Monkeypox: another pandemic in the making?

Sohal, P.S.; Gupta, Aakanksha; Gupta, Shefali; Gupta, Vasu; Jain, Ritu; Jain, Rohit

doi:10.1080/08998280.2023.2188542

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…Smallpox had been with humans for centuries [ 27 , 28 ], killing hundreds of millions of people before being declared eradicated by the World Health Organization (WHO) in the late 20th century [ 29 , 30 , 31 ]. Unfortunately, mpox resurfaced just as COVID-19 was in decline, and the virus was declared a public health emergency of international concern by the WHO in 2022 [ 32 , 33 , 34 ], suggesting that a new poxvirus epidemic may be underway. The continued occurrence of these public health events raises concerns about the spread of the virus and requires researchers to deepen their understanding of virology.…”

Section: Discussionmentioning

confidence: 99%

Lumpy Skin Disease Virus Infection Activates Autophagy and Endoplasmic Reticulum Stress-Related Cell Apoptosis in Primary Bovine Embryonic Fibroblast Cells

Tan

Liu

et al. 2023

Microorganisms

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Poxviruses have been associated with humans for centuries. From smallpox to mpox to lumpy skin disease virus (LSDV), members of the poxvirus family have continued to threaten the lives of humans and domestic animals. A complete understanding of poxvirus-mediated cellular processes will aid in the response to challenges from the viruses. In this study, we demonstrate that LSDV infection results in an abnormal ultrastructure of the endoplasmic reticulum (ER) lumen in primary bovine embryonic fibroblast (BEF) cells, and we further show that an ER imbalance occurs in LSDV-infected BEF cells. Additionally, we believe that ER stress-related apoptosis plays a role in the late apoptosis of BEF cells infected with LSDV, primarily through the activation of the CCAAT/enhancer binding protein homologous protein (CHOP)-Caspase-12 signal. In addition to cell apoptosis, a further investigation showed that LSDV could also activate autophagy in BEF cells, providing additional insight into the exact causes of LSDV-induced BEF cell death. Our findings suggest that LSDV-induced BEF cell apoptosis and autophagy may provide new avenues for laboratory diagnosis of lumpy skin disease progression and exploration of BEF cell processes.

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Section: Discussionmentioning

confidence: 99%

Lumpy Skin Disease Virus Infection Activates Autophagy and Endoplasmic Reticulum Stress-Related Cell Apoptosis in Primary Bovine Embryonic Fibroblast Cells

Tan

Liu

et al. 2023

Microorganisms

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“…It will be vital to stop the spread of this disease using alternatives such as vaccinia immune globulins, herbal traditional remedies, and novel discoveries. Globally research organizations and the pharmaceutical industry should devote greater resources to the study of novel antiviral agents that target various viral life cycles [ 36 ]. Live, replication-incompetent vaccinia virus and Live, replication-competent vaccinia virus are the two vaccines that are now available.…”

Section: Reviewmentioning

confidence: 99%

Recent Outbreak of Monkeypox: Implications for Public Health Recommendations and Crisis Management in India

Kumar,

Borkar,

Choudhari

et al. 2023

Cureus

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Monkeypox is a rare and self-limiting disease that was eradicated globally through vaccination approximately forty years ago, following the eradication of smallpox. The purpose of this article is to explore the implications of the recent monkeypox outbreak on public health recommendations and crisis management in India. An overview of the consequences of the current monkeypox epidemic on public health, epidemiology, clinical findings, management, challenges, and existing strategies for this disease, along with recommendations are discussed. It is crucial to develop evidence-based recommendations for the diagnosis and treatment of monkeypox, as well as early case identification and contact tracing. To prevent the spread of infection, travelers from affected countries should be subjected to health testing and quarantine. In order to successfully control the outbreak, a multidisciplinary team should be established to manage the monkeypox virus at tertiary care facilities, and health workers with occupational exposure to the virus should be assessed and given management plans.

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Monkeypox: another pandemic in the making?

Cited by 2 publications

References 39 publications

Lumpy Skin Disease Virus Infection Activates Autophagy and Endoplasmic Reticulum Stress-Related Cell Apoptosis in Primary Bovine Embryonic Fibroblast Cells

Lumpy Skin Disease Virus Infection Activates Autophagy and Endoplasmic Reticulum Stress-Related Cell Apoptosis in Primary Bovine Embryonic Fibroblast Cells

Recent Outbreak of Monkeypox: Implications for Public Health Recommendations and Crisis Management in India

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