Mono- and binuclear Ru(II) arene complexes with (fluoro substituted) picolinic acid: Synthesis, characterization and cytotoxicity

Abstract

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Experimental and theoretical approaches on structural, spectroscopic (FT‐IR and UV‐Vis), nonlinear optical, and molecular docking analyses for Zn (II) and Cu (II) complexes of 6‐chloropyridine‐2‐carboxylic acid

“…The obtained results demonstrated that the final complexes exhibit a higher inhibitory effect than both metal salts and ligands. In another study, it was reported that Ru (II) complexes of pyridine‐2‐carboxylic acid displayed moderate antiproliferative effects toward colorectal carcinoma (HCT116) and cervix adenocarcinoma (HeLa) 26 . Buczkowska et al 27 performed a comprehensive study about cytotoxic and antimicrobial activities of Cu (II), Co (II), Pt (II), and Zn (II) complexes with N,O‐chelating heterocyclic carboxylates and reported that these complexes have interesting cytotoxic activities in various human cancer cell lines.…”

Conjugates Containing Two and Three Trithiolato-Bridged Dinuclear Ruthenium(II)-Arene Units as In Vitro Antiparasitic and Anticancer Agents

“…Some compounds were shown to exert their anticancer activity by different modes of action compared to established drugs, including enzyme inhibition or crosslinking of DNA or proteins [ 78 , 80 , 81 ]. Numerous polynuclear half-sandwich metal-arene (ruthenium, osmium, rhodium, iridium) complexes have been investigated for their anticancer, antibacterial or antiparasitic properties [ 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 ].…”

Ruthenium(II) Diphosphine Complexes with Mercapto Ligands That Inhibit Topoisomerase IB and Suppress Tumor Growth In Vivo

“…(I) These complexes exhibited remarkable cytotoxic action against the A549 and MDA-MB-231 cancer cell lines, which are better than most of the complexes reported in the literature. − This behavior probably resulted from the good lipophilicity of this class of complexes.…”

“…The slides were stained immediately before analysis using 40 μg mL –1 acridine orange, and the binucleated cells with 1–4 MN were scored at 1000× magnification. Additionally, the frequencies of NPBs and NBUDs were evaluated using the criteria of Fenech et al The NDI was also calculated to evaluate the altered mitotic activity and/or cytostatic effects according to eq : where M1, M2, M3, and M4 are the number of cells with one, two, three, and four nuclei and N is the number of cells assayed. A total of 500 cells per treatment were analyzed or NDI calculated and 1000 binucleated cells for the MN, NPB, and NBUD frequencies.…”

“…The slides were stained immediately before analysis using 40 μg mL −1 acridine orange, and the binucleated cells with 1−4 MN were scored at 1000× magnification. Additionally, the frequencies of NPBs and NBUDs were evaluated using the criteria of Fenech et al 41 The NDI was also calculated to evaluate the altered mitotic activity and/or cytostatic effects according to eq 5: 71…”