Monkeypox virus (MPX) in humans a concern: Trespassing the global boundaries – Correspondence

Thakur, Vikram; Thakur, Pryanka; Srivastava, Sonakshi; Kumar, Pradeep

doi:10.1016/j.ijsu.2022.106703

Cited by 19 publications

(20 citation statements)

References 4 publications

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“…[38][39][40][41][42][43] Recently, the number of patients of monkeypox has increased dramatically, provoking great concern. [44][45][46][47][48][49] For this epidemic to be controlled, monkeypox virus must be better understood and re-evaluated. 50,51 Here, we review the recent investigations on monkeypox, including epidemiology of monkeypox, monkeypox virus reservoirs, novel transmission patterns, mutations and mechanisms of viral infection, clinical characteristics, laboratory diagnosis and treatment measures, as well as prevention of monkeypox infection.…”

Section: Introductionmentioning

confidence: 99%

Monkeypox: epidemiology, pathogenesis, treatment and prevention

Huang

Wang

2022

Sig Transduct Target Ther

112

120

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Monkeypox is a zoonotic disease that was once endemic in west and central Africa caused by monkeypox virus. However, cases recently have been confirmed in many nonendemic countries outside of Africa. WHO declared the ongoing monkeypox outbreak to be a public health emergency of international concern on July 23, 2022, in the context of the COVID-19 pandemic. The rapidly increasing number of confirmed cases could pose a threat to the international community. Here, we review the epidemiology of monkeypox, monkeypox virus reservoirs, novel transmission patterns, mutations and mechanisms of viral infection, clinical characteristics, laboratory diagnosis and treatment measures. In addition, strategies for the prevention, such as vaccination of smallpox vaccine, is also included. Current epidemiological data indicate that high frequency of human-to-human transmission could lead to further outbreaks, especially among men who have sex with men. The development of antiviral drugs and vaccines against monkeypox virus is urgently needed, despite some therapeutic effects of currently used drugs in the clinic. We provide useful information to improve the understanding of monkeypox virus and give guidance for the government and relative agency to prevent and control the further spread of monkeypox virus.

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Section: Introductionmentioning

confidence: 99%

Monkeypox: epidemiology, pathogenesis, treatment and prevention

Huang

Wang

2022

Sig Transduct Target Ther

112

120

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“…Despite the fact that global reporting of MPX cases in this outbreak has asserted sexual associations, MPX is not a sexually transmitted pathogen. Recent cases have indicated a higher infection rate among males [ 20 ]. Infection is often caused by dangerous interactions with wild animals.…”

Section: Epidemiologymentioning

confidence: 99%

Monkeypox: An Unfamiliar Virus—Clinical and Epidemiological Characteristics, Diagnosis, and Treatment with Special Emphasis on Oral Health

Pandya¹,

Mehta

Miraj

et al. 2022

Diagnostics

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With the recent increased prevalence of human outbreaks, monkeypox has been recognized for decades as an infectious disease with substantial pandemic potential. The majority of cases of this virus have been observed in the European region (11,865), with few cases in the Western Pacific (54). Various governing health agencies are striving to restrain the fatal monkeypox virus (MPXV). Health practitioners around the world are learning about the many clinical manifestations of this infection, and its potential therapies. Despite the plethora of new evidence and rising cases, the essential questions remain unsolved. Thus, in this review, we have modernized the outlook for monkeypox, which will be helpful for various medical practitioners. In the light of continuing outbreaks around the world, we have also presented our assessment of the readiness of India against this outbreak, with a special focus on its effects on oral health.

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“…O MPXV penetra no organismo a partir do trato respiratório, pele lesada ou membrana mucosa, como também pelos olhos, narinas e boca (Kumar et al, 2022;Thakur et al, 2022). A transmissão zoonótica, isto é, do animal para o humano, nas áreas endêmicas, ocorre por meio da interação direta do homem com animais infectados, seja por meio de mordidas, contato com sangue, carne, fluídos corporais, lesões cutâneas ou lesões em mucosas (Guarner et al, 2022).…”

Section: Transmissãounclassified

“…Após um período inicial de viremia, o vírus se dissemina para outros órgãos. Este estágio representa o período de incubação do vírus, durando entre sete e 14 dias, com limite de 21 dias (Kumar et al, 2022;Thakur et al, 2022).…”

Section: Fisiopatologiaunclassified

“…Para os indivíduos expostos ao vírus, a temperatura corporal e os sintomas devem ser monitorados duas vezes por dia durante 21 dias, visto que este período é o tempo máximo de incubação do MPXV. Pessoas com doenças severas, pacientes imunocomprometidos, mulheres grávidas e crianças menores de oito anos devem receber tratamento antiviral (Guarner et al, 2022) (Gong et al, 2022;Guarner et al, 2022;Thakur et al, 2022;Yang et al, 2005).…”

Section: Tratamentounclassified

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Monkeypox: Uma zoonose de preocupação mundial

Lisboa¹,

Tukasan²,

Repik³

et al. 2022

Pubvet

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A monkeypox é uma doença zoonótica de origem africana, causada pelo vírus monkeypox (MPXV), pertencente à família Poxviridae. Inicialmente descoberto na década de 1958, o surto registrado em 2022 compreende a doença em sua maior distribuição mundial desde então. O vírus adentra o organismo a partir do trato respiratório e sua transmissão pode ocorrer por meio do contato direto com animais ou com hospedeiros humanos infectados. Este artigo elucida o histórico do MPXV sobre o ponto de vista epidemiológico, contemplando a origem do agente etiológico, seus mecanismos de transmissão, fisiopatologia, sintomatologia, ferramentas de diagnóstico, tratamento, meios de controle e prevenção, bem como a cronologia dos casos notificados de MPXV até o momento dessa epidemia.

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Monkeypox virus (MPX) in humans a concern: Trespassing the global boundaries – Correspondence

Cited by 19 publications

References 4 publications

Monkeypox: epidemiology, pathogenesis, treatment and prevention

Monkeypox: epidemiology, pathogenesis, treatment and prevention

Monkeypox: An Unfamiliar Virus—Clinical and Epidemiological Characteristics, Diagnosis, and Treatment with Special Emphasis on Oral Health

Monkeypox: Uma zoonose de preocupação mundial

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