Monitoring the functionalization of single-walled carbon nanotubes with chitosan and folic acid by two-dimensional diffusion-ordered NMR spectroscopy

Abstract

Monitoring the functionalization of single-walled carbon nanotubes with chitosan and folic acid by two-dimensional diffusion-ordered nmr spectroscopy, Carbon (2012), doi: 10.1016/j.carbon. 2012.02.010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Monitoring the functionalization of single-walled carbon nanotubes with chitosan and folic acid by two-dimensional diffusion-ordered nmr spectroscopy ABSTRACTA conjugate between single-walled carbon nanotubes, chitosan and folic acid has been prepared. It was characterized by diffusion ordered two-dimensional hydrogen-1 nuclear magnetic resonance and hydrogen-1 nuclear magnetic resonance spectroscopy which revealed the presence of a conjugate that was generated by the linkage between the carboxyl moiety of the folic acid and the amino group of the chitosan, which in turn was non-covalently bound to the single-walled carbon nanotubes. The obtained diffusion coefficient values demonstrated that free folic acid diffused more rapidly than the folic acid conjugated to single-walled carbon nanotubes-chitosan. The values of the proton signal of hydrogen-1 nuclear magnetic resonance spectroscopy and two-dimensional hydrogen-1 nuclear magnetic resonance spectroscopy further confirmed that the folic acid was conjugated to the chitosan, wrapping the single-walled carbon nanotubes.

A novel DAD type and folic acid conjugated fluorescent monomer as a targeting probe for imaging of folate receptor overexpressed cells

“…Moreover, the peaks between 1.44 and 1.29 correspond to the protons of the alkyl chain, which plays the role of bridging between BEDOA‐6 and FA. These results reveal successful conjugation of FA to BEDOA‐6, and are consistent with previous studies …”

Non-covalent conjugates of single-walled carbon nanotubes and folic acid for interaction with cells over-expressing folate receptors

“…17 Hence, the UV/Vis data indicate no structural changes of the SWCNTs and FA that could be related to the SWCNT-FA modication.…”

Preparation of carboxymethyl cellulose based microgels for cell encapsulation

“…The signals at 1.79~2.02 ppm (2a), 0.96~1.19 ppm (2b) and 2.75 ppm (2c) were ascribed to the byproduct being formed between CMC and EDC (CMC-EDC). EDC and phenolic groups of 4-hydroxybenzylamine reacted to form CMC-g-Ph-EDC, resulting in a change in proton shift of the aromatic protons at 7.51 and 7.35 ppm (3a and 3b) [29].…”