Mono‐ and bis(steroids) containing a cyclooctane core: Synthesis, antiproliferative activity, and action on cell cytoskeleton microtubules
Olga V. Ryzhikova,
Aleksandra S. Churkina,
Kseniya N. Sedenkova
et al.
Abstract:Steroid dimers of natural and synthetic origin possess an unusual and complex molecular architecture that may lead to the realization of peculiar effects in biological systems, in particular in different cancer cell lines. In the present work, diastereoselective ring‐opening of mono‐ and polyoxiranes, containing a cyclooctane core, by azide‐anion was performed to yield a series of azidoalcohols with different types of symmetry. The products were involved in copper‐catalyzed azyde‐alkyne cycloaddition (CuAAC) r… Show more
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