Monitoring propranolol treatment in periocular infantile haemangioma

Burne, Rebecca; Taylor, Robert H.

doi:10.1038/eye.2014.237

Cited by 7 publications

(5 citation statements)

References 13 publications

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“…The studies that included other treatment modalities (e.g., Corticosteroids or surgery) are not included in the table. References (year) Number of patients and age at presentation (weeks/months) Tumor size (mm) Location Albanese et al (2019) 4 Six patients (median age of 2.7 weeks) Not available Deep ocular Ginguerra et al (2018) 15 Four patients (median age 15 weeks) 19 (median size) Deep ocular Lewitt et al (2014) 16 Five patients (median age of 5.8 weeks) Not available Deep ocular Thoumazet al (2012) 17 One patient (2 weeks) Not available Deep ocular Burne et al (2011) 18 Nine patients (6 patients with deep ocular localization) (8–50 weeks) Not available Deep ocular Li et al (2010) 19 One patient (4 weeks) 30 × 15 × 25 Deep ocular Fay et al (2010) 20 One patient (4 weeks) Not available Deep ocular Cheng et al (2010) 21 Ten patients (3 days–6 months) 756.7 (median size) Deep ocular …”

Section: Discussionmentioning

confidence: 99%

Isolated deep orbital hemangioma treated successfully with oral propranolol in a 2-month-old infant: Case report with literature review

Zvizdić

Bulja

Sidran

et al. 2021

American Journal of Ophthalmology Case Reports

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Purpose Infantile hemangiomas (IH) are the most common benign vascular tumors of infancy. Ocular complications due to orbital IH include strabismal, deprivational, or anisometropic astigmatism, and visual loss secondary to amblyopia. Observations We report a case of a two-month-old female infant with a severe deep orbital IH. The diagnosis was established by clinical examination and magnetic resonance imaging (MRI). The patient was treated with oral propranolol for six months. Complete tumor regression was observed clinically and by MRI following the treatment. The patient showed no adverse effects or tumor recurrence at the 14-month follow-up. Conclusions and Importance Despite its benign nature, periorbital IH requires a rapid diagnosis and prompt treatment to prevent vision loss, particularly in infants. Our case confirms that oral propranolol may be regarded as a safe drug for periorbital IH with an excellent outcome.

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Section: Discussionmentioning

confidence: 99%

Isolated deep orbital hemangioma treated successfully with oral propranolol in a 2-month-old infant: Case report with literature review

Zvizdić

Bulja

Sidran

et al. 2021

American Journal of Ophthalmology Case Reports

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“…The impressive effect of propranolol in treating infantile hemangiomas has provoked a paradigm shift in their management over the past few years [ 18 , 19 ]. In 2008, propranolol, a nonselective β-adrenergic antagonist, was serendipitously discovered to cause regression of proliferating hemangiomas in newborns receiving treatment for cardiovascular disease [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Debulking surgery for venous hemangioma arising from the epicardium: report of a case

et al. 2017

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BackgroundCardiac hemangiomas are rare benign vascular tumors that can occur in any cardiac layer: endocardium, myocardium, or epicardium. Histologically, cardiac hemangiomas may be classified as capillary, cavernous, or arteriovenous; venous hemangiomas are extremely rare.Case presentationA 46-year-old man reported experiencing precordial discomfort. Computed tomography revealed a massive tumor adjacent to the right ventricle. The right coronary artery was found to be located at the center of the tumor. Cardiovascular angiography showed that the artery was completely encased by the tumor without any obstruction and that the right ventricular lumen was compressed by the tumor. Surgical debulking of the tumor was performed under cardiopulmonary bypass, and the frozen section led to a diagnosis of benign hemangioma. The tumor was debulked as much as possible until the right coronary artery appeared. For decompression of the heart, the pericardium was left open to the thoracic cavity and unsutured. Histopathologic examination revealed a diagnosis of epicardial venous hemangioma.ConclusionsCardiac hemangioma should be included in the differential diagnosis of mediastinal tumor in reference to the location and flow of the coronary artery. Surgical resection, or at least tumor debulking, is required to confirm the diagnosis and prevent further complications and has a favorable clinical outcome.

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“…Furthermore, laser treatment, embolization, or surgery may be effective for superficial hemangiomas, but remains problematic and harmful for deep or extensive forms, such as intraorbital hemangiomas. The impressive effect of propranolol in treating infantile hemangiomas has provoked a paradigm shift in their management since 2008 3,11. In addition, good tolerance of propranolol has been established 12.…”

Section: Discussionmentioning

confidence: 99%

Excellent response of infantile orbital hemangioma to propranolol

Sendrasoa¹,

Ranaivo²,

Razanakoto³

et al. 2016

IMCRJ

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Infantile hemangiomas are the most common vascular neoplasm that present in infancy, with more than half affecting the head and neck region. Periocularly, hemangiomas may be complicated by visual loss through induction of strabismal, deprivational, or anisometropic astigmatism. We report a case of a 5-year-old girl who presented with orbital hemangioma with potential risk of visual loss who had excellent response to propranolol.

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Monitoring propranolol treatment in periocular infantile haemangioma

Cited by 7 publications

References 13 publications

Isolated deep orbital hemangioma treated successfully with oral propranolol in a 2-month-old infant: Case report with literature review

Isolated deep orbital hemangioma treated successfully with oral propranolol in a 2-month-old infant: Case report with literature review

Debulking surgery for venous hemangioma arising from the epicardium: report of a case

Excellent response of infantile orbital hemangioma to propranolol

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