Monitoring the activities of Italian colposcopy clinics before and during the COVID-19 pandemic

Carpini, Giovanni Delli; Rossi, Paolo Giorgi; Giannella, Luca; Giuseppe, Jacopo Di; Clemente, Nicolò; Sopracordevole, Francesco; Barbero, Maggiorino; Bogani, Giorgio; Vincenzo, Rosa De; Origoni, Massimo; Cantatore, Francesco; Gardella, Barbara; Dominoni, Mattia; Monti, Ermelinda; Liverani, Carlo Antonio; Viscardi, Anna; Pagan, Alessio; Amadori, Andrea; Alessi, Chiara; Andolfatto, Matteo; Cattani, Paolo; Pieralli, Annalisa; Stevenazzi, Guido; Ciavattini, Andrea

doi:10.3802/jgo.2023.34.e7

Cited by 4 publications

(6 citation statements)

References 11 publications

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“…The increase in numbers during the pandemic is in contrast to many other published findings. There have been many reports stating that the number of women seen for cervical cancer screening dropped significantly during the first month of the pandemic (19,21,22,31). Except for the first 4 weeks of the pandemic, scheduling in our certified dysplasia unit remained unaffected by the pandemic.…”

Section: Discussionmentioning

confidence: 91%

“…In many other countries, cervical cancer screening was interrupted by the pandemic. In Italy, the number of patients receiving spontaneous screening declined by 14% and use of the CO2 laser technique fell by 30% in the period March 1, 2020 to February 28, 2021 in comparison with March 1, 2019 to February 29, 2020 (31). In a Canadian study in Ontario, the reduction in cervical cancer screening was 51% in the first 6 months of the pandemic, but started to recover by August 2020, almost reaching prepandemic levels based on historical data (19).…”

Section: Discussionmentioning

confidence: 99%

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Impact of the Corona Pandemic on Cervical Cancer Screening Assessment

STUEBS,

BEHRENS,

SEIBOLD

et al. 2024

In Vivo

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Background/Aim: The global impact of the COVID-19 pandemic resulted in disruptions to healthcare systems throughout the world. The numbers of cytology examinations, human papillomavirus (HPV) tests, and women referred for colposcopy decreased in many countries. There have been no reports on cervical cancer screening in Germany. This study aimed to describe changes in the numbers of colposcopies, cytology examinations, HPV tests, and histological results during the pandemic compared to the pre-pandemic years in order to evaluate the impact of the COVID-19 pandemic on cervical cancer screening. Patients and Methods: The numbers of colposcopies, cytology examinations, HPV tests, and histologic results were analyzed retrospectively for the period January 2018 to December 2022. The 2 years period before the pandemic (2018 and 2019) were compared with the 3 years period of the pandemic (2020)(2021)(2022). Results: In total, 6,518 colposcopies were performed in 5,579 women. The numbers of colposcopies, cytology examinations, and high-risk HPV (hrHPV) tests increased during the pandemic years. The number of biopsies per year taken was stable (range=450-554). The relative numbers of cervical intraepithelial neoplasia (CIN) III/HSIL findings were stable, while the numbers of cervical cancers identified increased slightly from 15 (6.6%) in 2018 to 22 (7.4%) in 2022. Conclusion: Increases in numbers of women examined and colposcopies were observed in the years 2021 and 2022 during the pandemic, in comparison to the preceding years. These also led to increases in the figures for cytology, hrHPV, histology, and operations. The onset of the pandemic occurred in the same year as a newly organized screening program started in Germany. The increases might therefore be due to the newly organized screening system.Cervical cancer (CC) is one of the most common cancers amongst women worldwide (1-5). High-grade squamous 734

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Impact of the Corona Pandemic on Cervical Cancer Screening Assessment

STUEBS,

BEHRENS,

SEIBOLD

et al. 2024

In Vivo

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“…Since the majority of HPV-related lesions occur in the uterine cervix, hysterectomy ( per se ) protects from the risk of developing most of HPV-related lesions. 11 However, the burden of HPV-related disease is not negligible, even in this cluster of patients. 12 According to the cumulative analysis of two prospective trials (protocol 013 (FUTURE I) and protocol 015 (FUTURE II)) patients having treatment for CIN experienced a 6% risk of developing HPV-related disease in vulvar and vaginal districts.…”

Section: Introductionmentioning

confidence: 80%

HPV-related lesions after hysterectomy for high-grade cervical intraepithelial neoplasia and early-stage cervical cancer: A focus on the potential role of vaccination

