchiectasis: an observational study

“…The multivariate analysis of P. aeruginosa isolation also suggested that octadecenoic acid and phenol might be the most important independent factors influencing the P. aeruginosa isolation. The upregulated level of octadecenoic acid in patients with P. aeruginosa isolation might be associated with its antibacterial activity ( 43 ).…”

GC/MS Profiling and Ex Vivo Antibacterial Activity of Salvadora persica (Siwak) against Enterococcus faecalis as Intracanal Medicament

“…In addition, there are γ -sitosterol (25.76%), n -hexadecanoic acid (4.27%), and ( Z )-11-octadecenoic acid (3.16%) that are reported as potent broad-spectrum antimicrobials [ 38 – 42 ]. Moreover, SPE has antimicrobial effect against both Gram-positive and Gram-negative bacteria due to the presence of carvacrol (0.57%) confirmed by Memar et al .…”

Biosynthesized nanosilver as anti-oxidant, anti-apoptotic and anti-inflammatory agent against Plasmodium chabaudi infection in the mouse liver

“…The biosynthesized NS from I. oblongifolia is rapid, cheap and ecofriendly and also could suppress the induced parasitemia on day 7 postinfection with P. chabaudi . This is due to the presence of active compounds like octadecenoic acid and 2,6-di-t-butyl-p-benzoquinone in the I. oblongifolia leaves ( Chen et al, 2019 , Dkhil et al, 2020 ).…”