Monitoring the Spread of HIV and AIDS in Scotland 1983 – 1994

Goldberg, David J.; Davis, Barbara; Allardice, G.; McMenamin, Jim; Codere, G

doi:10.1177/003693309604100501

Cited by 22 publications

(12 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following this step, data for 97,250 individuals who had been tested at least once for HCV between 1993 and 2007 were available. Extra data on risk activities were obtained via deterministic record-linkage to the national HIV test database also held by HPS (Goldberg, Davis, Allardice, McMenamin, & Codere, 1996). This database contained records for 415,555 HIV tests conducted over the period 1988-2007, among which 36,618 mention IDU as risk activity.…”

Section: Study Population and Data Sourcesmentioning

confidence: 99%

Examination of the risk of reinfection with hepatitis C among injecting drug users who have been tested in Glasgow

McDonald

Hutchinson

Cameron

et al. 2012

International Journal of Drug Policy

View full text Add to dashboard Cite

a b s t r a c tBackground: Unsafe injecting practices put injecting drug users (IDUs) at repeat exposure to infection with the hepatitis C virus (HCV). It has not yet been determined if spontaneously clearing one's primary infection influences the risk of reinfection; our aim was to estimate the relative risk of reinfection in IDUs who have cleared the virus. Methods: We conducted a retrospective study using a large database of HCV test results covering Greater Glasgow Health Board during 1993-2007 to calculate rates of infection and reinfection in current/former IDUs. The relative risk of (re)infection in previously infected compared with never-infected IDUs was estimated using Poisson regression, adjusting for age at study entry, sex, and calendar period of test. Results: Although the rate of reinfection in IDUs who were HCV antibody-positive, RNA-negative at baseline was lower (7/100 person-years, 95% CI: 5-9) than the rate of acute infection in IDUs who were HCV antibody-negative at baseline (10/100 person-years, 95% CI: 9-12), the risk of reinfection was not significantly different than the risk of initial infection (adjusted rate ratio = 0.78, 95% CI: 0.57-1.08). Conclusion: We found only weak evidence for a reduced risk of HCV reinfection in IDUs who had cleared their previous infection. Further research among those who have cleared infection through antiviral therapy is needed to help inform decisions regarding treatment of IDUs.

show abstract

Section: Study Population and Data Sourcesmentioning

confidence: 99%

Examination of the risk of reinfection with hepatitis C among injecting drug users who have been tested in Glasgow

McDonald

Hutchinson

Cameron

et al. 2012

International Journal of Drug Policy

View full text Add to dashboard Cite

show abstract

“…Health Protection Scotland maintains a database of all HIV tests conducted within Scotland,4 excluding routine screening (eg, antenatal, renal, travel/insurance; the database was developed to assess prevalence among those individuals actively seeking or who had been offered, a diagnostic HIV test) and testing of previously known HIV positives and persons under 15 years of age. Data are provided by all National Health Service laboratories in Scotland that perform HIV testing.…”

Section: Methodsmentioning

confidence: 99%

“…Harm reduction services in Glasgow and elsewhere in Scotland were expanded during the 1990s, and a decrease in HIV prevalence among Glasgow's injectors from 4.8% in 1987 to 1.0% in 1992 has been reported,3 suggesting that these measures helped to reduce the spread of HIV in this population 4…”

Section: Introductionmentioning

confidence: 99%

Trends in the incidence of HIV in Scotland, 1988–2009

et al. 2011

View full text Add to dashboard Cite

show abstract

“…In Scotland, the HIV epidemic had been characterised by large numbers of male and female injecting drug users in Edinburgh and Dundee becoming HIV infected during the early to mid-1980s, 4 and prevalence rates of 51% 5 and 39%, 6 respectively, had been recorded in each city. By 1990, there was evidence of increasing numbers of infections in non-injecting heterosexuals who had had injecting sexual partners, and thus HIV appeared to be spreading into the more general population.…”

mentioning

confidence: 99%

“…To determine whether HIV was seeding into the lower risk male heterosexual population in particular, it was decided to perform unlinked anonymous HIV testing of specimens from hospital patients and general practice attenders. The study would be piloted in Glasgow, which had experienced less HIV spread than that seen in the east of Scotland, 4 and if successful would be extended to other centres.…”

mentioning

confidence: 99%

Unlinked anonymous HIV study of hospital patients and general practice attenders in Glasgow, 1991-1997

Johnston

2000

Journal of Clinical Pathology

View full text Add to dashboard Cite

Aim-To determine whether HIV is spreading from injecting drug users and homosexual/bisexual males into lower risk heterosexual populations in Glasgow, Scotland, and to pilot a method of monitoring HIV prevalence which involves testing routine biochemistry specimens. Methods-An unlinked anonymous HIV testing study of hospital patients and general practice attenders was conducted during January 1992 to December 1997. Testing was performed on routine biochemistry specimens from patients aged 16-49 years attending two hospitals with catchment areas covering the north and the east of the city. Results-78 260 specimens were tested in the study period and no patient objected to their samples being tested anonymously. HIV prevalence rates among male and female subjects were 0.63% and 0.01%, respectively; the large diVerence in prevalence resulted, in part, from the inclusion of HIV infected haemophiliac patients who attended one of the hospitals. Prevalence among male general practice patients ranged between 0.1% and 0.2%, while that for male patients attending surgical or surgically related specialties was 0.1%. Conclusions-The prevalence data indicate that HIV has not seeded from the high risk groups into the wider heterosexual population, and that the risk of a surgeon acquiring HIV occupationally is extremely low in a city which has an HIV prevalence similar to or greater than that seen in most other parts of the United Kingdom. Large numbers of residual specimens from busy biochemistry laboratories can be processed for unlinked anonymous testing without interfering with the laboratories' routine functions. This survey approach might be best suited to monitoring HIV trends in developing countries with relatively high prevalence rates and where transmission is principally heterosexual. (J Clin Pathol 2000;53:117-121)

show abstract

Monitoring the Spread of HIV and AIDS in Scotland 1983 – 1994

Cited by 22 publications

References 34 publications

Examination of the risk of reinfection with hepatitis C among injecting drug users who have been tested in Glasgow

Examination of the risk of reinfection with hepatitis C among injecting drug users who have been tested in Glasgow

Trends in the incidence of HIV in Scotland, 1988–2009

Unlinked anonymous HIV study of hospital patients and general practice attenders in Glasgow, 1991-1997

Contact Info

Product

Resources

About