Mono- and polynuclear complexes of Pt(II) with polypyridyl ligandsSynthesis, spectroscopic and structural characterization and cytotoxic activity

Synthesis, structural characterisation and biological studies of new mononuclear platinum(II) complexes with sterically hindered heterocyclic ligands

“…This observation suggests that the mechanism underlying the antitumor activity of complexes 1 and 3 might be different from that of cisplatin and very close to those reported by us for polynuclear ionic platinum complexes with triazine derived heterocycles [19,20]. …”

Synthesis of platinum complexes with 2-(5-perfluoroalkyl-1,2,4-oxadiazol-3yl)-pyridine and 2-(3-perfluoroalkyl-1-methyl-1,2,4-triazole-5yl)-pyridine ligands and their in vitro antitumor activity

“…The coordination mode of the complexes in solution was determined by using the 1 H NMR spectra and the assignments of resonances were based on literature data [40,9] and are in good agreement with proposed structure. The numbering of protons used for 1 H NMR is shown in Scheme 2.…”

“…In the past years, successful approaches have been employed to solve these drawbacks, combining platinum-based drugs with some other active pharmacophore so that a synergic action can be obtained [6]. Oxadiazole and triazole have been recently used for complexation of metal such as copper, nickel [7], palladium [8] and platinum [9]; 1,2,4-oxadiazoles have been widely studied for their chemistry [10][11][12], these heterocycles have gained attention for their pharmaceutical properties, and additionally, the presence of the fluorinated moiety opens the way to new fluorine-induced activity with respect to corresponding non-fluorinated systems [13][14][15][16] and application in materials [17][18][19][20][21]. In particular, a series of Pt(II) complexes with 1,2,4-oxadiazole derivatives as ligands have shown cytotoxic activity towards human ovarian cancer, and also in colon and testicular cancer cell lines.…”

Synthesis, crystal structure, luminescent property and antibacterial activity of lanthanide ternary complexes with 2,4,6-tri(2-pyridyl)-s-triazine

“…For example, Pt (II) complexes with TPTZ were found to act as effective death inducers in human colon rectal carcinoma HT29 cells and showed cytotoxic activity [43,44] [48,49]. However, studies on biological activities of the rare earth metal complexes with TPTZ have not been reported.…”