Mono‐ and penta‐nuclear self‐assembled silver(I) complexes of pyrazolyl s‐triazine ligand; synthesis, structure and antimicrobial studies

Abstract

The self‐assembled [Ag (PTDM)NO3] (1), [Ag (PTDM)2(H2O)]ClO4.H2O (2) and [Ag5(PTDM)4(H2O)6(ClO4)4]ClO4.2H2O (3) complexes were synthesized by the direct mixing of AgX (X = NO3¯ or ClO4¯) and 4,4′‐[6‐(3,5‐dimethyl‐1H‐pyrazol‐1‐yl)‐1,3,5‐triazine‐2,4‐diyl]dimorpholine (PTDM) ligand in water–methanol mixture. The coordination numbers of silver range from three to five. Complex 3 is a rare case in which one nitrogen atom from the same s‐triazine core of the PTDM ligand has a μ(1,1) bridging mode between Ag1 and Ag2 in the penta‐nuclear array with Ag1–N1 and Ag2–N1 distances of 2.666(4) and 2.418(3) Å, respectively. Its 3D topology has a kind of primitive dense packing derived from the α‐Po type structure. Hirshfeld analysis showed that the percentages of the O…H hydrogen bonds were 32.4, 25.4, and 42.0% in complexes 1–3, respectively. While the ligand showed no antimicrobial activity at the applicable concentration, the penta‐nuclear complex 3 had higher antibacterial (MIC = 3.7 μmol/L) and antifungal (14.6 μmol/L) potencies toward the tested microbes compared with complexes 1 and 2. Also, the killing doses of 3 were in the range of 7.3–58.5 μmol/L compared with 18.2–291.1 and 20.1–160.6 μmol/L for 1 and 2, respectively. It is clear that the higher Ag‐content in 3 could be the main reason for its higher antimicrobial activity.

Synthesis and characterization of some binuclear metal complexes with a pentadentate azodye ligand: An experimental and theoretical study

“…[30,31] The ligand field parameters Dq = 832.5 cm −1 , B = 823 cm −1 , β 35 = 0.847 cm −1 , ν 2= ν 1 = 2.007, and σ = 18.06% for the cobalt complex supported its octahedral configuration. [32,33] The nickel complex revealed four bands at 10235, 17520, 24850 and 32750 cm −1 consistent with 3…”

“…Therefore, to overcome the growing resistance of antimicrobial agents, researchers are developing new classes of antimicrobial drugs with adequate mechanisms. In recent years, transition metal complexes, [1][2][3][4][5] which have attracted substantial interest in bioinorganic chemistry as metal-based drugs, have been found to be good candidates for their efficacy.…”

Silver(I) complexes ofN,N′‐diarylformamidine ligands: Synthesis, crystal structures, and in vitro antibacterial studies

“…[7] Silver(I) complexes of pyrazolyl s-triazine were observed to have antimicrobial properties which depended on the nuclearity of the complexes. [8] An investigation by El-Ansary et al [9] showed the enhanced antimicrobial activity of Agcoumarin complexes compared with the free ligands, and similar results were also obtained for Ag-isonicotinic acid complexes. [10] Interestingly, Ag-naphthalenol Schiff base complexes showed manifold pharmaceutical therapy, namely, anticancer, antioxidant and antimicrobial offering combination drug treatment at one goal.…”

A New Pt(II) Complex with Anionic s-Triazine Based NNO-Donor Ligand: Synthesis, X-ray Structure, Hirshfeld Analysis and DFT Studies

“…Additionally, some Pd(II)-s-triazine complexes have been constructed and assessed against breast cancer cell lines (MCF7 and MDA-MB-231) and have exhibited good potentials [15,16]. The design of new s-triazinebased ligands and their coordination modes with different metal centers is still a challenge [17][18][19]. Recently, Barakat et During our study, we have explored the utility of the hydrazono-s-triazine-based ligand towards metalation with the divalent platinum ion to synthesize a new Pt(II) complex based on s-triazine hydrazone ligand (Figure 1).…”

“…Additionally, some Pd(II)- s -triazine complexes have been constructed and assessed against breast cancer cell lines (MCF7 and MDA-MB-231) and have exhibited good potentials [ 15 , 16 ]. The design of new s -triazine-based ligands and their coordination modes with different metal centers is still a challenge [ 17 , 18 , 19 ]. Recently, Barakat et al designed, synthesized and characterized a new hydrazono- s -triazine-based ligand and later explored the coordination chemistry of this ligand with a palladium(II) center.…”