Monitoring the developmental impact of copper and silver nanoparticle exposure in Drosophila and their microbiomes

Xu, Han; Geller, Brennen; Moniz, Kristy; Das, Pranab Jyoti; Chippindale, Adam K.; Walker, Virginia K.

doi:10.1016/j.scitotenv.2013.12.129

Cited by 90 publications

(55 citation statements)

References 44 publications

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“…(Mueller and Barter, 2015; Perkhulyn et al, 2015; Weiner et al, 2014). It is also possible that the gut microbiota is being affected (Broderick and Lemaitre, 2012; Han et al, 2014). The gut microbiota affects many aspects of physiology including digestion, immune function, growth, metabolism (Broderick and Lemaitre, 2012) and mating preference (Sharon et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Atrazine exposure affects longevity, development time and body size in Drosophila melanogaster

Marcus

Fiumera

2016

Journal of Insect Physiology

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Atrazine is the one of the most widely used herbicides in the United States and non-target organisms may encounter it in the environment. Atrazine is known to affect male reproduction in both vertebrates and invertebrates but less is known about its effects on other fitness traits. Here we assessed the effects of five different chronic exposure levels on a variety of fitness traits in Drosophila melanogaster. We measured male and female longevity, development time, proportion pupated, proportion emerged, body size, female mating rate, fertility and fecundity. Atrazine exposure decreased the proportion pupated, the proportion emerged and adult survival. Development time was also affected by atrazine and exposed flies pupated and emerged earlier than controls. Although development time was accelerated, body size was actually larger in some of the exposures. Atrazine exposure had no effect on female mating rate and the effects on female fertility and fecundity were only observed in one of the two independent experimental blocks. Many of the traits showed non-monotonic dose response curves, where the intermediate concentrations showed the largest effects. Overall this study shows that atrazine influences a variety of life history traits in the model genetic system, D. melanogaster, and future studies should aim to identify the molecular mechanisms of toxicity.

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Section: Discussionmentioning

confidence: 99%

Atrazine exposure affects longevity, development time and body size in Drosophila melanogaster

Marcus

Fiumera

2016

Journal of Insect Physiology

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“…395 It was observed that copper and silver nanoparticle(AgNPs) may reduce adult longevity in Drosophila and decreased sperm competition. 396 The effects of AgNPs in rainbow trout (Oncorhynchus mykiss) hepatocytes were explored. 397 This study proposed that AgNPs could influence hormone-regulated cell signaling pathways.On the exposure of Ag or Al 2 O 3, nanoparticles cyotoxic effects were observed in soil bacteria viz.…”

Section: Toxicity Of Silver Nanoparticlesmentioning

confidence: 99%

Critical Review on the Toxicity of Some Widely Used Engineered Nanoparticles

Srivastava

Gusain

Sharma

2015

Ind. Eng. Chem. Res.

238

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With tremendous increase in development of nanotechnology, there is a developing enthusiasm towards the application of nanoparticles in diverse areas. Carbon nanotubes, fullerenes, quantum dots, dendrimers, iron oxide, silica, gold and silver nanoparticles are frequently used in different applications such as drug delivery, as ceramic materials, semiconductors, electronics, in medicine, cosmetics, etc. Some of these nanoparticles have shown major toxic effects on fauna, flora and human beings like inflammation, cytotoxicity, tissue ulceration and reduction of cell viability. SWCNT and MWCNT can induce oxidative stress and fibrosis in the lungs of rat and mice. SWCNTs can also induce oxidative stress to the nervous system in human beings. Inflammatory injury and respiratory distress can be observed due to TiO 2 nanoparticles with small diameter. Nanoparticles can also pose detrimental effects on plants such as decreased growth rate, genomic and proteomic changes, etc. Toxicity of nanoparticles arises because of their specific characteristics such as greater 'surface area to volume ratio' compared with bulk particles of the same chemistry. The objective of this review is to critically evaluate the current literature on the toxicity of nanoparticles.

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“…To control for silver ions, powders of silver microparticles (7.5 µm; AgMPs) were purchased from MK Nano (MK Impex Canada, Mississauga, Canada). Suspension of these non-functionalized AgMPs were also characterized by TEM as reported elsewhere [7].…”

Section: Silver Nanoparticle and Microparticle Characterizationmentioning

confidence: 99%

“…Surface charges associated with some AgNPs preparations may contribute to their toxicity [4]. However, multiple studies have highlighted the critical role of nano-size dependent effects compared to ionic silver, with an emphasis on the unique properties of AgNPs [5][6][7]. Although there are reports of mammalian cell cytotoxicity [8][9][10], these effects are likely relatively minimal at the concentrations used for antimicrobial activity [11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interaction between a Broad-spectrum Antibiotic and Silver Nanoparticles in a Human Gut Ecosystem

Das¹,

Saulnier²,

Carlucci³

et al. 2016

J Nanomed Nanotechnol

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The antimicrobial properties of engineered silver nanoparticles (AgNPs) have led to their wide use in diverse consumer products. Ampicillin too, acts as a broad-spectrum antibiotic and thus is prescribed for the treatment of many common infections, but with the problematic emergence of ampicillin-resistant bacteria. As a consequence, there has been some interest in the combination of these two distinct chemistries prompted by the clinical challenge of resistance. Prior to trials of combination therapy, however, it is important to understand the impact on human microbiomes. Here we investigated the effect of ampicillin and AgNPs, both individually and in a combined therapy on a human intestinal ecosystem known as a defined experimental community (DEC-60). The DEC-60 consortia was co-treated with a concentration of AgNPs (50 mg/L) known to have a minimal impact, and a broad range of the antibiotic up to the clinical dose (6 mg/L). The addition of AgNPs to sub-clinical doses of ampicillin (0.06 and 0.6 mg/L) had a significantly impact (p<0.001-0.05) on gas production (%CO 2 and %N 2 ) and changed the composition of fatty acid methyl ester signatures so that they were distinct from each individual antimicrobial, as well as un-treated control cultures. DNA sequencing, supported by multidimensional scaling analysis, confirmed the community shift and showed distinct phylogenetic distributions at different concentrations of ampicillin, depending on the presence of AgNPs. Together, these results suggest that the antibacterial efficacy of sub-clinical doses of ampicillin was increased by AgNPs, possibly due to the synergistic effect of damage to the bacterial cell walls. Not only does this analysis provide insight into AgNP toxicity, it offers some promise that combined antimicrobial therapies may have value in a clinical setting.

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Monitoring the developmental impact of copper and silver nanoparticle exposure in Drosophila and their microbiomes

Cited by 90 publications

References 44 publications

Atrazine exposure affects longevity, development time and body size in Drosophila melanogaster

Atrazine exposure affects longevity, development time and body size in Drosophila melanogaster

Critical Review on the Toxicity of Some Widely Used Engineered Nanoparticles

Interaction between a Broad-spectrum Antibiotic and Silver Nanoparticles in a Human Gut Ecosystem

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