Monkeypox lesions affecting the nose: A therapeutical challenge

Escudero-Tornero, Rafael; Sobral-Costas, Tristán Gabriel; Moraes‐Souza, R. De

doi:10.1111/jdv.18540

Cited by 6 publications

(10 citation statements)

References 4 publications

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“…The majority of cases of mpox infection reasonably concluded by review authors to have resulted from a single transmission route occurred through direct physical sexual contact (13, 14, 18, 20, 22, 23, 25, 26, 27, 33, 34, 36, 37, 39, 40, 42, 44, 45, 47, 48, 51, 58, 59, 60, 61, 63, 64, 65, 67, 68, 71, 72, 78, 79, 83, 85, 86, 87, 88, 92, 93, 96, 97, 103, 104, 105, 106, 107, 109, 110, 111, 112, 114, 115, 119, 126) (Table 4). Where they could identify a single route of human-to-human transmission resulting in mpox infection, investigators reported no cases in which inhalation could reasonably have been the singular mode of mpox virus transmission (Table 4).…”

Section: Number Of Incident Cases By Route Of Transmissionmentioning

confidence: 98%

“…114 studies reported cases of human-to-human mpox as a result of transmission (13–126). 39 studies were conducted prior to the 2022 outbreak (15, 16, 19, 21, 24, 31, 32, 35, 38, 43, 46, 49, 50, 53, 54, 55, 56, 62, 66, 69, 73, 74, 76, 77, 80, 81, 82, 83, 95, 99, 100, 101, 102, 116, 117, 120, 123, 124, 125) and 75 studies were published during 2022 (13, 14, 17, 18, 20, 22, 23, 25, 26, 27, 28, 29, 30, 33, 34, 36, 37, 39, 40, 41, 42, 44, 45, 47, 48, 51, 52, 57, 58, 59, 60, 61, 63, 64, 65, 67, 68, 70, 71, 72, 75, 78, 79, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, <...…”

Section: Included Studiesmentioning

confidence: 99%

“…The region of acquisition of infection was reported as follows: 37 studies from Africa (15, 19, 21, 24, 31, 32, 35, 38, 43, 49, 50, 53, 54, 55, 56, 62, 66, 69, 73, 74, 76, 77, 80, 81, 82, 83, 90, 95, 99, 100, 101, 102, 116, 120, 123, 124, 125), 1 study from the Eastern Mediterranean Region (121), 48 studies from Europe (13, 14, 18, 20, 22, 23, 25, 26, 27, 28, 29, 33, 36, 37, 39, 40, 42, 44, 45, 47, 48, 51, 52, 57, 58, 60, 61, 67, 72, 78, 79, 84, 86, 88, 89, 92, 94, 97, 98, 104, 109, 111, 112, 113, 114, 115, 122, 126), 8 studies from North America (17,46, 64, 70, 85, 93, 106, 107), and 3 ...…”

Section: Included Studiesmentioning

confidence: 99%

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Infection prevention and control measures to reduce the transmission of mpox: a systematic review

Kuehn

Fox

Guyatt

et al. 2023

Preprint

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Objectives: To assess the effectiveness of respiratory interventions and case isolation measures in reducing or preventing the transmission of mpox in humans and to inform future focused reviews on mpox transmission. Methods: The WHO Clinical Management and Infection Prevention and Control guideline 2022 development group developed three structured research questions concerning respiratory and isolation infection prevention control measures for mpox. We conducted a systematic review that included a broad search of five electronic databases. In a two-stage process, we initially sought only randomized controlled trials and observational comparative studies; when the search failed to yield eligible studies, the subsequent search included all study designs including clinical and environmental sampling studies. Results: To inform the questions the review team synthesized route of transmission data in mpox. There were 2420/3924 (61.7%) cases in which investigators identified transmission occurring through direct physical sexual contact. There proved to be no reported mpox cases in which investigators identified inhalation as a single route of transmission. There were 2/3924 (0.05%) cases in which investigators identified fomite as a single route of transmission. Clinical and environmental sampling studies generally failed to isolate mpox virus in saliva, oropharangeal swabs, mpox skin lesions, and hospital room air. Conclusions: Current findings provide compelling evidence that transmission of mpox occurs through direct physical contact. Because investigators have not reported any cases of transmission via inhalation alone the impact of respiratory infection prevention control measures in reducing transmission will be minimal. Avoiding physical contact with others, covering mpox lesions and wearing a medical mask is likely to reduce onward mpox transmission; there may be minimal reduction in transmission from additionally physically isolating patients.

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Section: Number Of Incident Cases By Route Of Transmissionmentioning

confidence: 98%

Section: Included Studiesmentioning

confidence: 99%

Section: Included Studiesmentioning

confidence: 99%

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Infection prevention and control measures to reduce the transmission of mpox: a systematic review

Kuehn

Fox

Guyatt

et al. 2023

Preprint

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“…After 5 days, there was improvement both aesthetically and symptomatically with cessation of pain. 44 …”

Section: Potential For Cidofovir Use In Severe Hmpxv Infectionmentioning

confidence: 99%

Use of cidofovir in a patient with severe mpox and uncontrolled HIV infection

Stafford

Rimmer

Gilchrist

et al. 2023

The Lancet Infectious Diseases

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“…8) Additionally, a recent report indicates that nasal lesions were the predominant presentation for monkeypox cases. 9) If the ENT doctor does not recognize for the potential unusual presentation, the monkeypox can go undetected. The nose wound may be the origin of epistaxis.…”

mentioning

confidence: 99%