Monitoring the distribution of prompt gamma rays in boron neutron capture therapy using a multiple-scattering Compton camera: A Monte Carlo simulation study

Lee, Taewoong; Lee, Hyounggun; Lee, Wonho

doi:10.1016/j.nima.2015.07.038

Cited by 17 publications

(4 citation statements)

References 22 publications

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“…To compare the level of signal from the BUR and background noise, the contrast and signal-to-noise ratio (SNR) were acquired for the region of interest (ROI) for each BURs and for the background. The contrast and SNR can be calculated using the following equations: [ 21 , 22 ]

where S is the average signal in the BUR, B is the average background signal, and B SD is the standard deviation of the background. The size of the ROI was the original physical diameter of the center of the BURs based on the MCNPX input source code.…”

Section: Methodsmentioning

confidence: 99%

Quantitative analysis of prompt gamma ray imaging during proton boron fusion therapy according to boron concentration

Shin

Kim

et al. 2017

Oncotarget

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The purpose of this study is to evaluate the prompt gamma ray imaging technique according to the clinical boron concentration range during proton boron fusion therapy (PBFT). To acquire a prompt gamma ray image from 32 projections, we simulated four head single photon emission computed tomography and a proton beam nozzle using a Monte Carlo simulation. We used modified ordered subset expectation maximization reconstruction algorithm with a graphic processing unit for fast image acquisition. Boron concentration was set as 20 to 100 μg at intervals of 20 μg. For quantitative analysis of the prompt gamma ray image, we acquired an image profile drawn through two boron uptake regions (BURs) and calculated the contrast value, signal-to-noise ratio (SNR), and difference between the physical target volume and volume of the prompt gamma ray image. The relative counts of prompt gamma rays were noticeably increased with increasing boron concentration. Although the intensities on the image profiles showed a similar tendency according to the boron concentration, the SNR and contrast value were improved with increasing boron concentration. This study suggests that a tumor monitoring technique using prompt gamma ray detection can be clinically applicable even if the boron concentration is relatively low.

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Section: Methodsmentioning

confidence: 99%

Quantitative analysis of prompt gamma ray imaging during proton boron fusion therapy according to boron concentration

Shin

Kim

et al. 2017

Oncotarget

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“…A Compton camera provides an alternative method for prompt gamma imaging during BNCT and does not require the use of any physical collimators. There has been some previous research on the feasibility of using a Compton camera for prompt gamma imaging during BNCT [16][17][18], but it has been less explored than the SPECT systems mentioned previously. An overview of research into the use of Compton cameras for BNCT is presented in [19].…”

Section: Introductionmentioning

confidence: 99%

A feasibility study using an array of LaBr3(Ce) scintillation detectors as a Compton camera for prompt gamma imaging during BNCT

Nutter,

Price,

Kokalova

et al. 2024

Front. Phys.

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Boron Neutron Capture Therapy (BNCT) is a binary cancer therapy where a low energy neutron beam is incident upon a patient who has been administered a tumour-seeking 10B loaded compound. The neutron capture reaction on 10B results in the production of two short range particles, 7Li and 4He, that deposit all of their energies within the targeted cell. However, accurate, online dosimetry during BNCT is challenging as it requires knowledge of both the neutron fluence and 10B concentration in cells. An additional product in the neutron capture reaction on 10B is a 478 keV prompt gamma ray, and if the production vertices of these gamma rays could be imaged by an external camera, the density of the vertices could be used to infer the dose delivered to the patient. In this study, the feasibility of using an array of LaBr3 scintillators as a modified Compton camera for prompt gamma imaging during BNCT was investigated using Geant4 simulations. These simulations demonstrated that a phantom containing a 3 cm diameter region of 400 ppm 10B could be reconstructed using clinically relevant neutron fluences. This result opens up more possibilities for future research to improve dosimetry during BNCT.

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“…Therefore, a possible protocol based on the measurement of the prompt gammaray of 478 keV becomes significant to be able to reconstruct in vivo the spatial distribution of the dose in the area of interest. To such an aim, we will investigate imaging algorithm methods such as computed tomography using "Compton camera techniques" [3].…”

Section: Introductionmentioning

confidence: 99%

Study of Alternative Imaging Methods for In Vivo Boron Neutron Capture Therapy

Ramos López,

Pugliese,

Iaselli

et al. 2023

Cancers

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Boron Neutron Capture Therapy (BNCT) is an innovative and highly selective treatment against cancer. Nowadays, in vivo boron dosimetry is an important method to carry out such therapy in clinical environments. In this work, different imaging methods were tested for dosimetry and tumor monitoring in BNCT based on a Compton camera detector. A dedicated dataset was generated through Monte Carlo tools to study the imaging capabilities. We first applied the Maximum Likelihood Expectation Maximization (MLEM) iterative method to study dosimetry tomography. As well, two methods based on morphological filtering and deep learning techniques with Convolutional Neural Networks (CNN), respectively, were studied for tumor monitoring. Furthermore, clinical aspects such as the dependence on the boron concentration ratio in image reconstruction and the stretching effect along the detector position axis were analyzed. A simulated spherical gamma source was studied in several conditions (different detector distances and boron concentration ratios) using MLEM. This approach proved the possibility of monitoring the boron dose. Tumor monitoring using the CNN method shows promising results that could be enhanced by increasing the training dataset.

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Monitoring the distribution of prompt gamma rays in boron neutron capture therapy using a multiple-scattering Compton camera: A Monte Carlo simulation study

Cited by 17 publications

References 22 publications

Quantitative analysis of prompt gamma ray imaging during proton boron fusion therapy according to boron concentration

Quantitative analysis of prompt gamma ray imaging during proton boron fusion therapy according to boron concentration

A feasibility study using an array of LaBr3(Ce) scintillation detectors as a Compton camera for prompt gamma imaging during BNCT

Study of Alternative Imaging Methods for In Vivo Boron Neutron Capture Therapy

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