Bogani,

Sopracordevole,

Ciavattini

et al. 2023

Tumori

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Objective: To date, no data supports the execution of vaccination after hysterectomy for high-grade cervical intraepithelial neoplasia (CIN2+) and early-stage cervical cancer. We aim to evaluate the potential effect of vaccination after hysterectomy for high-grade cervical intraepithelial neoplasia and early-stage cervical cancer. Methods: This is a multi-center retrospective study evaluating data of women who develop lower genital tract dysplasia (including anal, vulvar and vaginal intra-epithelial neoplasia) after having hysterectomy for CIN2+ and FIGO stage IA1- IB1 cervical cancer. Results: Overall, charts for 77 patients who developed lower genital tract dysplasia were collected. The study population included 62 (80.5%) and 15 (19.5%) patients with CIN2+ and early-stage cervical cancer, respectively. The median (range) time between hysterectomy and diagnosis of develop lower genital tract dysplasia was 38 (range, 14-62) months. HPV types covered by the nonavalent HPV vaccination would potentially cover 94.8% of the development of lower genital tract dysplasia. Restricting the analysis to the 18 patients with available HPV data at the time of hysterectomy, the beneficial effect of nonvalent vaccination was 89%. However, considering that patients with persistent HPV types (with the same HPV types at the time of hysterectomy and who developed lower genital tract dysplasia) would not benefit from vaccination, we estimated the potential protective effect of vaccination to be 67% (12 out of 18 patients; four patients had a persistent infection for the same HPV type(s)). Conclusions: Our retrospective analysis supported the adoption of HPV vaccination in patients having treatment for HPV-related disease. Even in the absence of the uterine cervix, HPV vaccination would protect against develop lower genital tract dysplasia. Further prospective studies have to confirm our preliminary research.

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“…Globally, the COVID-19 outbreak has impacted negatively the utilization of preventative healthcare 45. In Italy, the first phase of the COVID-19 outbreak had an impact on the primary and secondary prevention of HPV 46. On December 31, 2019, HPV vaccination coverage ranged from 41.6% to 70.4% for women aged 12–23 years and the Italian cervical cancer screening coverage was 79.9% (48.7% organized screening and 30.8% spontaneous screening) in the period 2016–2019 46.…”

Section: Hpv Vaccination In Italymentioning

confidence: 99%

“…In Italy, the first phase of the COVID-19 outbreak had an impact on the primary and secondary prevention of HPV 46. On December 31, 2019, HPV vaccination coverage ranged from 41.6% to 70.4% for women aged 12–23 years and the Italian cervical cancer screening coverage was 79.9% (48.7% organized screening and 30.8% spontaneous screening) in the period 2016–2019 46. Recently, the Italian Society of Colposcopy and Cervico-Vaginal Pathology (SICPCV) suggested that during the COVID-19 outbreak the number of cervical excisional procedures (such as conization) decreased by 8.8%.…”

Section: Hpv Vaccination In Italymentioning

confidence: 99%

Human papillomavirus (HPV) vaccination: a call for action in Italy

Bogani

Ghelardi²,

Sopracordevole

et al. 2023

Int J Gynecol Cancer

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Human papillomavirus (HPV) is the most common sexually transmitted infection. The implementation of primary prevention aims to reduce the burden of HPV infection and HPV-related disease. However, HPV-related diseases are still a concern, even in high-income countries. Approximately 570 000 new cervical cancer cases are diagnosed in Italy every year. Prophylactic HPV vaccines have been developed to minimize the spread of HPV. Growing evidence supports the administration of HPV vaccines (even just one dose) in reducing the prevalence of HPV infection and HPV-related disease including cancers. HPV vaccines are characterized by a high level of efficacy (>95%) in women who are naïve to HPV; however, they do not increase clearance in patients with ongoing HPV infection. With more than 200 million doses administered to date, HPV vaccines are considered to be safe and effective at preventing HPV-related infections and cancers. In this review we aim to review the current evidence regarding HPV vaccination and to describe trends in HPV vaccination coverage in Italy. In Italy, vaccination against HPV has been included in the National Immunization Plan (NIP) since 2007–2008. Using data abstracted from the Italian Ministry of Health, we analyzed changes in HPV vaccination coverage. We observed that HPV vaccines are underutilized and coverage rates are decreasing. Looking at the target population (females and males aged 11–12 years) in Italy, a decrease in coverage rates was observed. A call for action, improved HPV awareness, and education are the key elements to enhance the widespread adoption of HPV vaccination.

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Monitoring the activities of Italian colposcopy clinics before and during the COVID-19 pandemic

Cited by 4 publications

References 11 publications

Impact of the Corona Pandemic on Cervical Cancer Screening Assessment

Impact of the Corona Pandemic on Cervical Cancer Screening Assessment

HPV-related lesions after hysterectomy for high-grade cervical intraepithelial neoplasia and early-stage cervical cancer: A focus on the potential role of vaccination

Human papillomavirus (HPV) vaccination: a call for action in Italy

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